Chronic metformin treatment decreases cardiac injury during ischemia-reperfusion by attenuating endoplasmic reticulum stress with improved mitochondrial function

Aging impairs mitochondrial function that leads to greater cardiac injury during ischemia and reperfusion. Cardiac endoplasm reticulum (ER) stress increases with age and contributes to mitochondrial dysfunction. Metformin is an anti-diabetic drug that protects cardiac mitochondria during acute ER st...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Qun, Thompson, Jeremy, Hu, Ying, Lesnefsky, Edward J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8034968/
https://www.ncbi.nlm.nih.gov/pubmed/33746115
http://dx.doi.org/10.18632/aging.202858

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8034968/
https://www.ncbi.nlm.nih.gov/pubmed/33746115
http://dx.doi.org/10.18632/aging.202858

Ejemplares similares