Low-Dose Prednisone Treatment for IVIG-Resistant Kawasaki Disease with Severe Arthritis and Joint Effusion in Two 3-Year-Old Children

Kawasaki disease (KD) is a global disease in children. The etiology and pathogenesis are unknown. Complications vary among patients. Fever can persist in some after immune globulin (IVIG) administration, termed IVIG-resistant KD. Here, we report two cases of IVIG-resistant KD with severe arthritis....

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Detalles Bibliográficos
Autores principales: Fan, Lingling, Lv, Huimin, Jiang, Shujuan, Qin, Daogang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8034992/
https://www.ncbi.nlm.nih.gov/pubmed/33868737
http://dx.doi.org/10.1155/2021/6618346
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author Fan, Lingling
Lv, Huimin
Jiang, Shujuan
Qin, Daogang
author_facet Fan, Lingling
Lv, Huimin
Jiang, Shujuan
Qin, Daogang
author_sort Fan, Lingling
collection PubMed
description Kawasaki disease (KD) is a global disease in children. The etiology and pathogenesis are unknown. Complications vary among patients. Fever can persist in some after immune globulin (IVIG) administration, termed IVIG-resistant KD. Here, we report two cases of IVIG-resistant KD with severe arthritis. The diagnosis of arthritis was confirmed by magnetic resonance imaging (MRI) showing joint effusion. Remarkably, fever and joint pain had not receded after the second dose of IVIG. To further manage the symptoms, we prescribed low-dose oral prednisone with success. Both fever and joint pain were diminished. We ponder that the low-dose prednisone might be an option to treat IVIG-resistant KD with severe arthritis.
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spelling pubmed-80349922021-04-16 Low-Dose Prednisone Treatment for IVIG-Resistant Kawasaki Disease with Severe Arthritis and Joint Effusion in Two 3-Year-Old Children Fan, Lingling Lv, Huimin Jiang, Shujuan Qin, Daogang Case Rep Pediatr Case Report Kawasaki disease (KD) is a global disease in children. The etiology and pathogenesis are unknown. Complications vary among patients. Fever can persist in some after immune globulin (IVIG) administration, termed IVIG-resistant KD. Here, we report two cases of IVIG-resistant KD with severe arthritis. The diagnosis of arthritis was confirmed by magnetic resonance imaging (MRI) showing joint effusion. Remarkably, fever and joint pain had not receded after the second dose of IVIG. To further manage the symptoms, we prescribed low-dose oral prednisone with success. Both fever and joint pain were diminished. We ponder that the low-dose prednisone might be an option to treat IVIG-resistant KD with severe arthritis. Hindawi 2021-04-02 /pmc/articles/PMC8034992/ /pubmed/33868737 http://dx.doi.org/10.1155/2021/6618346 Text en Copyright © 2021 Lingling Fan et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Fan, Lingling
Lv, Huimin
Jiang, Shujuan
Qin, Daogang
Low-Dose Prednisone Treatment for IVIG-Resistant Kawasaki Disease with Severe Arthritis and Joint Effusion in Two 3-Year-Old Children
title Low-Dose Prednisone Treatment for IVIG-Resistant Kawasaki Disease with Severe Arthritis and Joint Effusion in Two 3-Year-Old Children
title_full Low-Dose Prednisone Treatment for IVIG-Resistant Kawasaki Disease with Severe Arthritis and Joint Effusion in Two 3-Year-Old Children
title_fullStr Low-Dose Prednisone Treatment for IVIG-Resistant Kawasaki Disease with Severe Arthritis and Joint Effusion in Two 3-Year-Old Children
title_full_unstemmed Low-Dose Prednisone Treatment for IVIG-Resistant Kawasaki Disease with Severe Arthritis and Joint Effusion in Two 3-Year-Old Children
title_short Low-Dose Prednisone Treatment for IVIG-Resistant Kawasaki Disease with Severe Arthritis and Joint Effusion in Two 3-Year-Old Children
title_sort low-dose prednisone treatment for ivig-resistant kawasaki disease with severe arthritis and joint effusion in two 3-year-old children
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8034992/
https://www.ncbi.nlm.nih.gov/pubmed/33868737
http://dx.doi.org/10.1155/2021/6618346
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