Cargando…

Cellular FLICE-like inhibitory protein (cFLIP) critically maintains apoptotic resistance in human lens epithelial cells

The present study aims to understand the mechanism of the lens epithelial cell’s strong anti-apoptotic capacity and survival in the mature human lens that, on the one hand, maintains lens transparency over several decades, while on the other hand, increases the risk of posterior capsule opacificatio...

Descripción completa

Detalles Bibliográficos
Autores principales:	Huangfu, Jingru, Hao, Caili, Wei, Zongbo, Wormstone, I. Michael, Yan, Hong, Fan, Xingjun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8035156/ https://www.ncbi.nlm.nih.gov/pubmed/33837174 http://dx.doi.org/10.1038/s41419-021-03683-y

Ejemplares similares

cFLIP critically modulates apoptotic resistance in epithelial-to-mesenchymal transition
por: Padmanabhan, Chandrasekhar, et al.
Publicado: (2017)

Expression and localization of cellular FLICE-like inhibitory protein (cFLIP), an anti-apoptotic factor, in corpora lutea during the estrous cycle and pregnancy in Thai swamp buffalo (Bubalus bubalis)
por: WONGPANIT, Kannika, et al.
Publicado: (2019)

Aged Lens Epithelial Cells Suppress Proliferation and Epithelial–Mesenchymal Transition-Relevance for Posterior Capsule Opacification
por: Wei, Zongbo, et al.
Publicado: (2022)

Distinct Activation Mechanisms of NF-κB Regulator Inhibitor of NF-κB Kinase (IKK) by Isoforms of the Cell Death Regulator Cellular FLICE-like Inhibitory Protein (cFLIP)
por: Baratchian, Mehdi, et al.
Publicado: (2016)

FLIP the Switch: Regulation of Apoptosis and Necroptosis by cFLIP
por: Tsuchiya, Yuichi, et al.
Publicado: (2015)

Cellular FLICE-inhibitory protein is required for T cell survival and cycling
por: Chau, Hien, et al.
Publicado: (2005)

Immune Escape of Tumors in Vivo by Expression of Cellular Flice-Inhibitory Protein
por: Medema, Jan Paul, et al.
Publicado: (1999)

cFLIP expression is altered in severe corticosteroid-resistant asthma
por: Lazarev, Dennis, et al.
Publicado: (2014)

cFLIP overexpression in T cells in thymoma-associated myasthenia gravis
por: Belharazem, Djeda, et al.
Publicado: (2015)

Panbinostat decreases cFLIP and enhances killing of cancer cells by immunotoxin LMB-100 by stimulating the extrinsic apoptotic pathway
por: Liu, Xiu-Fen, et al.
Publicado: (2017)

Identification and Characterization of the Interaction Site between cFLIP(L) and Calmodulin
por: Gaidos, Gabriel, et al.
Publicado: (2015)

Regulation of the antiapoptotic protein cFLIP by the glucocorticoid Dexamethasone in ALL cells
por: Kleinesudeik, Lara, et al.
Publicado: (2018)

Superoxide induced inhibition of death receptor signaling is mediated via induced expression of apoptosis inhibitory protein cFLIP
por: Hirpara, Jayshree L., et al.
Publicado: (2019)

Increased cFLIP expression in thymic epithelial tumors blocks autophagy via NF-κB signalling
por: Belharazem, Djeda, et al.
Publicado: (2017)

Accelerated degradation of cFLIP(L) and sensitization of the TRAIL DISC-mediated apoptotic cascade by pinoresinol, a lignan isolated from Rubia philippinensis
por: Lee, So-Ra, et al.
Publicado: (2019)

Computational modelling of LY303511 and TRAIL-induced apoptosis suggests dynamic regulation of cFLIP
por: Shi, Yuan, et al.
Publicado: (2013)

FLIP (Flice-like inhibitory protein) suppresses cytoplasmic double-stranded-RNA-induced apoptosis and NF-κB and IRF3-mediated signaling
por: Handa, Priya, et al.
Publicado: (2011)

Activation of autophagy flux by metformin downregulates cellular FLICE–like inhibitory protein and enhances TRAIL- induced apoptosis
por: Nazim, Uddin MD, et al.
Publicado: (2016)

Emodin Suppresses Hyperglycemia-Induced Proliferation and Fibronectin Expression in Mesangial Cells via Inhibiting cFLIP
por: Gao, Junjie, et al.
Publicado: (2014)

Selective CDK9 inhibition overcomes TRAIL resistance by concomitant suppression of cFlip and Mcl-1
por: Lemke, J, et al.
Publicado: (2014)

Withanolide E sensitizes renal carcinoma cells to TRAIL-induced apoptosis by increasing cFLIP degradation
por: Henrich, C J, et al.
Publicado: (2015)

FADD regulates NF-κB activation and promotes ubiquitination of cFLIP(L) to induce apoptosis
por: Ranjan, Kishu, et al.
Publicado: (2016)

TNF Is Partially Required for Cell-Death-Triggered Skin Inflammation upon Acute Loss of cFLIP
por: Feoktistova, Maria, et al.
Publicado: (2020)

cFLIP downregulation is an early event required for endoplasmic reticulum stress-induced apoptosis in tumor cells
por: Mora-Molina, Rocío, et al.
Publicado: (2022)

Induction of Breast Cancer Cell Apoptosis by TRAIL and Smac Mimetics: Involvement of RIP1 and cFLIP
por: Holmgren, Christian, et al.
Publicado: (2022)

Association of TRAF2 with the short form of cellular FLICE-like inhibitory protein prevents TNFR1-mediated apoptosis
por: Kim, Dong-Joon, et al.
Publicado: (2008)

Inhibition of Methyltransferases Accelerates Degradation of cFLIP and Sensitizes B-Cell Lymphoma Cells to TRAIL-Induced Apoptosis
por: Braun, Frank K., et al.
Publicado: (2015)

Independent Induction of Caspase-8 and cFLIP Expression during Colorectal Carcinogenesis in Sporadic and HNPCC Adenomas and Carcinomas
por: Heijink, D. M., et al.
Publicado: (2007)

YM155 sensitizes HeLa cells to TRAIL-mediated apoptosis via cFLIP and survivin downregulation
por: Chandrasekaran, Arun Pandian, et al.
Publicado: (2020)

Cleavage of cFLIP restrains cell death during viral infection and tissue injury and favors tissue repair
por: Martinez Lagunas, Kristel, et al.
Publicado: (2023)

Mitotic Activation Around Wound Edges and Epithelialization Repair in UVB-Induced Capsular Cataracts
por: Wei, Zongbo, et al.
Publicado: (2021)

Ophiopogonin B sensitizes TRAIL-induced apoptosis through activation of autophagy flux and downregulates cellular FLICE-like inhibitory protein
por: Nazim, Uddin MD., et al.
Publicado: (2017)

Flice-Inhibitory Protein Is a Key Regulator of Germinal Center B Cell Apoptosis
por: Hennino, Ana, et al.
Publicado: (2001)

Kaposi's sarcoma associated herpesvirus-encoded viral FLICE inhibitory protein (vFLIP) K13 suppresses CXCR4 expression by upregulating miR-146a
por: Punj, Vasu, et al.
Publicado: (2009)

Expressions of IGFBP-5, cFLIP in cervical intraepithelial neoplasia, cervical carcinoma and their clinical significances: a molecular pathology
por: Hou, Xue-Jing, et al.
Publicado: (2009)

Cytoplasmic levels of cFLIP determine a broad susceptibility of breast cancer stem/progenitor-like cells to TRAIL
por: French, Rhiannon, et al.
Publicado: (2015)

MCPIP1 Enhances TNF-α-Mediated Apoptosis through Downregulation of the NF-κB/cFLIP Axis
por: Suk, Fat-Moon, et al.
Publicado: (2021)

Mouse Lung Fibroblast Resistance to Fas-Mediated Apoptosis Is Dependent on the Baculoviral Inhibitor of Apoptosis Protein 4 and the Cellular FLICE-Inhibitory Protein
por: Predescu, Sanda A., et al.
Publicado: (2017)

Inhibition of Death Receptor Signaling by Flice-Inhibitory Protein as a Mechanism for Immune Escape of Tumors
por: French, Lars E., et al.
Publicado: (1999)

Flice-Inhibitory Protein Expression during Macrophage Differentiation Confers Resistance to FAS-Mediated Apoptosis
por: Perlman, Harris, et al.
Publicado: (1999)

Cannot write session to /tmp/vufind_sessions/sess_mujp4p3s14ejdq870ank4robpo