Cargando…
Effects of Exercise on the Oral Microbiota and Saliva of Patients with Non-Alcoholic Fatty Liver Disease
Exercise can be hypothesized to play an important role in non-alcoholic fatty liver disease (NAFLD) treatment by changing the oral bacterial flora and in the mechanism underlying periodontal disease. We performed salivary component analysis before and after an exercise regimen, and genome analysis o...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8036855/ https://www.ncbi.nlm.nih.gov/pubmed/33810609 http://dx.doi.org/10.3390/ijerph18073470 |
_version_ | 1783677008009494528 |
---|---|
author | Uchida, Fumihiko Oh, Sechang Shida, Takashi Suzuki, Hideo Yamagata, Kenji Mizokami, Yuji Bukawa, Hiroki Tanaka, Kiyoji Shoda, Junichi |
author_facet | Uchida, Fumihiko Oh, Sechang Shida, Takashi Suzuki, Hideo Yamagata, Kenji Mizokami, Yuji Bukawa, Hiroki Tanaka, Kiyoji Shoda, Junichi |
author_sort | Uchida, Fumihiko |
collection | PubMed |
description | Exercise can be hypothesized to play an important role in non-alcoholic fatty liver disease (NAFLD) treatment by changing the oral bacterial flora and in the mechanism underlying periodontal disease. We performed salivary component analysis before and after an exercise regimen, and genome analysis of the oral bacterial flora to elucidate the underlying mechanism. Obese middle-aged men with NAFLD and periodontal disease were allocated to 12-week exercise (n = 49) or dietary restriction (n = 21) groups. We collected saliva to compare the oral microflora; performed predictive analysis of metagenomic functions; and, measured the salivary immunoglobulin A, cytokine, bacterial lipopolysaccharide (LPS), and lactoferrin concentrations. The exercise group showed improvements in the clinical indices of oral environment. Salivary component analysis revealed significant reductions in LPS, and lactoferrin during the exercise regimen. Diversity analysis of oral bacterial flora revealed higher alpha- and beta-diversity after the exercise regimen. Analysis of the microbial composition revealed that the numbers of Campylobacter (+83.9%), Corynebacterium (+142.3%), Actinomyces (+75.9%), and Lautropia (+172.9%) were significantly higher, and that of Prevotella (−28.3%) was significantly lower. The findings suggest that an exercise regimen improves the oral environment of NAFLD patients by increasing the diversity of the oral microflora and reducing the number of periodontal bacteria that produce LPS and its capability. |
format | Online Article Text |
id | pubmed-8036855 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-80368552021-04-12 Effects of Exercise on the Oral Microbiota and Saliva of Patients with Non-Alcoholic Fatty Liver Disease Uchida, Fumihiko Oh, Sechang Shida, Takashi Suzuki, Hideo Yamagata, Kenji Mizokami, Yuji Bukawa, Hiroki Tanaka, Kiyoji Shoda, Junichi Int J Environ Res Public Health Article Exercise can be hypothesized to play an important role in non-alcoholic fatty liver disease (NAFLD) treatment by changing the oral bacterial flora and in the mechanism underlying periodontal disease. We performed salivary component analysis before and after an exercise regimen, and genome analysis of the oral bacterial flora to elucidate the underlying mechanism. Obese middle-aged men with NAFLD and periodontal disease were allocated to 12-week exercise (n = 49) or dietary restriction (n = 21) groups. We collected saliva to compare the oral microflora; performed predictive analysis of metagenomic functions; and, measured the salivary immunoglobulin A, cytokine, bacterial lipopolysaccharide (LPS), and lactoferrin concentrations. The exercise group showed improvements in the clinical indices of oral environment. Salivary component analysis revealed significant reductions in LPS, and lactoferrin during the exercise regimen. Diversity analysis of oral bacterial flora revealed higher alpha- and beta-diversity after the exercise regimen. Analysis of the microbial composition revealed that the numbers of Campylobacter (+83.9%), Corynebacterium (+142.3%), Actinomyces (+75.9%), and Lautropia (+172.9%) were significantly higher, and that of Prevotella (−28.3%) was significantly lower. The findings suggest that an exercise regimen improves the oral environment of NAFLD patients by increasing the diversity of the oral microflora and reducing the number of periodontal bacteria that produce LPS and its capability. MDPI 2021-03-26 /pmc/articles/PMC8036855/ /pubmed/33810609 http://dx.doi.org/10.3390/ijerph18073470 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ). |
spellingShingle | Article Uchida, Fumihiko Oh, Sechang Shida, Takashi Suzuki, Hideo Yamagata, Kenji Mizokami, Yuji Bukawa, Hiroki Tanaka, Kiyoji Shoda, Junichi Effects of Exercise on the Oral Microbiota and Saliva of Patients with Non-Alcoholic Fatty Liver Disease |
title | Effects of Exercise on the Oral Microbiota and Saliva of Patients with Non-Alcoholic Fatty Liver Disease |
title_full | Effects of Exercise on the Oral Microbiota and Saliva of Patients with Non-Alcoholic Fatty Liver Disease |
title_fullStr | Effects of Exercise on the Oral Microbiota and Saliva of Patients with Non-Alcoholic Fatty Liver Disease |
title_full_unstemmed | Effects of Exercise on the Oral Microbiota and Saliva of Patients with Non-Alcoholic Fatty Liver Disease |
title_short | Effects of Exercise on the Oral Microbiota and Saliva of Patients with Non-Alcoholic Fatty Liver Disease |
title_sort | effects of exercise on the oral microbiota and saliva of patients with non-alcoholic fatty liver disease |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8036855/ https://www.ncbi.nlm.nih.gov/pubmed/33810609 http://dx.doi.org/10.3390/ijerph18073470 |
work_keys_str_mv | AT uchidafumihiko effectsofexerciseontheoralmicrobiotaandsalivaofpatientswithnonalcoholicfattyliverdisease AT ohsechang effectsofexerciseontheoralmicrobiotaandsalivaofpatientswithnonalcoholicfattyliverdisease AT shidatakashi effectsofexerciseontheoralmicrobiotaandsalivaofpatientswithnonalcoholicfattyliverdisease AT suzukihideo effectsofexerciseontheoralmicrobiotaandsalivaofpatientswithnonalcoholicfattyliverdisease AT yamagatakenji effectsofexerciseontheoralmicrobiotaandsalivaofpatientswithnonalcoholicfattyliverdisease AT mizokamiyuji effectsofexerciseontheoralmicrobiotaandsalivaofpatientswithnonalcoholicfattyliverdisease AT bukawahiroki effectsofexerciseontheoralmicrobiotaandsalivaofpatientswithnonalcoholicfattyliverdisease AT tanakakiyoji effectsofexerciseontheoralmicrobiotaandsalivaofpatientswithnonalcoholicfattyliverdisease AT shodajunichi effectsofexerciseontheoralmicrobiotaandsalivaofpatientswithnonalcoholicfattyliverdisease |