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The role of interindividual licking received and dopamine genotype on later‐life licking provisioning in female rat offspring

INTRODUCTION: Rat mothers exhibit natural variations in care that propagate between generations of female offspring. However, there is limited information on genetic variation that could influence this propagation. METHODS: We assessed early‐life maternal care received by individual female rat offsp...

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Autores principales: Lauby, Samantha C., Ashbrook, David G., Malik, Hannan R., Chatterjee, Diptendu, Pan, Pauline, Fleming, Alison S., McGowan, Patrick O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8035462/
https://www.ncbi.nlm.nih.gov/pubmed/33560574
http://dx.doi.org/10.1002/brb3.2069
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author Lauby, Samantha C.
Ashbrook, David G.
Malik, Hannan R.
Chatterjee, Diptendu
Pan, Pauline
Fleming, Alison S.
McGowan, Patrick O.
author_facet Lauby, Samantha C.
Ashbrook, David G.
Malik, Hannan R.
Chatterjee, Diptendu
Pan, Pauline
Fleming, Alison S.
McGowan, Patrick O.
author_sort Lauby, Samantha C.
collection PubMed
description INTRODUCTION: Rat mothers exhibit natural variations in care that propagate between generations of female offspring. However, there is limited information on genetic variation that could influence this propagation. METHODS: We assessed early‐life maternal care received by individual female rat offspring, later‐life maternal care provisioning, and dopaminergic activity in the maternal brain in relation to naturally occurring genetic polymorphisms linked to the dopaminergic system. We also conducted a systematic analysis of other genetic variants potentially related to maternal behavior in our Long‐Evans rat population. RESULTS: While we did not find a direct relationship between early‐life licking received and later‐life licking provisioning, this relationship was indirectly affected by dopamine levels in the nucleus accumbens and dependent on variation in the dopamine receptor 2 gene (rs107017253). More specifically, female rat offspring with the A/G genotype showed a positive relationship between average licking received and dopamine levels in the nucleus accumbens of the maternal brain; there was no relationship with female rat offspring with the A/A genotype. The higher dopamine levels in the nucleus accumbens corresponded with higher maternal licking provisioning from postnatal days 2–9. We also discovered and validated several new variants that were predicted by our systematic analysis. CONCLUSION: Our findings suggest that genetic variation influences the relationship between early‐life maternal care received and the dopaminergic system of the maternal brain, which can indirectly influence later‐life maternal care provisioning.
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spelling pubmed-80354622021-04-14 The role of interindividual licking received and dopamine genotype on later‐life licking provisioning in female rat offspring Lauby, Samantha C. Ashbrook, David G. Malik, Hannan R. Chatterjee, Diptendu Pan, Pauline Fleming, Alison S. McGowan, Patrick O. Brain Behav Original Research INTRODUCTION: Rat mothers exhibit natural variations in care that propagate between generations of female offspring. However, there is limited information on genetic variation that could influence this propagation. METHODS: We assessed early‐life maternal care received by individual female rat offspring, later‐life maternal care provisioning, and dopaminergic activity in the maternal brain in relation to naturally occurring genetic polymorphisms linked to the dopaminergic system. We also conducted a systematic analysis of other genetic variants potentially related to maternal behavior in our Long‐Evans rat population. RESULTS: While we did not find a direct relationship between early‐life licking received and later‐life licking provisioning, this relationship was indirectly affected by dopamine levels in the nucleus accumbens and dependent on variation in the dopamine receptor 2 gene (rs107017253). More specifically, female rat offspring with the A/G genotype showed a positive relationship between average licking received and dopamine levels in the nucleus accumbens of the maternal brain; there was no relationship with female rat offspring with the A/A genotype. The higher dopamine levels in the nucleus accumbens corresponded with higher maternal licking provisioning from postnatal days 2–9. We also discovered and validated several new variants that were predicted by our systematic analysis. CONCLUSION: Our findings suggest that genetic variation influences the relationship between early‐life maternal care received and the dopaminergic system of the maternal brain, which can indirectly influence later‐life maternal care provisioning. John Wiley and Sons Inc. 2021-02-09 /pmc/articles/PMC8035462/ /pubmed/33560574 http://dx.doi.org/10.1002/brb3.2069 Text en © 2021 The Authors. Brain and Behavior published by Wiley Periodicals LLC https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Lauby, Samantha C.
Ashbrook, David G.
Malik, Hannan R.
Chatterjee, Diptendu
Pan, Pauline
Fleming, Alison S.
McGowan, Patrick O.
The role of interindividual licking received and dopamine genotype on later‐life licking provisioning in female rat offspring
title The role of interindividual licking received and dopamine genotype on later‐life licking provisioning in female rat offspring
title_full The role of interindividual licking received and dopamine genotype on later‐life licking provisioning in female rat offspring
title_fullStr The role of interindividual licking received and dopamine genotype on later‐life licking provisioning in female rat offspring
title_full_unstemmed The role of interindividual licking received and dopamine genotype on later‐life licking provisioning in female rat offspring
title_short The role of interindividual licking received and dopamine genotype on later‐life licking provisioning in female rat offspring
title_sort role of interindividual licking received and dopamine genotype on later‐life licking provisioning in female rat offspring
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8035462/
https://www.ncbi.nlm.nih.gov/pubmed/33560574
http://dx.doi.org/10.1002/brb3.2069
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