Cargando…

Exogenous Integrin αIIbβ3 Inhibitors Revisited: Past, Present and Future Applications

The integrin αIIbβ3 is the most abundant integrin on platelets. Upon platelet activation, the integrin changes its conformation (inside-out signalling) and outside-in signalling takes place leading to platelet spreading, platelet aggregation and thrombus formation. Bloodsucking parasites such as mos...

Descripción completa

Detalles Bibliográficos
Autores principales:	van den Kerkhof, Danique L., van der Meijden, Paola E.J., Hackeng, Tilman M., Dijkgraaf, Ingrid
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8036306/ https://www.ncbi.nlm.nih.gov/pubmed/33806083 http://dx.doi.org/10.3390/ijms22073366

Ejemplares similares

Inhibition of platelet adhesion, thrombus formation, and fibrin formation by a potent αIIbβ3 integrin inhibitor from ticks
por: van den Kerkhof, Danique L., et al.
Publicado: (2020)

Key role of integrin α(IIb)β(3) signaling to Syk kinase in tissue factor-induced thrombin generation
por: van der Meijden, Paola E. J., et al.
Publicado: (2012)

Roles of Focal Adhesion Kinase PTK2 and Integrin αIIbβ3 Signaling in Collagen- and GPVI-Dependent Thrombus Formation under Shear
por: Huang, Jingnan, et al.
Publicado: (2022)

Synthesis and application of cNGR-containing imaging agents for detection of angiogenesis
por: Dijkgraaf, Ingrid, et al.
Publicado: (2013)

Skelemin in Integrin α(IIb)β(3) Mediated Cell Spreading
por: Li, Xinlei, et al.
Publicado: (2012)

The role of neuraminidase 1 and 2 in glycoprotein Ibα-mediated integrin αIIbβ3 activation
por: van der Wal, Dianne E., et al.
Publicado: (2020)

The Integrin-Linked Kinase-PINCH-Parvin Complex Supports Integrin αIIbβ3 Activation
por: Honda, Shigenori, et al.
Publicado: (2013)

Kindlins, Integrin Activation and the Regulation of Talin Recruitment to αIIbβ3
por: Kahner, Bryan N., et al.
Publicado: (2012)

Integrin αIIb-Mediated PI3K/Akt Activation in Platelets
por: Niu, Haixia, et al.
Publicado: (2012)

Skelemin Association with α(IIb)β(3) Integrin: A Structural Model
por: Gorbatyuk, Vitaliy, et al.
Publicado: (2014)

Platelets drive fibronectin fibrillogenesis using integrin αIIbβ3
por: Lickert, Sebastian, et al.
Publicado: (2022)

Reversible Platelet Integrin αIIbβ3 Activation and Thrombus Instability
por: Zou, Jinmi, et al.
Publicado: (2022)

Structure, signal transduction, activation, and inhibition of integrin αIIbβ3
por: Xin, Honglei, et al.
Publicado: (2023)

Structural Basis for the Activation of Platelet Integrin αIIbβ3 by Calcium- and Integrin-Binding Protein 1
por: Huang, Hao, et al.
Publicado: (2012)

Apolipoprotein A-IV binds αIIbβ3 integrin and inhibits thrombosis
por: Xu, Xiaohong Ruby, et al.
Publicado: (2018)

New insights into regulation of αIIbβ3 integrin signaling by filamin A
por: Lamrani, Lamia, et al.
Publicado: (2022)

Clot Retraction and Its Correlation with the Function of Platelet Integrin α(IIb)β(3) †
por: Gao, Daniel, et al.
Publicado: (2023)

Integrin-dependent Control of Translation: Engagement of Integrin α(IIb)β(3) Regulates Synthesis of Proteins in Activated Human Platelets
por: Pabla, Ravinder, et al.
Publicado: (1999)

Mechanisms and consequences of agonist-induced talin recruitment to platelet integrin αIIbβ3
por: Watanabe, Naohide, et al.
Publicado: (2008)

CIB1 is an endogenous inhibitor of agonist-induced integrin αIIbβ3 activation
por: Yuan, Weiping, et al.
Publicado: (2006)

Activation induced morphological changes and integrin αIIbβ3 activity of living platelets()
por: Posch, Sandra, et al.
Publicado: (2013)

β-Subunit Binding Is Sufficient for Ligands to Open the Integrin α(IIb)β(3) Headpiece
por: Lin, Fu-Yang, et al.
Publicado: (2016)

Platelet Integrin αIIbβ3 Inhibitor Rescues Progression of Apoptosis in Human Platelets
por: Zhu, Jie, et al.
Publicado: (2016)

Platelet integrin αIIbβ3: signal transduction, regulation, and its therapeutic targeting
por: Huang, Jiansong, et al.
Publicado: (2019)

An integrin α(IIb)β(3) intermediate affinity state mediates biomechanical platelet aggregation
por: Chen, Yunfeng, et al.
Publicado: (2019)

Hypoxia impairs agonist-induced integrin α(IIb)β(3) activation and platelet aggregation
por: Kiouptsi, Klytaimnistra, et al.
Publicado: (2017)

Cryo-EM structures of full-length integrin αIIbβ3 in native lipids
por: Adair, Brian D., et al.
Publicado: (2023)

Exogenous Ketone Supplements in Athletic Contexts: Past, Present, and Future
por: Evans, Mark, et al.
Publicado: (2022)

Integrin α(IIb) (CD41) plays a role in the maintenance of hematopoietic stem cell activity in the mouse embryonic aorta
por: Boisset, Jean-Charles, et al.
Publicado: (2013)

Pregnancy-Specific Glycoproteins Bind Integrin αIIbβ3 and Inhibit the Platelet—Fibrinogen Interaction
por: Shanley, Daniel K., et al.
Publicado: (2013)

Morphometric analysis of spread platelets identifies integrin α(IIb)β(3)-specific contractile phenotype
por: Lickert, Sebastian, et al.
Publicado: (2018)

Compression force sensing regulates integrin α(IIb)β(3) adhesive function on diabetic platelets
por: Ju, Lining, et al.
Publicado: (2018)

Effects of the RGD loop and C-terminus of rhodostomin on regulating integrin αIIbβ3 recognition
por: Chang, Yao-Tsung, et al.
Publicado: (2017)

The WASH-complex subunit Strumpellin regulates integrin αIIbβ3 trafficking in murine platelets
por: Schurr, Yvonne, et al.
Publicado: (2023)

Molecular basis of anticoagulant and anticomplement activity of the tick salivary protein Salp14 and its homologs
por: Denisov, Stepan S., et al.
Publicado: (2021)

Coordinate interactions of Csk, Src, and Syk kinases with αIIbβ3 initiate integrin signaling to the cytoskeleton
por: Obergfell, Achim, et al.
Publicado: (2002)

Structural basis for distinctive recognition of fibrinogen γC peptide by the platelet integrin α(IIb)β(3)
por: Springer, Timothy A., et al.
Publicado: (2008)

Complementary Roles for Receptor Clustering and Conformational Change in the Adhesive and Signaling Functions of Integrin α(IIb)β(3)
por: Hato, Takaaki, et al.
Publicado: (1998)

The Structure of the N-Terminus of Kindlin-1: A Domain Important for αIIbβ3 Integrin Activation
por: Goult, Benjamin T., et al.
Publicado: (2009)

Human platelet activation by Escherichia coli: roles for FcγRIIA and integrin αIIbβ3
por: Watson, Callum N., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_ocg7b2offvv6pa53o3leldu51a