NF2 and Canonical Hippo-YAP Pathway Define Distinct Tumor Subsets Characterized by Different Immune Deficiency and Treatment Implications in Human Pleural Mesothelioma

SIMPLE SUMMARY: It is a long-held notion that loss-of-function mutations in negative regulators of the Hippo-YAP pathway, such as NF2, LATS1/2, have a similar potential to promote nuclear YAP activity, which is thought to play an essential role in the pathogenesis of MPM. Whether loss-of-function in...

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Detalles Bibliográficos
Autores principales: Yang, Haitang, Hall, Sean R. R., Sun, Beibei, Zhao, Liang, Gao, Yanyun, Schmid, Ralph A., Tan, Swee T., Peng, Ren-Wang, Yao, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8036327/
https://www.ncbi.nlm.nih.gov/pubmed/33805359
http://dx.doi.org/10.3390/cancers13071561

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