Cargando…
OTULIN is a new target of EA treatment in the alleviation of brain injury and glial cell activation via suppression of the NF-κB signalling pathway in acute ischaemic stroke rats
OBJECTIVE: Ovarian tumour domain deubiquitinase with linear linkage specificity (OTULIN) is a potent negative regulator of the nuclear factor-κB (NF-κB) signalling pathway, and it plays a strong neuroprotective role following acute ischemic stroke. Electroacupuncture (EA) is an effective adjuvant tr...
Autores principales: | Xu, Hongbei, Wang, You, Luo, Yong |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8035756/ https://www.ncbi.nlm.nih.gov/pubmed/33836646 http://dx.doi.org/10.1186/s10020-021-00297-0 |
Ejemplares similares
-
Lentivirus-mediated overexpression of OTULIN ameliorates microglia activation and neuroinflammation by depressing the activation of the NF-κB signaling pathway in cerebral ischemia/reperfusion rats
por: Xu, Hongbei, et al.
Publicado: (2018) -
Reciprocal interplay between OTULIN–LUBAC determines genotoxic and inflammatory NF-κB signal responses
por: Li, Mingqi, et al.
Publicado: (2022) -
SNX27-driven membrane localisation of OTULIN antagonises linear ubiquitination and NF-κB signalling activation
por: Shi, Ruona, et al.
Publicado: (2021) -
Molecular Basis and Regulation of OTULIN-LUBAC Interaction
por: Elliott, Paul R., et al.
Publicado: (2014) -
Regulation of the endosomal SNX27-retromer by OTULIN
por: Stangl, Aurelia, et al.
Publicado: (2019)