Cargando…

Effect of Synchronous Versus Sequential Regimens on the Pharmacokinetics and Biodistribution of Regorafenib with Irradiation

This study was performed to evaluate the interaction between conventional or high-dose radiotherapy (RT) and the pharmacokinetics (PK) of regorafenib in concurrent or sequential regimens for the treatment of hepatocellular carcinoma. Concurrent and sequential in vitro and in vivo studies of irradiat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tsai, Tung-Hu, Chen, Yu-Jen, Wang, Li-Ying, Hsieh, Chen-Hsi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8035703/ https://www.ncbi.nlm.nih.gov/pubmed/33805831 http://dx.doi.org/10.3390/pharmaceutics13030386

Ejemplares similares

Impact of Local Liver Irradiation Concurrent Versus Sequential with Lenvatinib on Pharmacokinetics and Biodistribution
por: Tsai, Tung-Hu, et al.
Publicado: (2021)

Local Liver Irradiation Concurrently Versus Sequentially with Cabozantinib on the Pharmacokinetics and Biodistribution in Rats
por: Huang, Yu-Chuen, et al.
Publicado: (2023)

Local Irradiation Modulates the Pharmacokinetics of Metabolites in 5-Fluorouracil—Radiotherapy–Pharmacokinetics Phenomenon
por: Liu, Ju-Han, et al.
Publicado: (2020)

Impact of Irradiation on the Pharmacokinetics and Biotransformation of Tamoxifen
por: Cheng, Yung-Yi, et al.
Publicado: (2022)

Local pelvic irradiation modulates Pharmacokinetics of 5-Fluorouracil in the plasma but not in the Lymphatic System
por: Hsieh, Chen-Hsi, et al.
Publicado: (2015)

Abdominal irradiation modulates 5-Fluorouracil pharmacokinetics
por: Hsieh, Chen-Hsi, et al.
Publicado: (2010)

Head and neck irradiation modulates pharmacokinetics of 5-fluorouracil and cisplatin
por: Hsieh, Chen-Hsi, et al.
Publicado: (2013)

Matrix Metalloproteinase-8 Mediates the Unfavorable Systemic Impact of Local Irradiation on Pharmacokinetics of Anti-Cancer Drug 5-Fluorouracil
por: Hsieh, Chen-Hsi, et al.
Publicado: (2011)

An Observational Study of Trifluridine/Tipiracil-Containing Regimen Versus Regorafenib-Containing Regimen in Patients With Metastatic Colorectal Cancer
por: Hsieh, Meng-Che, et al.
Publicado: (2022)

Local Radiotherapy Affects Drug Pharmacokinetics—Exploration of a Neglected but Significant Uncertainty of Cancer Therapy
por: Chen, Yu-Jen, et al.
Publicado: (2017)

Correlation between radioactivity and chemotherapeutics of the (111)In-VNB-liposome in pharmacokinetics and biodistribution in rats
por: Lee, Wen-Chuan, et al.
Publicado: (2012)

Interaction Between Sex and Organic Anion‐Transporting Polypeptide 1b2 on the Pharmacokinetics of Regorafenib and Its Metabolites Regorafenib‐N‐Oxide and Regorafenib‐Glucuronide in Mice
por: Fu, Qiang, et al.
Publicado: (2019)

Preclinical Pharmacokinetics of Lamivudine and Its Interaction with Schisandra chinensis Extract in Rats
por: Li, Chi-Lin, et al.
Publicado: (2020)

Concurrent administration of anticancer chemotherapy drug and herbal medicine on the perspective of pharmacokinetics
por: Cheng, Yung-Yi, et al.
Publicado: (2018)

Robust combination of liver stereotactic body radiotherapy modulates pharmacokinetics of sorafenib toward preferable parameters
por: Hsieh, Chen-Hsi, et al.
Publicado: (2020)

Pharmacologic activity and pharmacokinetics of metabolites of regorafenib in preclinical models
por: Zopf, Dieter, et al.
Publicado: (2016)

Preparation, pharmacokinetics and biodistribution of baicalin-loaded liposomes
por: Wei, Yumeng, et al.
Publicado: (2014)

Pharmacokinetics of Schizandrin and Its Pharmaceutical Products Assessed Using a Validated LC–MS/MS Method
por: Li, Chi-Lin, et al.
Publicado: (2018)

Pharmacokinetics and Biodistribution of Zinc-Enriched Yeast in Rats
por: Zhang, Shuangqing, et al.
Publicado: (2014)

Image Guided Biodistribution and Pharmacokinetic Studies of Theranostics
por: Ding, Hong, et al.
Publicado: (2012)

Treatment efficacy and safety of regorafenib plus drug-eluting beads-transarterial chemoembolization versus regorafenib monotherapy in colorectal cancer liver metastasis patients who fail standard treatment regimens
por: Cao, Fei, et al.
Publicado: (2021)

Sorafenib-Regorafenib Sequential Therapy in Japanese Patients with Unresectable Hepatocellular Carcinoma—Relative Dose Intensity and Post-Regorafenib Therapies in Real World Practice
por: Wang, Wan, et al.
Publicado: (2019)

Study on efficacy and safety of transcatheter arterial chemoembolization (TACE) combined with regorafenib and PD-1 antibody versus continued TACE combined with regorafenib in patients with hepatocellular carcinoma after failed second-line treatment with regorafenib
por: Wang, Haochen, et al.
Publicado: (2022)

The Herb–Drug Pharmacokinetic Interaction of 5-Fluorouracil and Its Metabolite 5-Fluoro-5,6-Dihydrouracil with a Traditional Chinese Medicine in Rats
por: Liu, Ju-Han, et al.
Publicado: (2017)

Nivolumab Versus Regorafenib in Patients With Hepatocellular Carcinoma After Sorafenib Failure
por: Kuo, Yuan-Hung, et al.
Publicado: (2021)

Modulating Pharmacokinetics, Tumor Uptake and Biodistribution by Engineered Nanoparticles
por: Arvizo, Rochelle R., et al.
Publicado: (2011)

Pharmacokinetics, Biodistribution, and Biosafety of PEGylated Gold Nanoparticles In Vivo
por: Kozics, Katarina, et al.
Publicado: (2021)

Neonatal Pharmacokinetics and Biodistribution of Polymeric Nanoparticles and Effect of Surfactant
por: Xu, Nuo, et al.
Publicado: (2023)

Pharmacokinetics, biodistribution and toxicology of novel cell-penetrating peptides
por: Reveret, L., et al.
Publicado: (2023)

Effective Sequential Combined Chemotherapy with Trifluridine/Tipiracil and Regorafenib in Human Colorectal Cancer Cells
por: Matsuoka, Kazuaki, et al.
Publicado: (2018)

Regorafenib in Japanese patients with solid tumors: phase I study of safety, efficacy, and pharmacokinetics
por: Sunakawa, Yu, et al.
Publicado: (2013)

A phase 0 study of the pharmacokinetics, biodistribution, and dosimetry of (188)Re-liposome in patients with metastatic tumors
por: Wang, Shyh-Jen, et al.
Publicado: (2019)

Regorafenib treatment outcome for Taiwanese patients with metastatic gastrointestinal stromal tumors after failure of imatinib and sunitinib: A prospective, non-randomized, single-center study
por: Hu, Chia-Hsiang, et al.
Publicado: (2020)

Biochemical modifications of avidin improve pharmacokinetics and biodistribution, and reduce immunogenicity.
por: Chinol, M., et al.
Publicado: (1998)

Pharmacokinetics and biodistribution of Erufosine in nude mice - implications for combination with radiotherapy
por: Henke, Guido, et al.
Publicado: (2009)

Pharmacokinetics and biodistribution of negatively charged pectin nanoparticles encapsulating paclitaxel
por: Verma, Anita K., et al.
Publicado: (2013)

Phosphorylation-specific status of RNAi triggers in pharmacokinetic and biodistribution analyses
por: Trubetskoy, Vladimir S., et al.
Publicado: (2017)

Pharmacokinetics and Biodistribution of Pegylated Methotrexate after IV Administration to Mice
por: Yousefi, Gholamhossein, et al.
Publicado: (2018)

A Review on the Biodistribution, Pharmacokinetics and Toxicity of Bismuth-Based Nanomaterials
por: Badrigilan, Samireh, et al.
Publicado: (2020)

Comparison of whole brain radiation therapy for synchronous brain metastases with irradiation protecting the hippocampus versus whole brain radiotherapy for sequential brain metastases to boost irradiation in the treatment of brain metastases from SCLC: study protocol for a randomized controlled trial
por: Zhang, Xiaofang, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_8p8si7qd3pgba4ia7sajac5b94