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Role and therapeutic potential of liquid–liquid phase separation in amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a late-onset neurodegenerative disease selectively affecting motor neurons, leading to progressive paralysis. Although most cases are sporadic, ∼10% are familial. Similar proteins are found in aggregates in sporadic and familial ALS, and over the last decade, r...
Autores principales: | Pakravan, Donya, Orlando, Gabriele, Bercier, Valérie, Van Den Bosch, Ludo |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8036000/ https://www.ncbi.nlm.nih.gov/pubmed/32976566 http://dx.doi.org/10.1093/jmcb/mjaa049 |
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