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A comparative study of functioning and non-functioning pituitary adenomas

Pituitary tumors commonly cause visual impairment and the degree of impairment can depend on the size, location, and type of the tumor. However, no studies have been made regarding the differences caused by functioning pituitary adenoma (FPA) and non-functioning pituitary adenoma (NFPA). We aimed to...

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Autores principales: Qin, Jiayin, Li, Kai, Wang, Xijuan, Bao, Yongzhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8036017/
https://www.ncbi.nlm.nih.gov/pubmed/33832102
http://dx.doi.org/10.1097/MD.0000000000025306
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author Qin, Jiayin
Li, Kai
Wang, Xijuan
Bao, Yongzhen
author_facet Qin, Jiayin
Li, Kai
Wang, Xijuan
Bao, Yongzhen
author_sort Qin, Jiayin
collection PubMed
description Pituitary tumors commonly cause visual impairment and the degree of impairment can depend on the size, location, and type of the tumor. However, no studies have been made regarding the differences caused by functioning pituitary adenoma (FPA) and non-functioning pituitary adenoma (NFPA). We aimed to investigate the relationship between clinical characteristics and visual impairment in patients with FPA and NFPA. This case series study included 73 pituitary adenoma patients. All patients underwent ophthalmic evaluations, and we retrospectively reviewed their medical records. Tumor types were confirmed by histological analysis, and the tumor volume was calculated. Magnetic resonance imaging was used to determine the tumor diameter. The observation indices of the two groups were compared. The correlation between the visual field and tumor volume was analysed using scatter plots. We enrolled 30 patients in the FPA group and 43 in the NFPA group. The first symptoms presented in the eyes in 23% of FPA patients and 41.9% of NFPA patients. The best-corrected visual acuity of the FPA group was better than that of the NFPA group, and 34 (56.7%) and 73 (84.9%) eyes in these groups had visual field defects, respectively. The visual field defects of the FPA patients were lighter than those of the NFPA patients. Except for the anteroposterior diameter, there were no differences in the other parameters of tumor diameter between the groups. The tumor volume of the FPA group was smaller than that of the NFPA group. The tumor size was positively correlated with the mean deviation and negatively correlated with the mean sensitivity in both groups. There was a longer delay between the onset of signs and symptoms and treatment in the FPA group than in the NFPA group. Future studies should focus on visual field defects caused by FPA and NFPA.
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spelling pubmed-80360172021-04-13 A comparative study of functioning and non-functioning pituitary adenomas Qin, Jiayin Li, Kai Wang, Xijuan Bao, Yongzhen Medicine (Baltimore) 3700 Pituitary tumors commonly cause visual impairment and the degree of impairment can depend on the size, location, and type of the tumor. However, no studies have been made regarding the differences caused by functioning pituitary adenoma (FPA) and non-functioning pituitary adenoma (NFPA). We aimed to investigate the relationship between clinical characteristics and visual impairment in patients with FPA and NFPA. This case series study included 73 pituitary adenoma patients. All patients underwent ophthalmic evaluations, and we retrospectively reviewed their medical records. Tumor types were confirmed by histological analysis, and the tumor volume was calculated. Magnetic resonance imaging was used to determine the tumor diameter. The observation indices of the two groups were compared. The correlation between the visual field and tumor volume was analysed using scatter plots. We enrolled 30 patients in the FPA group and 43 in the NFPA group. The first symptoms presented in the eyes in 23% of FPA patients and 41.9% of NFPA patients. The best-corrected visual acuity of the FPA group was better than that of the NFPA group, and 34 (56.7%) and 73 (84.9%) eyes in these groups had visual field defects, respectively. The visual field defects of the FPA patients were lighter than those of the NFPA patients. Except for the anteroposterior diameter, there were no differences in the other parameters of tumor diameter between the groups. The tumor volume of the FPA group was smaller than that of the NFPA group. The tumor size was positively correlated with the mean deviation and negatively correlated with the mean sensitivity in both groups. There was a longer delay between the onset of signs and symptoms and treatment in the FPA group than in the NFPA group. Future studies should focus on visual field defects caused by FPA and NFPA. Lippincott Williams & Wilkins 2021-04-09 /pmc/articles/PMC8036017/ /pubmed/33832102 http://dx.doi.org/10.1097/MD.0000000000025306 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/)
spellingShingle 3700
Qin, Jiayin
Li, Kai
Wang, Xijuan
Bao, Yongzhen
A comparative study of functioning and non-functioning pituitary adenomas
title A comparative study of functioning and non-functioning pituitary adenomas
title_full A comparative study of functioning and non-functioning pituitary adenomas
title_fullStr A comparative study of functioning and non-functioning pituitary adenomas
title_full_unstemmed A comparative study of functioning and non-functioning pituitary adenomas
title_short A comparative study of functioning and non-functioning pituitary adenomas
title_sort comparative study of functioning and non-functioning pituitary adenomas
topic 3700
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8036017/
https://www.ncbi.nlm.nih.gov/pubmed/33832102
http://dx.doi.org/10.1097/MD.0000000000025306
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