C9orf72-derived arginine-containing dipeptide repeats associate with axonal transport machinery and impede microtubule-based motility

A hexanucleotide repeat expansion in the C9orf72 gene is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). How this mutation leads to these neurodegenerative diseases remains unclear. Here, we show using patient stem cell–derived motor neurons th...

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Detalles Bibliográficos
Autores principales: Fumagalli, Laura, Young, Florence L., Boeynaems, Steven, De Decker, Mathias, Mehta, Arpan R., Swijsen, Ann, Fazal, Raheem, Guo, Wenting, Moisse, Matthieu, Beckers, Jimmy, Dedeene, Lieselot, Selvaraj, Bhuvaneish T., Vandoorne, Tijs, Madan, Vanesa, van Blitterswijk, Marka, Raitcheva, Denitza, McCampbell, Alexander, Poesen, Koen, Gitler, Aaron D., Koch, Philipp, Berghe, Pieter Vanden, Thal, Dietmar Rudolf, Verfaillie, Catherine, Chandran, Siddharthan, Van Den Bosch, Ludo, Bullock, Simon L., Van Damme, Philip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8034861/
https://www.ncbi.nlm.nih.gov/pubmed/33837088
http://dx.doi.org/10.1126/sciadv.abg3013

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