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Syphilitic hepatitis; a rare manifestation of a common disease

Syphilis is a sexual transmitted disease caused by Treponema pallidum and an underdiagnosed and underreported cause of acute hepatitis. In recent years, reported cases of primary and secondary syphilis have been increasing, mostly in men who have sex with men. Clinical manifestations of syphilis are...

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Autores principales: Pereira, Flávio G., Leal, Mariana S., Meireles, Daniela, Cavadas, Susana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shaheed Beheshti University of Medical Sciences 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8035539/
https://www.ncbi.nlm.nih.gov/pubmed/33868613
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author Pereira, Flávio G.
Leal, Mariana S.
Meireles, Daniela
Cavadas, Susana
author_facet Pereira, Flávio G.
Leal, Mariana S.
Meireles, Daniela
Cavadas, Susana
author_sort Pereira, Flávio G.
collection PubMed
description Syphilis is a sexual transmitted disease caused by Treponema pallidum and an underdiagnosed and underreported cause of acute hepatitis. In recent years, reported cases of primary and secondary syphilis have been increasing, mostly in men who have sex with men. Clinical manifestations of syphilis are diverse, earning the name of “the great imitator” which can affect virtually any organ. Nonetheless, hepatic involvement is rare, but it can occur at any stage of the disease. We present the case of a 41-year-old immunocompetent male, that presents to us with a cholestatic hepatitis and a diffuse erythematous rash with palmo-plantar affection. The patient had no history of primary syphilis. After throughout aetiologic study, he was diagnosed with syphilitic hepatitis and treated with intramuscular Benzathine benzylpenicillin, with the disappearance of the rash and normalization of liver enzymes after 3 months. We would like to highlight that this aetiology should be considered in patients with unexplained elevation of liver enzymes (mainly cholestatic enzymes) and an epidemiologic context of unsafe sexual exposure.
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spelling pubmed-80355392021-04-16 Syphilitic hepatitis; a rare manifestation of a common disease Pereira, Flávio G. Leal, Mariana S. Meireles, Daniela Cavadas, Susana Gastroenterol Hepatol Bed Bench Case Report Syphilis is a sexual transmitted disease caused by Treponema pallidum and an underdiagnosed and underreported cause of acute hepatitis. In recent years, reported cases of primary and secondary syphilis have been increasing, mostly in men who have sex with men. Clinical manifestations of syphilis are diverse, earning the name of “the great imitator” which can affect virtually any organ. Nonetheless, hepatic involvement is rare, but it can occur at any stage of the disease. We present the case of a 41-year-old immunocompetent male, that presents to us with a cholestatic hepatitis and a diffuse erythematous rash with palmo-plantar affection. The patient had no history of primary syphilis. After throughout aetiologic study, he was diagnosed with syphilitic hepatitis and treated with intramuscular Benzathine benzylpenicillin, with the disappearance of the rash and normalization of liver enzymes after 3 months. We would like to highlight that this aetiology should be considered in patients with unexplained elevation of liver enzymes (mainly cholestatic enzymes) and an epidemiologic context of unsafe sexual exposure. Shaheed Beheshti University of Medical Sciences 2021 /pmc/articles/PMC8035539/ /pubmed/33868613 Text en ©2021 RIGLD, Research Institute for Gastroenterology and Liver Diseases https://creativecommons.org/licenses/by/3.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/ (https://creativecommons.org/licenses/by/3.0/) ) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Pereira, Flávio G.
Leal, Mariana S.
Meireles, Daniela
Cavadas, Susana
Syphilitic hepatitis; a rare manifestation of a common disease
title Syphilitic hepatitis; a rare manifestation of a common disease
title_full Syphilitic hepatitis; a rare manifestation of a common disease
title_fullStr Syphilitic hepatitis; a rare manifestation of a common disease
title_full_unstemmed Syphilitic hepatitis; a rare manifestation of a common disease
title_short Syphilitic hepatitis; a rare manifestation of a common disease
title_sort syphilitic hepatitis; a rare manifestation of a common disease
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8035539/
https://www.ncbi.nlm.nih.gov/pubmed/33868613
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