Cargando…

Intracellular Redox-Modulated Pathways as Targets for Effective Approaches in the Treatment of Viral Infection

Host-directed therapy using drugs that target cellular pathways required for virus lifecycle or its clearance might represent an effective approach for treating infectious diseases. Changes in redox homeostasis, including intracellular glutathione (GSH) depletion, are one of the key events that favo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fraternale, Alessandra, Zara, Carolina, De Angelis, Marta, Nencioni, Lucia, Palamara, Anna Teresa, Retini, Michele, Di Mambro, Tomas, Magnani, Mauro, Crinelli, Rita
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8036776/ https://www.ncbi.nlm.nih.gov/pubmed/33808471 http://dx.doi.org/10.3390/ijms22073603

Ejemplares similares

Redox-Modulating Agents in the Treatment of Viral Infections
por: Checconi, Paola, et al.
Publicado: (2020)

Boosting GSH Using the Co-Drug Approach: I-152, a Conjugate of N-acetyl-cysteine and β-mercaptoethylamine
por: Crinelli, Rita, et al.
Publicado: (2019)

Targeting SARS‐CoV‐2 by synthetic dual‐acting thiol compounds that inhibit Spike/ACE2 interaction and viral protein production
por: Fraternale, Alessandra, et al.
Publicado: (2022)

Intracellular Redox State as Target for Anti-Influenza Therapy: Are Antioxidants Always Effective?
por: Sgarbanti, Rossella, et al.
Publicado: (2014)

Dithiol Based on l-Cysteine and Cysteamine as a Disulfide-Reducing Agent
por: Bartoccini, Francesca, et al.
Publicado: (2022)

Molecules Altering the Intracellular Thiol Content Modulate NF-kB and STAT-1/IRF-1 Signalling Pathways and IL-12 p40 and IL-27 p28 Production in Murine Macrophages
por: Fraternale, Alessandra, et al.
Publicado: (2013)

Dysregulation of intracellular redox homeostasis by the SARS-CoV-2 ORF6 protein
por: De Angelis, Marta, et al.
Publicado: (2023)

Influenza Virus Down-Modulates G6PD Expression and Activity to Induce Oxidative Stress and Promote Its Replication
por: De Angelis, Marta, et al.
Publicado: (2022)

Activation of NRF2 and ATF4 Signaling by the Pro-Glutathione Molecule I-152, a Co-Drug of N-Acetyl-Cysteine and Cysteamine
por: Crinelli, Rita, et al.
Publicado: (2021)

Validation of a Reversed-Phase High Performance Liquid Chromatography Method for the Simultaneous Analysis of Cysteine and Reduced Glutathione in Mouse Organs
por: Brundu, Serena, et al.
Publicado: (2016)

Glutathione increase by the n‐butanoyl glutathione derivative (GSH‐C4) inhibits viral replication and induces a predominant Th1 immune profile in old mice infected with influenza virus
por: Amatore, Donatella, et al.
Publicado: (2019)

Development and in vitro characterization of a humanized scFv against fungal infections
por: Di Mambro, Tomas, et al.
Publicado: (2022)

Interplay between Hepatitis C Virus and Redox Cell Signaling
por: Ruggieri, Anna, et al.
Publicado: (2013)

The Environmental Pollutant Cadmium Promotes Influenza Virus Replication in MDCK Cells by Altering Their Redox State
por: Checconi, Paola, et al.
Publicado: (2013)

AFM evaluation of a humanized recombinant antibody affecting C. auris cell wall and stability
por: Vanzolini, Tania, et al.
Publicado: (2023)

A new humanized antibody is effective against pathogenic fungi in vitro
por: Di Mambro, Tomas, et al.
Publicado: (2021)

Induction of ubiquitin C (UBC) gene transcription is mediated by HSF1: role of proteotoxic and oxidative stress
por: Bianchi, Marzia, et al.
Publicado: (2018)

Yin Yang 1 Intronic Binding Sequences and Splicing Elicit Intron-Mediated Enhancement of Ubiquitin C Gene Expression
por: Bianchi, Marzia, et al.
Publicado: (2013)

Molecular Dissection of the Human Ubiquitin C Promoter Reveals Heat Shock Element Architectures with Activating and Repressive Functions
por: Crinelli, Rita, et al.
Publicado: (2015)

Counteraction of HCV-Induced Oxidative Stress Concurs to Establish Chronic Infection in Liver Cell Cultures
por: Anticoli, Simona, et al.
Publicado: (2019)

Erratum to “Counteraction of HCV-Induced Oxidative Stress Concurs to Establish Chronic Infection in Liver Cell Cultures”
por: Anticoli, Simona, et al.
Publicado: (2019)

GSH-C4 Acts as Anti-inflammatory Drug in Different Models of Canonical and Cell Autonomous Inflammation Through NFκB Inhibition
por: Limongi, Dolores, et al.
Publicado: (2019)

Corrigendum: GSH-C4 Acts as Anti-inflammatory Drug in Different Models of Canonical and Cell Autonomous Inflammation Through NFκB Inhibition
por: Limongi, Dolores, et al.
Publicado: (2019)

Differential Redox State Contributes to Sex Disparities in the Response to Influenza Virus Infection in Male and Female Mice
por: Celestino, Ignacio, et al.
Publicado: (2018)

Aminomalononitrile inspired prebiotic chemistry as a novel multicomponent tool for the synthesis of imidazole and purine derivatives with anti-influenza A virus activity
por: Bizzarri, Bruno Mattia, et al.
Publicado: (2021)

Red Blood Cell Membrane Processing for Biomedical Applications
por: Rossi, Luigia, et al.
Publicado: (2019)

NRF2 Antioxidant Response and Interferon-Stimulated Genes Are Differentially Expressed in Respiratory-Syncytial-Virus- and Rhinovirus-Infected Hospitalized Children
por: Sorrentino, Leonardo, et al.
Publicado: (2023)

Influenza virus replication in lung epithelial cells depends on redox-sensitive pathways activated by NOX4-derived ROS
por: Amatore, Donatella, et al.
Publicado: (2015)

Antifungal Activity of the Frog Skin Peptide Temporin G and Its Effect on Candida albicans Virulence Factors
por: D’Auria, Felicia Diodata, et al.
Publicado: (2022)

Functionalized 3D scaffolds for engineering the hematopoietic niche
por: Bruschi, Michela, et al.
Publicado: (2022)

A negative feedback mechanism links UBC gene expression to ubiquitin levels by affecting RNA splicing rather than transcription
por: Bianchi, Marzia, et al.
Publicado: (2019)

Multitalented Synthetic Antimicrobial Peptides and Their Antibacterial, Antifungal and Antiviral Mechanisms
por: Vanzolini, Tania, et al.
Publicado: (2022)

The Ubiquitin Gene Expression Pattern and Sensitivity to UBB and UBC Knockdown Differentiate Primary 23132/87 and Metastatic MKN45 Gastric Cancer Cells
por: Scarpa, Emanuele Salvatore, et al.
Publicado: (2020)

Gastric cancer cell types display distinct proteasome/immunoproteasome patterns associated with migration and resistance to proteasome inhibitors
por: Monittola, Francesca, et al.
Publicado: (2023)

The Yin and Yang of Current Antifungal Therapeutic Strategies: How Can We Harness Our Natural Defenses?
por: Di Mambro, Tomas, et al.
Publicado: (2019)

Recurrent Herpes Simplex Virus Type 1 (HSV-1) Infection Modulates Neuronal Aging Marks in In Vitro and In Vivo Models
por: Napoletani, Giorgia, et al.
Publicado: (2021)

Nitrostilbenes: Synthesis and Biological Evaluation as Potential Anti-Influenza Virus Agents
por: De Angelis, Marta, et al.
Publicado: (2022)

Redox Proteomics of the Inflammatory Secretome Identifies a Common Set of Redoxins and Other Glutathionylated Proteins Released in Inflammation, Influenza Virus Infection and Oxidative Stress
por: Checconi, Paola, et al.
Publicado: (2015)

Anti-influenza A virus activity and structure–activity relationship of a series of nitrobenzoxadiazole derivatives
por: Fiorentino, Francesco, et al.
Publicado: (2021)

Humanization of Antibodies using a Statistical Inference Approach
por: Clavero-Álvarez, Alejandro, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_8vqu62iu57pmgdl3p1mo0fommk