Cargando…

Therapeutic miR-21 Silencing Reduces Cardiac Fibrosis and Modulates Inflammatory Response in Chronic Chagas Disease

Chagas disease, caused by the parasite Trypanosoma cruzi (T. cruzi), remains a serious public health problem for which there is no effective treatment in the chronic stage. Intense cardiac fibrosis and inflammation are hallmarks of chronic Chagas disease cardiomyopathy (CCC). Previously, we identifi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nonaka, Carolina Kymie Vasques, Sampaio, Gabriela Louise, de Aragão França, Luciana, Cavalcante, Bruno Raphael, Silva, Katia Nunes, Khouri, Ricardo, Torres, Felipe Guimarães, Meira, Cassio Santana, de Souza Santos, Emanuelle, Macedo, Carolina Thé, Paredes, Bruno Diaz, Rocha, Vinicius Pinto Costa, Rogatto, Silvia Regina, Ribeiro dos Santos, Ricardo, Souza, Bruno Solano de Freitas, Soares, Milena Botelho Pereira
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8036348/ https://www.ncbi.nlm.nih.gov/pubmed/33804922 http://dx.doi.org/10.3390/ijms22073307

Ejemplares similares

Tolerogenic Dendritic Cells Reduce Cardiac Inflammation and Fibrosis in Chronic Chagas Disease
por: Santos, Emanuelle de Souza, et al.
Publicado: (2020)

Circulating miRNAs as Potential Biomarkers Associated with Cardiac Remodeling and Fibrosis in Chagas Disease Cardiomyopathy
por: Nonaka, Carolina Kymie Vasques, et al.
Publicado: (2019)

Therapeutic effects of sphingosine kinase inhibitor N,N-dimethylsphingosine (DMS) in experimental chronic Chagas disease cardiomyopathy
por: Vasconcelos, Juliana Fraga, et al.
Publicado: (2017)

Galectin-3 Knockdown Impairs Survival, Migration, and Immunomodulatory Actions of Mesenchymal Stromal Cells in a Mouse Model of Chagas Disease Cardiomyopathy
por: Souza, Bruno Solano de Freitas, et al.
Publicado: (2017)

Rapid Detection of SARS-CoV-2 Based on the LAMP Assay Associated with the CRISPRCas12a System
por: de Sousa, Karoline Almeida Felix, et al.
Publicado: (2023)

Modulation of MicroRNAs as a Potential Molecular Mechanism Involved in the Beneficial Actions of Physical Exercise in Alzheimer Disease
por: Improta-Caria, Alex Cleber, et al.
Publicado: (2020)

Advances in Hepatic Tissue Bioengineering with Decellularized Liver Bioscaffold
por: Rossi, Erik Aranha, et al.
Publicado: (2019)

Is there a place for mesenchymal stromal cell-based therapies in the therapeutic armamentarium against COVID-19?
por: da Silva, Kátia Nunes, et al.
Publicado: (2021)

Betulinic Acid Derivative BA5, Attenuates Inflammation and Fibrosis in Experimental Chronic Chagas Disease Cardiomyopathy by Inducing IL-10 and M2 Polarization
por: Meira, Cássio Santana, et al.
Publicado: (2019)

Exercise Training-Induced Changes in MicroRNAs: Beneficial Regulatory Effects in Hypertension, Type 2 Diabetes, and Obesity
por: Improta Caria, Alex Cleber, et al.
Publicado: (2018)

Immunomodulation for the Treatment of Chronic Chagas Disease Cardiomyopathy: A New Approach to an Old Enemy
por: Santos, Emanuelle de Souza, et al.
Publicado: (2021)

A Novel High-Content Screening-Based Method for Anti-Trypanosoma cruzi Drug Discovery Using Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes
por: Portella, Diogo Crispim Nascimento, et al.
Publicado: (2021)

Assessment of Galectin-3 Polymorphism in Subjects with Chronic Chagas Disease
por: Cruz, Gabriela da Silva, et al.
Publicado: (2015)

IGF-1-Overexpressing Mesenchymal Stem/Stromal Cells Promote Immunomodulatory and Proregenerative Effects in Chronic Experimental Chagas Disease
por: Silva, Daniela N., et al.
Publicado: (2018)

Assessment of speckle tracking strain predictive value for myocardial fibrosis in subjects with Chagas disease
por: Macedo, Carolina Thé, et al.
Publicado: (2015)

Immunomodulatory and Anti-fibrotic Effects Following the Infusion of Umbilical Cord Mesenchymal Stromal Cells in a Critically Ill Patient With COVID-19 Presenting Lung Fibrosis: A Case Report
por: da Silva, Kátia Nunes, et al.
Publicado: (2021)

Evaluation of urine SARS-COV-2 RT-PCR as a predictor of acute kidney injury and disease severity in patients with critical COVID-19
por: de Souza, Sérgio Pinto, et al.
Publicado: (2021)

SARS-CoV-2 Detection via RT-PCR in Matched Saliva and Nasopharyngeal Samples Reveals High Concordance in Different Commercial Assays
por: de Sousa, Karoline Almeida Felix, et al.
Publicado: (2023)

The Presence and Extension of Myocardial Fibrosis in the Undetermined Form of Chagas’ Disease: A Study Using Magnetic Resonance
por: Noya-Rabelo, Marcia Maria, et al.
Publicado: (2018)

Intramyocardial transplantation of cardiac mesenchymal stem cells reduces myocarditis in a model of chronic Chagas disease cardiomyopathy
por: Silva, Daniela Nascimento, et al.
Publicado: (2014)

Evaluation of 2D and 3D Erythroid Differentiation Protocols Using Sickle Cell Disease and Healthy Donor Induced Pluripotent Stem Cells
por: Martins, Gabriele Louise Soares, et al.
Publicado: (2023)

Lack of association between serum syndecan-4, myocardial fibrosis and ventricular dysfunction in subjects with chronic Chagas disease
por: Larocca, Ticiana Ferreira, et al.
Publicado: (2017)

Early detection of P.1 variant of SARS-CoV-2 in a cluster of cases in Salvador, Brazil
por: de Siqueira, Isadora Cristina, et al.
Publicado: (2021)

Bone marrow-derived mesenchymal stem/stromal cells reverse the sensorial diabetic neuropathy via modulation of spinal neuroinflammatory cascades
por: Evangelista, Afrânio Ferreira, et al.
Publicado: (2018)

Granulocyte-Colony Stimulating Factor-Overexpressing Mesenchymal Stem Cells Exhibit Enhanced Immunomodulatory Actions Through the Recruitment of Suppressor Cells in Experimental Chagas Disease Cardiomyopathy
por: Silva, Daniela N., et al.
Publicado: (2018)

Cytogenomic Investigation of Syndromic Brazilian Patients with Differences of Sexual Development
por: Faria, José Antonio Diniz, et al.
Publicado: (2023)

Electrophysiological characteristics of Chagas disease
por: Cedraz, Swellen Schuenemann, et al.
Publicado: (2013)

IGF-1 overexpression improves mesenchymal stem cell survival and promotes neurological recovery after spinal cord injury
por: Allahdadi, Kyan James, et al.
Publicado: (2019)

Insights from the use of erythropoietin in experimental Chagas disease
por: de Castro Nobre, Ana Carolina, et al.
Publicado: (2022)

The use of standardized Brazilian green propolis extract (EPP-AF) as an adjunct treatment for hospitalized COVID-19 patients (BeeCovid2): a structured summary of a study protocol for a randomized controlled trial
por: Silveira, Marcelo Augusto Duarte, et al.
Publicado: (2022)

SARS-CoV-2 variant of concern P.1 (Gamma) infection in young and middle-aged patients admitted to the intensive care units of a single hospital in Salvador, Northeast Brazil, February 2021
por: Nonaka, Carolina Kymie Vasques, et al.
Publicado: (2021)

Mesenchymal Stem Cells and Atopic Dermatitis: A Review
por: Daltro, Sérgio Ricardo Teixeira, et al.
Publicado: (2020)

Therapeutic Potential of Natural Products in the Treatment of Schistosomiasis
por: Azevedo, Carine Machado, et al.
Publicado: (2023)

Acute Chagas disease in the state of Pará, Amazon Region: is it increasing?
por: dos Santos, Valéria Regina Cavalcante, et al.
Publicado: (2018)

Betulinic Acid Exerts Cytoprotective Activity on Zika Virus-Infected Neural Progenitor Cells
por: Cavalcante, Bruno R. R., et al.
Publicado: (2020)

Efficacy and Safety of Granulocyte-Colony Stimulating Factor Therapy in Chagas Cardiomyopathy: A Phase II Double-Blind, Randomized, Placebo-Controlled Clinical Trial
por: Macedo, Carolina T., et al.
Publicado: (2022)

Early Double-Negative Thymocyte Export in Trypanosoma cruzi Infection Is Restricted by Sphingosine Receptors and Associated with Human Chagas Disease
por: Lepletier, Ailin, et al.
Publicado: (2014)

Erratum: Tolerogenic Dendritic Cells Reduce Airway Inflammation in a Model of Dust Mite Triggered Allergic Inflammation
por: de Aragão-França, Luciana Souza, et al.
Publicado: (2018)

Standardized Brazilian green propolis extract (EPP-AF®) in COVID-19 outcomes: a randomized double-blind placebo-controlled trial
por: Silveira, Marcelo Augusto Duarte, et al.
Publicado: (2023)

Chagas disease ecoepidemiology and environmental changes in northern Minas Gerais state, Brazil
por: Vianna, Elisa Neves, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_63bn7sv8u88ogl5v2meukoddfl