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Influence of ACE Gene I/D Polymorphism on Cardiometabolic Risk, Maximal Fat Oxidation, Cardiorespiratory Fitness, Diet and Physical Activity in Young Adults

There is controversy about the relationship between ACE I/D polymorphism and health. Seventy-four healthy adults (n = 28 women; 22.5 ± 4.2 years) participated in this cross-sectional study aimed at determining the influence of ACE I/D polymorphism, ascertained by polymerase chain reaction, on cardio...

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Autores principales: Montes-de-Oca-García, Adrián, Perez-Bey, Alejandro, Velázquez-Díaz, Daniel, Corral-Pérez, Juan, Opazo-Díaz, Edgardo, Rebollo-Ramos, María, Gómez-Gallego, Félix, Cuenca-García, Magdalena, Casals, Cristina, Ponce-González, Jesús G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8036598/
https://www.ncbi.nlm.nih.gov/pubmed/33810312
http://dx.doi.org/10.3390/ijerph18073443
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author Montes-de-Oca-García, Adrián
Perez-Bey, Alejandro
Velázquez-Díaz, Daniel
Corral-Pérez, Juan
Opazo-Díaz, Edgardo
Rebollo-Ramos, María
Gómez-Gallego, Félix
Cuenca-García, Magdalena
Casals, Cristina
Ponce-González, Jesús G.
author_facet Montes-de-Oca-García, Adrián
Perez-Bey, Alejandro
Velázquez-Díaz, Daniel
Corral-Pérez, Juan
Opazo-Díaz, Edgardo
Rebollo-Ramos, María
Gómez-Gallego, Félix
Cuenca-García, Magdalena
Casals, Cristina
Ponce-González, Jesús G.
author_sort Montes-de-Oca-García, Adrián
collection PubMed
description There is controversy about the relationship between ACE I/D polymorphism and health. Seventy-four healthy adults (n = 28 women; 22.5 ± 4.2 years) participated in this cross-sectional study aimed at determining the influence of ACE I/D polymorphism, ascertained by polymerase chain reaction, on cardiometabolic risk (i.e., waist circumference, body fat, blood pressure (BP), glucose, triglycerides, and inflammatory markers), maximal fat oxidation (MFO), cardiorespiratory fitness (maximal oxygen uptake), physical activity and diet. Our results showed differences by ACE I/D polymorphism in systolic BP (DD: 116.4 ± 11.8 mmHg; ID: 116.7 ± 6.3 mmHg; II: 109.4 ± 12.3 mmHg, p = 0.035) and body fat (DD: 27.3 ± 10.8%; ID: 22.6 ± 9.7%; II: 19.3 ± 7.1%, p = 0.030). Interestingly, a genotype*sex interaction in relativized MFO by lean mass (p = 0.048) was found. The DD polymorphism had higher MFO values than ID/II polymorphisms in men (8.4 ± 3.0 vs. 6.5 ± 2.9 mg/kg/min), while the ID/II polymorphisms showed higher R-MFO values than DD polymorphism in women (6.6 ± 2.3 vs. 7.6 ± 2.6 mg/kg/min). In conclusion, ACE I/D polymorphism is apparently associated with adiposity and BP, where a protective effect can be attributed to the II genotype, but not with cardiorespiratory fitness, diet and physical activity. Moreover, our study highlighted that there is a sexual dimorphism in the influence of ACE I/D gene polymorphism on MFO.
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spelling pubmed-80365982021-04-12 Influence of ACE Gene I/D Polymorphism on Cardiometabolic Risk, Maximal Fat Oxidation, Cardiorespiratory Fitness, Diet and Physical Activity in Young Adults Montes-de-Oca-García, Adrián Perez-Bey, Alejandro Velázquez-Díaz, Daniel Corral-Pérez, Juan Opazo-Díaz, Edgardo Rebollo-Ramos, María Gómez-Gallego, Félix Cuenca-García, Magdalena Casals, Cristina Ponce-González, Jesús G. Int J Environ Res Public Health Article There is controversy about the relationship between ACE I/D polymorphism and health. Seventy-four healthy adults (n = 28 women; 22.5 ± 4.2 years) participated in this cross-sectional study aimed at determining the influence of ACE I/D polymorphism, ascertained by polymerase chain reaction, on cardiometabolic risk (i.e., waist circumference, body fat, blood pressure (BP), glucose, triglycerides, and inflammatory markers), maximal fat oxidation (MFO), cardiorespiratory fitness (maximal oxygen uptake), physical activity and diet. Our results showed differences by ACE I/D polymorphism in systolic BP (DD: 116.4 ± 11.8 mmHg; ID: 116.7 ± 6.3 mmHg; II: 109.4 ± 12.3 mmHg, p = 0.035) and body fat (DD: 27.3 ± 10.8%; ID: 22.6 ± 9.7%; II: 19.3 ± 7.1%, p = 0.030). Interestingly, a genotype*sex interaction in relativized MFO by lean mass (p = 0.048) was found. The DD polymorphism had higher MFO values than ID/II polymorphisms in men (8.4 ± 3.0 vs. 6.5 ± 2.9 mg/kg/min), while the ID/II polymorphisms showed higher R-MFO values than DD polymorphism in women (6.6 ± 2.3 vs. 7.6 ± 2.6 mg/kg/min). In conclusion, ACE I/D polymorphism is apparently associated with adiposity and BP, where a protective effect can be attributed to the II genotype, but not with cardiorespiratory fitness, diet and physical activity. Moreover, our study highlighted that there is a sexual dimorphism in the influence of ACE I/D gene polymorphism on MFO. MDPI 2021-03-26 /pmc/articles/PMC8036598/ /pubmed/33810312 http://dx.doi.org/10.3390/ijerph18073443 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Article
Montes-de-Oca-García, Adrián
Perez-Bey, Alejandro
Velázquez-Díaz, Daniel
Corral-Pérez, Juan
Opazo-Díaz, Edgardo
Rebollo-Ramos, María
Gómez-Gallego, Félix
Cuenca-García, Magdalena
Casals, Cristina
Ponce-González, Jesús G.
Influence of ACE Gene I/D Polymorphism on Cardiometabolic Risk, Maximal Fat Oxidation, Cardiorespiratory Fitness, Diet and Physical Activity in Young Adults
title Influence of ACE Gene I/D Polymorphism on Cardiometabolic Risk, Maximal Fat Oxidation, Cardiorespiratory Fitness, Diet and Physical Activity in Young Adults
title_full Influence of ACE Gene I/D Polymorphism on Cardiometabolic Risk, Maximal Fat Oxidation, Cardiorespiratory Fitness, Diet and Physical Activity in Young Adults
title_fullStr Influence of ACE Gene I/D Polymorphism on Cardiometabolic Risk, Maximal Fat Oxidation, Cardiorespiratory Fitness, Diet and Physical Activity in Young Adults
title_full_unstemmed Influence of ACE Gene I/D Polymorphism on Cardiometabolic Risk, Maximal Fat Oxidation, Cardiorespiratory Fitness, Diet and Physical Activity in Young Adults
title_short Influence of ACE Gene I/D Polymorphism on Cardiometabolic Risk, Maximal Fat Oxidation, Cardiorespiratory Fitness, Diet and Physical Activity in Young Adults
title_sort influence of ace gene i/d polymorphism on cardiometabolic risk, maximal fat oxidation, cardiorespiratory fitness, diet and physical activity in young adults
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8036598/
https://www.ncbi.nlm.nih.gov/pubmed/33810312
http://dx.doi.org/10.3390/ijerph18073443
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