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Tracing dsDNA Virus–Host Coevolution through Correlation of Their G-Quadruplex-Forming Sequences
The importance of gene expression regulation in viruses based upon G-quadruplex may point to its potential utilization in therapeutic targeting. Here, we present analyses as to the occurrence of putative G-quadruplex-forming sequences (PQS) in all reference viral dsDNA genomes and evaluate their dep...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8036883/ https://www.ncbi.nlm.nih.gov/pubmed/33810462 http://dx.doi.org/10.3390/ijms22073433 |
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author | Bohálová, Natália Cantara, Alessio Bartas, Martin Kaura, Patrik Šťastný, Jiří Pečinka, Petr Fojta, Miroslav Brázda, Václav |
author_facet | Bohálová, Natália Cantara, Alessio Bartas, Martin Kaura, Patrik Šťastný, Jiří Pečinka, Petr Fojta, Miroslav Brázda, Václav |
author_sort | Bohálová, Natália |
collection | PubMed |
description | The importance of gene expression regulation in viruses based upon G-quadruplex may point to its potential utilization in therapeutic targeting. Here, we present analyses as to the occurrence of putative G-quadruplex-forming sequences (PQS) in all reference viral dsDNA genomes and evaluate their dependence on PQS occurrence in host organisms using the G4Hunter tool. PQS frequencies differ across host taxa without regard to GC content. The overlay of PQS with annotated regions reveals the localization of PQS in specific regions. While abundance in some, such as repeat regions, is shared by all groups, others are unique. There is abundance within introns of Eukaryota-infecting viruses, but depletion of PQS in introns of bacteria-infecting viruses. We reveal a significant positive correlation between PQS frequencies in dsDNA viruses and corresponding hosts from archaea, bacteria, and eukaryotes. A strong relationship between PQS in a virus and its host indicates their close coevolution and evolutionarily reciprocal mimicking of genome organization. |
format | Online Article Text |
id | pubmed-8036883 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-80368832021-04-12 Tracing dsDNA Virus–Host Coevolution through Correlation of Their G-Quadruplex-Forming Sequences Bohálová, Natália Cantara, Alessio Bartas, Martin Kaura, Patrik Šťastný, Jiří Pečinka, Petr Fojta, Miroslav Brázda, Václav Int J Mol Sci Article The importance of gene expression regulation in viruses based upon G-quadruplex may point to its potential utilization in therapeutic targeting. Here, we present analyses as to the occurrence of putative G-quadruplex-forming sequences (PQS) in all reference viral dsDNA genomes and evaluate their dependence on PQS occurrence in host organisms using the G4Hunter tool. PQS frequencies differ across host taxa without regard to GC content. The overlay of PQS with annotated regions reveals the localization of PQS in specific regions. While abundance in some, such as repeat regions, is shared by all groups, others are unique. There is abundance within introns of Eukaryota-infecting viruses, but depletion of PQS in introns of bacteria-infecting viruses. We reveal a significant positive correlation between PQS frequencies in dsDNA viruses and corresponding hosts from archaea, bacteria, and eukaryotes. A strong relationship between PQS in a virus and its host indicates their close coevolution and evolutionarily reciprocal mimicking of genome organization. MDPI 2021-03-26 /pmc/articles/PMC8036883/ /pubmed/33810462 http://dx.doi.org/10.3390/ijms22073433 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ). |
spellingShingle | Article Bohálová, Natália Cantara, Alessio Bartas, Martin Kaura, Patrik Šťastný, Jiří Pečinka, Petr Fojta, Miroslav Brázda, Václav Tracing dsDNA Virus–Host Coevolution through Correlation of Their G-Quadruplex-Forming Sequences |
title | Tracing dsDNA Virus–Host Coevolution through Correlation of Their G-Quadruplex-Forming Sequences |
title_full | Tracing dsDNA Virus–Host Coevolution through Correlation of Their G-Quadruplex-Forming Sequences |
title_fullStr | Tracing dsDNA Virus–Host Coevolution through Correlation of Their G-Quadruplex-Forming Sequences |
title_full_unstemmed | Tracing dsDNA Virus–Host Coevolution through Correlation of Their G-Quadruplex-Forming Sequences |
title_short | Tracing dsDNA Virus–Host Coevolution through Correlation of Their G-Quadruplex-Forming Sequences |
title_sort | tracing dsdna virus–host coevolution through correlation of their g-quadruplex-forming sequences |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8036883/ https://www.ncbi.nlm.nih.gov/pubmed/33810462 http://dx.doi.org/10.3390/ijms22073433 |
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