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Enhancement of Pharmaceutical Urate Oxidase Thermostability by Rational Design of De Novo Disulfide Bridge

BACKGROUND AND PURPOSE: As a therapeutic enzyme, urate oxidase is utilized in the reduction of uric acid in various conditions such as gout or tumor syndrome lysis. However, even bearing kinetical advantage over other counterparts, it suffers from structural instability most likely due to its subcel...

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Detalles Bibliográficos
Autores principales:	Rezaeian Marjani, Leila, Imani, Mehdi, Zarei Jaliani, Hossein
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Institute of Genetic Engineering and Biotechnology 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8035418/ https://www.ncbi.nlm.nih.gov/pubmed/33850949 http://dx.doi.org/10.30498/IJB.2020.2662

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