Physiological role for GABA(A) receptor desensitization in the induction of long-term potentiation at inhibitory synapses

GABA(A) receptors (GABA(A)Rs) are pentameric ligand-gated ion channels distributed throughout the brain where they mediate synaptic and tonic inhibition. Following activation, these receptors undergo desensitization which involves entry into long-lived agonist-bound closed states. Although the kinet...

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Detalles Bibliográficos
Autores principales: Field, Martin, Dorovykh, Valentina, Thomas, Philip, Smart, Trevor G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8035410/
https://www.ncbi.nlm.nih.gov/pubmed/33837214
http://dx.doi.org/10.1038/s41467-021-22420-9

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