Targeting Replicative Stress and DNA Repair by Combining PARP and Wee1 Kinase Inhibitors Is Synergistic in Triple Negative Breast Cancers with Cyclin E or BRCA1 Alteration

SIMPLE SUMMARY: Triple-negative breast cancer (TNBC) is a subtype of invasive breast cancer with an aggressive phenotype that has decreased survival compared with other types of breast cancers, due in part to the lack of biomarker driven targeted therapies. Here, we show that breast cancer patients...

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Detalles Bibliográficos
Autores principales: Chen, Xian, Yang, Dong, Carey, Jason P. W., Karakas, Cansu, Albarracin, Constance, Sahin, Aysegul A., Arun, Banu K., Guray Durak, Merih, Li, Mi, Kohansal, Mehrnoosh, Bui, Tuyen N., Ha, Min-Jin, Hunt, Kelly K., Keyomarsi, Khandan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8036262/
https://www.ncbi.nlm.nih.gov/pubmed/33916118
http://dx.doi.org/10.3390/cancers13071656

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