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Design, synthesis and evaluation of novel enzalutamide analogues as potential anticancer agents

The androgen receptor inhibitor, Enzalutamide, proved effective against castration resistance prostate cancer, has demonstrated clinical benefits and increased survival rate in men. However, AR mutation (F876L) converts Enzalutamide from antagonist to agonist indicating a rapid evolution of resistan...

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Detalles Bibliográficos
Autores principales:	Bhole, Ritesh P., Chikhale, Rupesh V., Wavhale, Ravindra D., Asmary, Fatmah Ali, Almutairi, Tahani Mazyad, Alhajri, Hassna Mohammed, Bonde, Chandrakant G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8035491/ https://www.ncbi.nlm.nih.gov/pubmed/33869816 http://dx.doi.org/10.1016/j.heliyon.2021.e06227

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