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A numerical method for computing interval distributions for an inhomogeneous Poisson point process modified by random dead times

The inhomogeneous Poisson point process is a common model for time series of discrete, stochastic events. When an event from a point process is detected, it may trigger a random dead time in the detector, during which subsequent events will fail to be detected. It can be difficult or impossible to o...

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Autor principal: Peterson, Adam J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8036215/
https://www.ncbi.nlm.nih.gov/pubmed/33742314
http://dx.doi.org/10.1007/s00422-021-00868-8
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author Peterson, Adam J.
author_facet Peterson, Adam J.
author_sort Peterson, Adam J.
collection PubMed
description The inhomogeneous Poisson point process is a common model for time series of discrete, stochastic events. When an event from a point process is detected, it may trigger a random dead time in the detector, during which subsequent events will fail to be detected. It can be difficult or impossible to obtain a closed-form expression for the distribution of intervals between detections, even when the rate function (often referred to as the intensity function) and the dead-time distribution are given. Here, a method is presented to numerically compute the interval distribution expected for any arbitrary inhomogeneous Poisson point process modified by dead times drawn from any arbitrary distribution. In neuroscience, such a point process is used to model trains of neuronal spikes triggered by the detection of excitatory events while the neuron is not refractory. The assumptions of the method are that the process is observed over a finite observation window and that the detector is not in a dead state at the start of the observation window. Simulations are used to verify the method for several example point processes. The method should be useful for modeling and understanding the relationships between the rate functions and interval distributions of the event and detection processes, and how these relationships depend on the dead-time distribution.
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spelling pubmed-80362152021-04-27 A numerical method for computing interval distributions for an inhomogeneous Poisson point process modified by random dead times Peterson, Adam J. Biol Cybern Original Article The inhomogeneous Poisson point process is a common model for time series of discrete, stochastic events. When an event from a point process is detected, it may trigger a random dead time in the detector, during which subsequent events will fail to be detected. It can be difficult or impossible to obtain a closed-form expression for the distribution of intervals between detections, even when the rate function (often referred to as the intensity function) and the dead-time distribution are given. Here, a method is presented to numerically compute the interval distribution expected for any arbitrary inhomogeneous Poisson point process modified by dead times drawn from any arbitrary distribution. In neuroscience, such a point process is used to model trains of neuronal spikes triggered by the detection of excitatory events while the neuron is not refractory. The assumptions of the method are that the process is observed over a finite observation window and that the detector is not in a dead state at the start of the observation window. Simulations are used to verify the method for several example point processes. The method should be useful for modeling and understanding the relationships between the rate functions and interval distributions of the event and detection processes, and how these relationships depend on the dead-time distribution. Springer Berlin Heidelberg 2021-03-19 2021 /pmc/articles/PMC8036215/ /pubmed/33742314 http://dx.doi.org/10.1007/s00422-021-00868-8 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Peterson, Adam J.
A numerical method for computing interval distributions for an inhomogeneous Poisson point process modified by random dead times
title A numerical method for computing interval distributions for an inhomogeneous Poisson point process modified by random dead times
title_full A numerical method for computing interval distributions for an inhomogeneous Poisson point process modified by random dead times
title_fullStr A numerical method for computing interval distributions for an inhomogeneous Poisson point process modified by random dead times
title_full_unstemmed A numerical method for computing interval distributions for an inhomogeneous Poisson point process modified by random dead times
title_short A numerical method for computing interval distributions for an inhomogeneous Poisson point process modified by random dead times
title_sort numerical method for computing interval distributions for an inhomogeneous poisson point process modified by random dead times
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8036215/
https://www.ncbi.nlm.nih.gov/pubmed/33742314
http://dx.doi.org/10.1007/s00422-021-00868-8
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