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Complementary biosensors reveal different G-protein signaling modes triggered by GPCRs and non-receptor activators
It has become evident that activation of heterotrimeric G-proteins by cytoplasmic proteins that are not G-protein-coupled receptors (GPCRs) plays a role in physiology and disease. Despite sharing the same biochemical guanine nucleotide exchange factor (GEF) activity as GPCRs in vitro, the mechanisms...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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eLife Sciences Publications, Ltd
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8034979/ https://www.ncbi.nlm.nih.gov/pubmed/33787494 http://dx.doi.org/10.7554/eLife.65620 |