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Timing of Cervico-Vaginal Cytokine Collection during Pregnancy and Preterm Birth: A Comparative Analysis in the PRINCESA Cohort

Preterm birth (PTB), defined as birth before 37 completed weeks of gestation, is a major cause of infant morbidity and mortality. Inflammation is an important component in the physiopathologic pathway leading to PTB but results from cross-sectional studies on associations between inflammation, as me...

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Autores principales: Buxton, Miatta A., Meraz-Cruz, Noemi, Sanchez, Brisa N., Foxman, Betsy, Castillo-Castrejon, Marisol, O’Neill, Marie S., Vadillo-Ortega, Felipe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8036528/
https://www.ncbi.nlm.nih.gov/pubmed/33810264
http://dx.doi.org/10.3390/ijerph18073436
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author Buxton, Miatta A.
Meraz-Cruz, Noemi
Sanchez, Brisa N.
Foxman, Betsy
Castillo-Castrejon, Marisol
O’Neill, Marie S.
Vadillo-Ortega, Felipe
author_facet Buxton, Miatta A.
Meraz-Cruz, Noemi
Sanchez, Brisa N.
Foxman, Betsy
Castillo-Castrejon, Marisol
O’Neill, Marie S.
Vadillo-Ortega, Felipe
author_sort Buxton, Miatta A.
collection PubMed
description Preterm birth (PTB), defined as birth before 37 completed weeks of gestation, is a major cause of infant morbidity and mortality. Inflammation is an important component in the physiopathologic pathway leading to PTB but results from cross-sectional studies on associations between inflammation, as measured by cytokines, and PTB are inconsistent. Timing of cytokine measurement during pregnancy varies between studies and may contribute to inconsistent findings. We investigated the effects of timing on associations between 16 cervico-vaginal cytokines (Eotaxin, IL-10, IL-12p40, IL-17, IL-1RA, sIL-2rα, IL-1a, IL-1β, IL-2, IL-6, IP-10, MCP-1, MIP-1α, MIP-1β, TNFα, and VEGF) and PTB among 90 women throughout pregnancy. We used logistic regression to compare associations between concentrations of cervico-vaginal cytokines from periods in pregnancy and PTB. Trimester 1 cytokines had the strongest positive associations with PTB; for example, OR = 1.76 (95% confidence interval: 1.28, 2.42) for IL-6. Second and third trimester associations were weaker but largely positive. IL-1α was the only cytokine with a negative association (trimesters 2, 3 and overall pregnancy). Strong first trimester associations between cytokines and PTB suggest that measuring cytokines early in pregnancy may hold promise for early identification of PTB risk. Variations in cytokine measurement during pregnancy may contribute to inconsistencies among studies.
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spelling pubmed-80365282021-04-12 Timing of Cervico-Vaginal Cytokine Collection during Pregnancy and Preterm Birth: A Comparative Analysis in the PRINCESA Cohort Buxton, Miatta A. Meraz-Cruz, Noemi Sanchez, Brisa N. Foxman, Betsy Castillo-Castrejon, Marisol O’Neill, Marie S. Vadillo-Ortega, Felipe Int J Environ Res Public Health Brief Report Preterm birth (PTB), defined as birth before 37 completed weeks of gestation, is a major cause of infant morbidity and mortality. Inflammation is an important component in the physiopathologic pathway leading to PTB but results from cross-sectional studies on associations between inflammation, as measured by cytokines, and PTB are inconsistent. Timing of cytokine measurement during pregnancy varies between studies and may contribute to inconsistent findings. We investigated the effects of timing on associations between 16 cervico-vaginal cytokines (Eotaxin, IL-10, IL-12p40, IL-17, IL-1RA, sIL-2rα, IL-1a, IL-1β, IL-2, IL-6, IP-10, MCP-1, MIP-1α, MIP-1β, TNFα, and VEGF) and PTB among 90 women throughout pregnancy. We used logistic regression to compare associations between concentrations of cervico-vaginal cytokines from periods in pregnancy and PTB. Trimester 1 cytokines had the strongest positive associations with PTB; for example, OR = 1.76 (95% confidence interval: 1.28, 2.42) for IL-6. Second and third trimester associations were weaker but largely positive. IL-1α was the only cytokine with a negative association (trimesters 2, 3 and overall pregnancy). Strong first trimester associations between cytokines and PTB suggest that measuring cytokines early in pregnancy may hold promise for early identification of PTB risk. Variations in cytokine measurement during pregnancy may contribute to inconsistencies among studies. MDPI 2021-03-26 /pmc/articles/PMC8036528/ /pubmed/33810264 http://dx.doi.org/10.3390/ijerph18073436 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Brief Report
Buxton, Miatta A.
Meraz-Cruz, Noemi
Sanchez, Brisa N.
Foxman, Betsy
Castillo-Castrejon, Marisol
O’Neill, Marie S.
Vadillo-Ortega, Felipe
Timing of Cervico-Vaginal Cytokine Collection during Pregnancy and Preterm Birth: A Comparative Analysis in the PRINCESA Cohort
title Timing of Cervico-Vaginal Cytokine Collection during Pregnancy and Preterm Birth: A Comparative Analysis in the PRINCESA Cohort
title_full Timing of Cervico-Vaginal Cytokine Collection during Pregnancy and Preterm Birth: A Comparative Analysis in the PRINCESA Cohort
title_fullStr Timing of Cervico-Vaginal Cytokine Collection during Pregnancy and Preterm Birth: A Comparative Analysis in the PRINCESA Cohort
title_full_unstemmed Timing of Cervico-Vaginal Cytokine Collection during Pregnancy and Preterm Birth: A Comparative Analysis in the PRINCESA Cohort
title_short Timing of Cervico-Vaginal Cytokine Collection during Pregnancy and Preterm Birth: A Comparative Analysis in the PRINCESA Cohort
title_sort timing of cervico-vaginal cytokine collection during pregnancy and preterm birth: a comparative analysis in the princesa cohort
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8036528/
https://www.ncbi.nlm.nih.gov/pubmed/33810264
http://dx.doi.org/10.3390/ijerph18073436
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