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Aggressive organ penetration and high vector transmissibility of epidemic dengue virus-2 Cosmopolitan genotype in a transmission mouse model
Dengue virus (DENV) causes dengue fever and severe hemorrhagic fever in humans and is primarily transmitted by Aedes aegypti and A. albopictus mosquitoes. The incidence of DENV infection has been gradually increasing in recent years due to global urbanization and international travel. Understanding...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8034735/ https://www.ncbi.nlm.nih.gov/pubmed/33784371 http://dx.doi.org/10.1371/journal.ppat.1009480 |
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author | Lin, Jhe-Jhih Chung, Pei-Jung Dai, Shih-Syong Tsai, Wan-Ting Lin, Yu-Feng Kuo, Yi-Ping Tsai, Kuen-Nan Chien, Chia-Hao Tsai, De-Jiun Wu, Ming-Sian Shu, Pei-Yun Yueh, Andrew Chen, Hsin-Wei Chen, Chun-Hong Yu, Guann-Yi |
author_facet | Lin, Jhe-Jhih Chung, Pei-Jung Dai, Shih-Syong Tsai, Wan-Ting Lin, Yu-Feng Kuo, Yi-Ping Tsai, Kuen-Nan Chien, Chia-Hao Tsai, De-Jiun Wu, Ming-Sian Shu, Pei-Yun Yueh, Andrew Chen, Hsin-Wei Chen, Chun-Hong Yu, Guann-Yi |
author_sort | Lin, Jhe-Jhih |
collection | PubMed |
description | Dengue virus (DENV) causes dengue fever and severe hemorrhagic fever in humans and is primarily transmitted by Aedes aegypti and A. albopictus mosquitoes. The incidence of DENV infection has been gradually increasing in recent years due to global urbanization and international travel. Understanding the virulence determinants in host and vector transmissibility of emerging epidemic DENV will be critical to combat potential outbreaks. The DENV serotype 2 (DENV-2), which caused a widespread outbreak in Taiwan in 2015 (TW2015), is of the Cosmopolitan genotype and is phylogenetically related to the virus strain linked to another large outbreak in Indonesia in 2015. We found that the TW2015 virus was highly virulent in type I and type II interferon-deficient mice, with robust replication in spleen, lung, and intestine. The TW2015 virus also had high transmissibility to Aedes mosquitoes and could be effectively spread in a continuous mosquitoes-mouse-mosquitoes-mouse transmission cycle. By making 16681-based mutants carrying different segments of the TW2015 virus, we identified the structural pre-membrane (prM) and envelope (E) genes as key virulence determinants in the host, with involvement in the high transmissibility of the TW2015 virus in mosquitoes. The transmission mouse model will make a useful platform for evaluation of DENV with high epidemic potential and development of new strategies against dengue outbreaks. |
format | Online Article Text |
id | pubmed-8034735 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-80347352021-04-15 Aggressive organ penetration and high vector transmissibility of epidemic dengue virus-2 Cosmopolitan genotype in a transmission mouse model Lin, Jhe-Jhih Chung, Pei-Jung Dai, Shih-Syong Tsai, Wan-Ting Lin, Yu-Feng Kuo, Yi-Ping Tsai, Kuen-Nan Chien, Chia-Hao Tsai, De-Jiun Wu, Ming-Sian Shu, Pei-Yun Yueh, Andrew Chen, Hsin-Wei Chen, Chun-Hong Yu, Guann-Yi PLoS Pathog Research Article Dengue virus (DENV) causes dengue fever and severe hemorrhagic fever in humans and is primarily transmitted by Aedes aegypti and A. albopictus mosquitoes. The incidence of DENV infection has been gradually increasing in recent years due to global urbanization and international travel. Understanding the virulence determinants in host and vector transmissibility of emerging epidemic DENV will be critical to combat potential outbreaks. The DENV serotype 2 (DENV-2), which caused a widespread outbreak in Taiwan in 2015 (TW2015), is of the Cosmopolitan genotype and is phylogenetically related to the virus strain linked to another large outbreak in Indonesia in 2015. We found that the TW2015 virus was highly virulent in type I and type II interferon-deficient mice, with robust replication in spleen, lung, and intestine. The TW2015 virus also had high transmissibility to Aedes mosquitoes and could be effectively spread in a continuous mosquitoes-mouse-mosquitoes-mouse transmission cycle. By making 16681-based mutants carrying different segments of the TW2015 virus, we identified the structural pre-membrane (prM) and envelope (E) genes as key virulence determinants in the host, with involvement in the high transmissibility of the TW2015 virus in mosquitoes. The transmission mouse model will make a useful platform for evaluation of DENV with high epidemic potential and development of new strategies against dengue outbreaks. Public Library of Science 2021-03-30 /pmc/articles/PMC8034735/ /pubmed/33784371 http://dx.doi.org/10.1371/journal.ppat.1009480 Text en © 2021 Lin et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Lin, Jhe-Jhih Chung, Pei-Jung Dai, Shih-Syong Tsai, Wan-Ting Lin, Yu-Feng Kuo, Yi-Ping Tsai, Kuen-Nan Chien, Chia-Hao Tsai, De-Jiun Wu, Ming-Sian Shu, Pei-Yun Yueh, Andrew Chen, Hsin-Wei Chen, Chun-Hong Yu, Guann-Yi Aggressive organ penetration and high vector transmissibility of epidemic dengue virus-2 Cosmopolitan genotype in a transmission mouse model |
title | Aggressive organ penetration and high vector transmissibility of epidemic dengue virus-2 Cosmopolitan genotype in a transmission mouse model |
title_full | Aggressive organ penetration and high vector transmissibility of epidemic dengue virus-2 Cosmopolitan genotype in a transmission mouse model |
title_fullStr | Aggressive organ penetration and high vector transmissibility of epidemic dengue virus-2 Cosmopolitan genotype in a transmission mouse model |
title_full_unstemmed | Aggressive organ penetration and high vector transmissibility of epidemic dengue virus-2 Cosmopolitan genotype in a transmission mouse model |
title_short | Aggressive organ penetration and high vector transmissibility of epidemic dengue virus-2 Cosmopolitan genotype in a transmission mouse model |
title_sort | aggressive organ penetration and high vector transmissibility of epidemic dengue virus-2 cosmopolitan genotype in a transmission mouse model |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8034735/ https://www.ncbi.nlm.nih.gov/pubmed/33784371 http://dx.doi.org/10.1371/journal.ppat.1009480 |
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