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Novel perspectives for SARS-CoV-2 genome browsing
SARS-CoV-2 has spread worldwide and caused social, economic, and health turmoil. The first genome assembly of SARS-CoV-2 was produced in Wuhan, and it is widely used as a reference. Subsequently, more than a hundred additional SARS-CoV-2 genomes have been sequenced. While the genomes appear to be mo...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
De Gruyter
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8035962/ https://www.ncbi.nlm.nih.gov/pubmed/33721918 http://dx.doi.org/10.1515/jib-2021-0001 |
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author | Gültekin, Visam Allmer, Jens |
author_facet | Gültekin, Visam Allmer, Jens |
author_sort | Gültekin, Visam |
collection | PubMed |
description | SARS-CoV-2 has spread worldwide and caused social, economic, and health turmoil. The first genome assembly of SARS-CoV-2 was produced in Wuhan, and it is widely used as a reference. Subsequently, more than a hundred additional SARS-CoV-2 genomes have been sequenced. While the genomes appear to be mostly identical, there are variations. Therefore, an alignment of all available genomes and the derived consensus sequence could be used as a reference, better serving the science community. Variations are significant, but representing them in a genome browser can become, especially if their sequences are largely identical. Here we summarize the variation in one track. Other information not currently found in genome browsers for SARS-CoV-2, such as predicted miRNAs and predicted TRS as well as secondary structure information, were also added as tracks to the consensus genome. We believe that a genome browser based on the consensus sequence is better suited when considering worldwide effects and can become a valuable resource in the combating of COVID-19. The genome browser is available at http://cov.iaba.online. |
format | Online Article Text |
id | pubmed-8035962 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | De Gruyter |
record_format | MEDLINE/PubMed |
spelling | pubmed-80359622021-04-20 Novel perspectives for SARS-CoV-2 genome browsing Gültekin, Visam Allmer, Jens J Integr Bioinform Article SARS-CoV-2 has spread worldwide and caused social, economic, and health turmoil. The first genome assembly of SARS-CoV-2 was produced in Wuhan, and it is widely used as a reference. Subsequently, more than a hundred additional SARS-CoV-2 genomes have been sequenced. While the genomes appear to be mostly identical, there are variations. Therefore, an alignment of all available genomes and the derived consensus sequence could be used as a reference, better serving the science community. Variations are significant, but representing them in a genome browser can become, especially if their sequences are largely identical. Here we summarize the variation in one track. Other information not currently found in genome browsers for SARS-CoV-2, such as predicted miRNAs and predicted TRS as well as secondary structure information, were also added as tracks to the consensus genome. We believe that a genome browser based on the consensus sequence is better suited when considering worldwide effects and can become a valuable resource in the combating of COVID-19. The genome browser is available at http://cov.iaba.online. De Gruyter 2021-03-16 /pmc/articles/PMC8035962/ /pubmed/33721918 http://dx.doi.org/10.1515/jib-2021-0001 Text en © 2021 Visam Gültekin et al., published by De Gruyter, Berlin/Boston https://creativecommons.org/licenses/by/4.0/This work is licensed under the Creative Commons Attribution 4.0 International License. |
spellingShingle | Article Gültekin, Visam Allmer, Jens Novel perspectives for SARS-CoV-2 genome browsing |
title | Novel perspectives for SARS-CoV-2 genome browsing |
title_full | Novel perspectives for SARS-CoV-2 genome browsing |
title_fullStr | Novel perspectives for SARS-CoV-2 genome browsing |
title_full_unstemmed | Novel perspectives for SARS-CoV-2 genome browsing |
title_short | Novel perspectives for SARS-CoV-2 genome browsing |
title_sort | novel perspectives for sars-cov-2 genome browsing |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8035962/ https://www.ncbi.nlm.nih.gov/pubmed/33721918 http://dx.doi.org/10.1515/jib-2021-0001 |
work_keys_str_mv | AT gultekinvisam novelperspectivesforsarscov2genomebrowsing AT allmerjens novelperspectivesforsarscov2genomebrowsing |