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Cardioinotropic Effects in Subchronic Intoxication of Rats with Lead and/or Cadmium Oxide Nanoparticles
Subchronic intoxication was induced in outbred male rats by repeated intraperitoneal injections with lead oxide (PbO) and/or cadmium oxide (CdO) nanoparticles (NPs) 3 times a week during 6 weeks for the purpose of examining its effects on the contractile characteristics of isolated right ventricle t...
Autores principales: | , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8036427/ https://www.ncbi.nlm.nih.gov/pubmed/33801669 http://dx.doi.org/10.3390/ijms22073466 |
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author | Klinova, Svetlana V. Katsnelson, Boris A. Minigalieva, Ilzira A. Gerzen, Oksana P. Balakin, Alexander A. Lisin, Ruslan V. Butova, Ksenia A. Nabiev, Salavat R. Lookin, Oleg N. Katsnelson, Leonid B. Privalova, Larisa I. Kuznetsov, Daniil A. Shur, Vladimir Ya. Shishkina, Ekaterina V. Makeev, Oleg H. Valamina, Irene E. Panov, Vladimir G. Sutunkova, Marina P. Nikitina, Larisa V. Protsenko, Yuri L. |
author_facet | Klinova, Svetlana V. Katsnelson, Boris A. Minigalieva, Ilzira A. Gerzen, Oksana P. Balakin, Alexander A. Lisin, Ruslan V. Butova, Ksenia A. Nabiev, Salavat R. Lookin, Oleg N. Katsnelson, Leonid B. Privalova, Larisa I. Kuznetsov, Daniil A. Shur, Vladimir Ya. Shishkina, Ekaterina V. Makeev, Oleg H. Valamina, Irene E. Panov, Vladimir G. Sutunkova, Marina P. Nikitina, Larisa V. Protsenko, Yuri L. |
author_sort | Klinova, Svetlana V. |
collection | PubMed |
description | Subchronic intoxication was induced in outbred male rats by repeated intraperitoneal injections with lead oxide (PbO) and/or cadmium oxide (CdO) nanoparticles (NPs) 3 times a week during 6 weeks for the purpose of examining its effects on the contractile characteristics of isolated right ventricle trabeculae and papillary muscles in isometric and afterload contractions. Isolated and combined intoxication with these NPs was observed to reduce the mechanical work produced by both types of myocardial preparation. Using the in vitro motility assay, we showed that the sliding velocity of regulated thin filaments drops under both isolated and combined intoxication with CdO–NP and PbO–NP. These results correlate with a shift in the expression of myosin heavy chain (MHC) isoforms towards slowly cycling β–MHC. The type of CdO–NP + PbO–NP combined cardiotoxicity depends on the effect of the toxic impact, the extent of this effect, the ratio of toxicant doses, and the degree of stretching of cardiomyocytes and muscle type studied. Some indices of combined Pb–NP and CdO–NP cardiotoxicity and general toxicity (genotoxicity included) became fully or partly normalized if intoxication developed against background administration of a bioprotective complex. |
format | Online Article Text |
id | pubmed-8036427 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-80364272021-04-12 Cardioinotropic Effects in Subchronic Intoxication of Rats with Lead and/or Cadmium Oxide Nanoparticles Klinova, Svetlana V. Katsnelson, Boris A. Minigalieva, Ilzira A. Gerzen, Oksana P. Balakin, Alexander A. Lisin, Ruslan V. Butova, Ksenia A. Nabiev, Salavat R. Lookin, Oleg N. Katsnelson, Leonid B. Privalova, Larisa I. Kuznetsov, Daniil A. Shur, Vladimir Ya. Shishkina, Ekaterina V. Makeev, Oleg H. Valamina, Irene E. Panov, Vladimir G. Sutunkova, Marina P. Nikitina, Larisa V. Protsenko, Yuri L. Int J Mol Sci Article Subchronic intoxication was induced in outbred male rats by repeated intraperitoneal injections with lead oxide (PbO) and/or cadmium oxide (CdO) nanoparticles (NPs) 3 times a week during 6 weeks for the purpose of examining its effects on the contractile characteristics of isolated right ventricle trabeculae and papillary muscles in isometric and afterload contractions. Isolated and combined intoxication with these NPs was observed to reduce the mechanical work produced by both types of myocardial preparation. Using the in vitro motility assay, we showed that the sliding velocity of regulated thin filaments drops under both isolated and combined intoxication with CdO–NP and PbO–NP. These results correlate with a shift in the expression of myosin heavy chain (MHC) isoforms towards slowly cycling β–MHC. The type of CdO–NP + PbO–NP combined cardiotoxicity depends on the effect of the toxic impact, the extent of this effect, the ratio of toxicant doses, and the degree of stretching of cardiomyocytes and muscle type studied. Some indices of combined Pb–NP and CdO–NP cardiotoxicity and general toxicity (genotoxicity included) became fully or partly normalized if intoxication developed against background administration of a bioprotective complex. MDPI 2021-03-27 /pmc/articles/PMC8036427/ /pubmed/33801669 http://dx.doi.org/10.3390/ijms22073466 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ). |
spellingShingle | Article Klinova, Svetlana V. Katsnelson, Boris A. Minigalieva, Ilzira A. Gerzen, Oksana P. Balakin, Alexander A. Lisin, Ruslan V. Butova, Ksenia A. Nabiev, Salavat R. Lookin, Oleg N. Katsnelson, Leonid B. Privalova, Larisa I. Kuznetsov, Daniil A. Shur, Vladimir Ya. Shishkina, Ekaterina V. Makeev, Oleg H. Valamina, Irene E. Panov, Vladimir G. Sutunkova, Marina P. Nikitina, Larisa V. Protsenko, Yuri L. Cardioinotropic Effects in Subchronic Intoxication of Rats with Lead and/or Cadmium Oxide Nanoparticles |
title | Cardioinotropic Effects in Subchronic Intoxication of Rats with Lead and/or Cadmium Oxide Nanoparticles |
title_full | Cardioinotropic Effects in Subchronic Intoxication of Rats with Lead and/or Cadmium Oxide Nanoparticles |
title_fullStr | Cardioinotropic Effects in Subchronic Intoxication of Rats with Lead and/or Cadmium Oxide Nanoparticles |
title_full_unstemmed | Cardioinotropic Effects in Subchronic Intoxication of Rats with Lead and/or Cadmium Oxide Nanoparticles |
title_short | Cardioinotropic Effects in Subchronic Intoxication of Rats with Lead and/or Cadmium Oxide Nanoparticles |
title_sort | cardioinotropic effects in subchronic intoxication of rats with lead and/or cadmium oxide nanoparticles |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8036427/ https://www.ncbi.nlm.nih.gov/pubmed/33801669 http://dx.doi.org/10.3390/ijms22073466 |
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