Lipid nanoparticle encapsulated nucleoside-modified mRNA vaccines elicit polyfunctional HIV-1 antibodies comparable to proteins in nonhuman primates

The development of an effective AIDS vaccine remains a challenge. Nucleoside-modified mRNAs formulated in lipid nanoparticles (mRNA-LNP) have proved to be a potent mode of immunization against infectious diseases in preclinical studies, and are being tested for SARS-CoV-2 in humans. A critical quest...

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Detalles Bibliográficos
Autores principales: Saunders, Kevin O., Pardi, Norbert, Parks, Robert, Santra, Sampa, Mu, Zekun, Sutherland, Laura, Scearce, Richard, Barr, Maggie, Eaton, Amanda, Hernandez, Giovanna, Goodman, Derrick, Hogan, Michael J., Tombacz, Istvan, Gordon, David N., Rountree, R. Wes, Wang, Yunfei, Lewis, Mark G., Pierson, Theodore C., Barbosa, Chris, Tam, Ying, Matyas, Gary R., Rao, Mangala, Beck, Zoltan, Shen, Xiaoying, Ferrari, Guido, Tomaras, Georgia D., Montefiori, David C., Weissman, Drew, Haynes, Barton F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8035178/
https://www.ncbi.nlm.nih.gov/pubmed/33837212
http://dx.doi.org/10.1038/s41541-021-00307-6

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