Induction of Wnt signaling antagonists and p21-activated kinase enhances cardiomyocyte proliferation during zebrafish heart regeneration

Heart regeneration occurs by dedifferentiation and proliferation of pre-existing cardiomyocytes (CMs). However, the signaling mechanisms by which injury induces CM renewal remain incompletely understood. Here, we find that cardiac injury in zebrafish induces expression of the secreted Wnt inhibitors...

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Detalles Bibliográficos
Autores principales: Peng, Xiangwen, Lai, Kaa Seng, She, Peilu, Kang, Junsu, Wang, Tingting, Li, Guobao, Zhou, Yating, Sun, Jianjian, Jin, Daqing, Xu, Xiaolei, Liao, Lujian, Liu, Jiandong, Lee, Ethan, Poss, Kenneth D, Zhong, Tao P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8035995/
https://www.ncbi.nlm.nih.gov/pubmed/33582796
http://dx.doi.org/10.1093/jmcb/mjaa046

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