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Novel perspectives for SARS-CoV-2 genome browsing

SARS-CoV-2 has spread worldwide and caused social, economic, and health turmoil. The first genome assembly of SARS-CoV-2 was produced in Wuhan, and it is widely used as a reference. Subsequently, more than a hundred additional SARS-CoV-2 genomes have been sequenced. While the genomes appear to be mo...

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Autores principales: Gültekin, Visam, Allmer, Jens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: De Gruyter 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8035962/
https://www.ncbi.nlm.nih.gov/pubmed/33721918
http://dx.doi.org/10.1515/jib-2021-0001
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author Gültekin, Visam
Allmer, Jens
author_facet Gültekin, Visam
Allmer, Jens
author_sort Gültekin, Visam
collection PubMed
description SARS-CoV-2 has spread worldwide and caused social, economic, and health turmoil. The first genome assembly of SARS-CoV-2 was produced in Wuhan, and it is widely used as a reference. Subsequently, more than a hundred additional SARS-CoV-2 genomes have been sequenced. While the genomes appear to be mostly identical, there are variations. Therefore, an alignment of all available genomes and the derived consensus sequence could be used as a reference, better serving the science community. Variations are significant, but representing them in a genome browser can become, especially if their sequences are largely identical. Here we summarize the variation in one track. Other information not currently found in genome browsers for SARS-CoV-2, such as predicted miRNAs and predicted TRS as well as secondary structure information, were also added as tracks to the consensus genome. We believe that a genome browser based on the consensus sequence is better suited when considering worldwide effects and can become a valuable resource in the combating of COVID-19. The genome browser is available at http://cov.iaba.online.
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spelling pubmed-80359622021-04-20 Novel perspectives for SARS-CoV-2 genome browsing Gültekin, Visam Allmer, Jens J Integr Bioinform Article SARS-CoV-2 has spread worldwide and caused social, economic, and health turmoil. The first genome assembly of SARS-CoV-2 was produced in Wuhan, and it is widely used as a reference. Subsequently, more than a hundred additional SARS-CoV-2 genomes have been sequenced. While the genomes appear to be mostly identical, there are variations. Therefore, an alignment of all available genomes and the derived consensus sequence could be used as a reference, better serving the science community. Variations are significant, but representing them in a genome browser can become, especially if their sequences are largely identical. Here we summarize the variation in one track. Other information not currently found in genome browsers for SARS-CoV-2, such as predicted miRNAs and predicted TRS as well as secondary structure information, were also added as tracks to the consensus genome. We believe that a genome browser based on the consensus sequence is better suited when considering worldwide effects and can become a valuable resource in the combating of COVID-19. The genome browser is available at http://cov.iaba.online. De Gruyter 2021-03-16 /pmc/articles/PMC8035962/ /pubmed/33721918 http://dx.doi.org/10.1515/jib-2021-0001 Text en © 2021 Visam Gültekin et al., published by De Gruyter, Berlin/Boston https://creativecommons.org/licenses/by/4.0/This work is licensed under the Creative Commons Attribution 4.0 International License.
spellingShingle Article
Gültekin, Visam
Allmer, Jens
Novel perspectives for SARS-CoV-2 genome browsing
title Novel perspectives for SARS-CoV-2 genome browsing
title_full Novel perspectives for SARS-CoV-2 genome browsing
title_fullStr Novel perspectives for SARS-CoV-2 genome browsing
title_full_unstemmed Novel perspectives for SARS-CoV-2 genome browsing
title_short Novel perspectives for SARS-CoV-2 genome browsing
title_sort novel perspectives for sars-cov-2 genome browsing
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8035962/
https://www.ncbi.nlm.nih.gov/pubmed/33721918
http://dx.doi.org/10.1515/jib-2021-0001
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