Can coronavirus disease 2019 (COVID-19) trigger exacerbation of multiple sclerosis? A retrospective study

The effect of coronavirus disease (COVID-19) on the risk of relapse in multiple sclerosis (MS) have been unknown. In this retrospective study of 41 relapsing-remitting MS patients, number of relapses in pre-defined at risk-period (ARP) was compared with the previous two years. During the previous tw...

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Autores principales: Barzegar, Mahdi, Vaheb, Saeed, Mirmosayyeb, Omid, Afshari-Safavi, Alireza, Nehzat, Nasim, Shaygannejad, Vahid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier B.V. 2021
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8036166/
https://www.ncbi.nlm.nih.gov/pubmed/33979771
http://dx.doi.org/10.1016/j.msard.2021.102947
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author Barzegar, Mahdi
Vaheb, Saeed
Mirmosayyeb, Omid
Afshari-Safavi, Alireza
Nehzat, Nasim
Shaygannejad, Vahid
author_facet Barzegar, Mahdi
Vaheb, Saeed
Mirmosayyeb, Omid
Afshari-Safavi, Alireza
Nehzat, Nasim
Shaygannejad, Vahid
author_sort Barzegar, Mahdi
collection PubMed
description The effect of coronavirus disease (COVID-19) on the risk of relapse in multiple sclerosis (MS) have been unknown. In this retrospective study of 41 relapsing-remitting MS patients, number of relapses in pre-defined at risk-period (ARP) was compared with the previous two years. During the previous two years, a total of 32 attacks was reported, which 5 (15.6%) were during the at-risk period. After adjusting for age and sex, there was an increased risk of attack during ARP compared to the previous two years (RR: 2.566, 95%CI: 1.075-6.124, P=0.034). Our preliminary study suggested that COVID-19 can trigger exacerbation of MS.
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spelling pubmed-80361662021-04-12 Can coronavirus disease 2019 (COVID-19) trigger exacerbation of multiple sclerosis? A retrospective study Barzegar, Mahdi Vaheb, Saeed Mirmosayyeb, Omid Afshari-Safavi, Alireza Nehzat, Nasim Shaygannejad, Vahid Mult Scler Relat Disord Commentary The effect of coronavirus disease (COVID-19) on the risk of relapse in multiple sclerosis (MS) have been unknown. In this retrospective study of 41 relapsing-remitting MS patients, number of relapses in pre-defined at risk-period (ARP) was compared with the previous two years. During the previous two years, a total of 32 attacks was reported, which 5 (15.6%) were during the at-risk period. After adjusting for age and sex, there was an increased risk of attack during ARP compared to the previous two years (RR: 2.566, 95%CI: 1.075-6.124, P=0.034). Our preliminary study suggested that COVID-19 can trigger exacerbation of MS. Published by Elsevier B.V. 2021-07 2021-04-11 /pmc/articles/PMC8036166/ /pubmed/33979771 http://dx.doi.org/10.1016/j.msard.2021.102947 Text en © 2021 Published by Elsevier B.V. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Commentary
Barzegar, Mahdi
Vaheb, Saeed
Mirmosayyeb, Omid
Afshari-Safavi, Alireza
Nehzat, Nasim
Shaygannejad, Vahid
Can coronavirus disease 2019 (COVID-19) trigger exacerbation of multiple sclerosis? A retrospective study
title Can coronavirus disease 2019 (COVID-19) trigger exacerbation of multiple sclerosis? A retrospective study
title_full Can coronavirus disease 2019 (COVID-19) trigger exacerbation of multiple sclerosis? A retrospective study
title_fullStr Can coronavirus disease 2019 (COVID-19) trigger exacerbation of multiple sclerosis? A retrospective study
title_full_unstemmed Can coronavirus disease 2019 (COVID-19) trigger exacerbation of multiple sclerosis? A retrospective study
title_short Can coronavirus disease 2019 (COVID-19) trigger exacerbation of multiple sclerosis? A retrospective study
title_sort can coronavirus disease 2019 (covid-19) trigger exacerbation of multiple sclerosis? a retrospective study
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8036166/
https://www.ncbi.nlm.nih.gov/pubmed/33979771
http://dx.doi.org/10.1016/j.msard.2021.102947
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