Death Receptor 5 (TNFRSF10B) Is Upregulated and TRAIL Resistance Is Reversed in Hypoxia and Normoxia in Colorectal Cancer Cell Lines after Treatment with Skyrin, the Active Metabolite of Hypericum spp.

SIMPLE SUMMARY: Hypoxic conditions are common in solid tumors and are very often connected with the poor prognosis of cancer patients. The lack of oxygen often causes the failure of therapy due to multiple mechanisms increasing cancer survival. Skyrin (SKR) is a secondary plant metabolite from the g...

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Detalles Bibliográficos
Autores principales: Babinčák, Marián, Jendželovský, Rastislav, Košuth, Ján, Majerník, Martin, Vargová, Jana, Mikulášek, Kamil, Zdráhal, Zbyněk, Fedoročko, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8036732/
https://www.ncbi.nlm.nih.gov/pubmed/33916015
http://dx.doi.org/10.3390/cancers13071646

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8036732/
https://www.ncbi.nlm.nih.gov/pubmed/33916015
http://dx.doi.org/10.3390/cancers13071646

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