Selective Activation of CNS and Reference PPARGC1A Promoters Is Associated with Distinct Gene Programs Relevant for Neurodegenerative Diseases

The transcriptional regulator peroxisome proliferator activated receptor gamma coactivator 1A (PGC-1α), encoded by PPARGC1A, has been linked to neurodegenerative diseases. Recently discovered CNS-specific PPARGC1A transcripts are initiated far upstream of the reference promoter, spliced to exon 2 of...

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Detalles Bibliográficos
Autores principales: Kwik, Markus, Hainzl, Stefan, Oppelt, Jan, Tichy, Boris, Koller, Ulrich, Bernardinelli, Emanuele, Steiner, Markus, Zara, Greta, Nofziger, Charity, Weis, Serge, Paulmichl, Markus, Dossena, Silvia, Patsch, Wolfgang, Soyal, Selma M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8036390/
https://www.ncbi.nlm.nih.gov/pubmed/33804860
http://dx.doi.org/10.3390/ijms22073296

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