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The GRKs Reactome: Role in Cell Biology and Pathology

G protein-coupled receptor kinases (GRKs) are protein kinases that function in concert with arrestins in the regulation of a diverse class of G protein-coupled receptors (GPCRs) signaling. Although GRKs and arrestins are key participants in the regulation of GPCR cascades, the complex regulatory mec...

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Autores principales: Chaudhary, Preeti Kumari, Kim, Soochong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8036551/
https://www.ncbi.nlm.nih.gov/pubmed/33806057
http://dx.doi.org/10.3390/ijms22073375
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author Chaudhary, Preeti Kumari
Kim, Soochong
author_facet Chaudhary, Preeti Kumari
Kim, Soochong
author_sort Chaudhary, Preeti Kumari
collection PubMed
description G protein-coupled receptor kinases (GRKs) are protein kinases that function in concert with arrestins in the regulation of a diverse class of G protein-coupled receptors (GPCRs) signaling. Although GRKs and arrestins are key participants in the regulation of GPCR cascades, the complex regulatory mechanisms of GRK expression, its alternation, and their function are not thoroughly understood. Several studies together with the work from our lab in recent years have revealed the critical role of these kinases in various physiological and pathophysiological processes, including cardiovascular biology, inflammation and immunity, neurodegeneration, thrombosis, and hemostasis. A comprehensive understanding of the mechanisms underlying functional interactions with multiple receptor proteins and how these interactions take part in the development of various pathobiological processes may give rise to novel diagnostic and therapeutic strategies. In this review, we summarize the current research linking the role of GRKs to various aspects of cell biology, pathology, and therapeutics, with a particular focus on thrombosis and hemostasis.
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spelling pubmed-80365512021-04-12 The GRKs Reactome: Role in Cell Biology and Pathology Chaudhary, Preeti Kumari Kim, Soochong Int J Mol Sci Review G protein-coupled receptor kinases (GRKs) are protein kinases that function in concert with arrestins in the regulation of a diverse class of G protein-coupled receptors (GPCRs) signaling. Although GRKs and arrestins are key participants in the regulation of GPCR cascades, the complex regulatory mechanisms of GRK expression, its alternation, and their function are not thoroughly understood. Several studies together with the work from our lab in recent years have revealed the critical role of these kinases in various physiological and pathophysiological processes, including cardiovascular biology, inflammation and immunity, neurodegeneration, thrombosis, and hemostasis. A comprehensive understanding of the mechanisms underlying functional interactions with multiple receptor proteins and how these interactions take part in the development of various pathobiological processes may give rise to novel diagnostic and therapeutic strategies. In this review, we summarize the current research linking the role of GRKs to various aspects of cell biology, pathology, and therapeutics, with a particular focus on thrombosis and hemostasis. MDPI 2021-03-25 /pmc/articles/PMC8036551/ /pubmed/33806057 http://dx.doi.org/10.3390/ijms22073375 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Review
Chaudhary, Preeti Kumari
Kim, Soochong
The GRKs Reactome: Role in Cell Biology and Pathology
title The GRKs Reactome: Role in Cell Biology and Pathology
title_full The GRKs Reactome: Role in Cell Biology and Pathology
title_fullStr The GRKs Reactome: Role in Cell Biology and Pathology
title_full_unstemmed The GRKs Reactome: Role in Cell Biology and Pathology
title_short The GRKs Reactome: Role in Cell Biology and Pathology
title_sort grks reactome: role in cell biology and pathology
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8036551/
https://www.ncbi.nlm.nih.gov/pubmed/33806057
http://dx.doi.org/10.3390/ijms22073375
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