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The Long-Term Follow-Up of Patients with Cystine Stones: A Single-Center Experience for 13 Years

Introduction: Cystine stone development is relatively uncommon among patients with urolithiasis, and most studies have reported only on small sample sizes and short follow-up periods. We evaluated clinical courses and treatment outcomes of patients with cystine stones with long-term follow-up at our...

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Autores principales: Takahashi, Toshifumi, Somiya, Shinya, Ito, Katsuhiro, Kanno, Toru, Higashi, Yoshihito, Yamada, Hitoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037008/
https://www.ncbi.nlm.nih.gov/pubmed/33804827
http://dx.doi.org/10.3390/jcm10071336
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author Takahashi, Toshifumi
Somiya, Shinya
Ito, Katsuhiro
Kanno, Toru
Higashi, Yoshihito
Yamada, Hitoshi
author_facet Takahashi, Toshifumi
Somiya, Shinya
Ito, Katsuhiro
Kanno, Toru
Higashi, Yoshihito
Yamada, Hitoshi
author_sort Takahashi, Toshifumi
collection PubMed
description Introduction: Cystine stone development is relatively uncommon among patients with urolithiasis, and most studies have reported only on small sample sizes and short follow-up periods. We evaluated clinical courses and treatment outcomes of patients with cystine stones with long-term follow-up at our center. Methods: We retrospectively analyzed 22 patients diagnosed with cystine stones between January 1989 and May 2019. Results: The median follow-up was 160 (range 6–340) months, and the median patient age at diagnosis was 46 (range 12–82) years. All patients underwent surgical interventions at the first visit (4 extracorporeal shockwave lithotripsy, 5 ureteroscopy, and 13 percutaneous nephrolithotripsy). The median number of stone events and surgical interventions per year was 0.45 (range 0–2.6) and 0.19 (range 0–1.3) after initial surgical intervention. The median time to stone events and surgical intervention was 2 years and 3.25 years, respectively. There was a significant difference in time to stone events and second surgical intervention when patients were divided at 50 years of age at diagnosis (p = 0.02, 0.04, respectively). Conclusions: Only age at a diagnosis under 50 was significantly associated with recurrent stone events and intervention. Adequate follow-up and treatment are needed to manage patients with cystine stones safely.
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spelling pubmed-80370082021-04-12 The Long-Term Follow-Up of Patients with Cystine Stones: A Single-Center Experience for 13 Years Takahashi, Toshifumi Somiya, Shinya Ito, Katsuhiro Kanno, Toru Higashi, Yoshihito Yamada, Hitoshi J Clin Med Article Introduction: Cystine stone development is relatively uncommon among patients with urolithiasis, and most studies have reported only on small sample sizes and short follow-up periods. We evaluated clinical courses and treatment outcomes of patients with cystine stones with long-term follow-up at our center. Methods: We retrospectively analyzed 22 patients diagnosed with cystine stones between January 1989 and May 2019. Results: The median follow-up was 160 (range 6–340) months, and the median patient age at diagnosis was 46 (range 12–82) years. All patients underwent surgical interventions at the first visit (4 extracorporeal shockwave lithotripsy, 5 ureteroscopy, and 13 percutaneous nephrolithotripsy). The median number of stone events and surgical interventions per year was 0.45 (range 0–2.6) and 0.19 (range 0–1.3) after initial surgical intervention. The median time to stone events and surgical intervention was 2 years and 3.25 years, respectively. There was a significant difference in time to stone events and second surgical intervention when patients were divided at 50 years of age at diagnosis (p = 0.02, 0.04, respectively). Conclusions: Only age at a diagnosis under 50 was significantly associated with recurrent stone events and intervention. Adequate follow-up and treatment are needed to manage patients with cystine stones safely. MDPI 2021-03-24 /pmc/articles/PMC8037008/ /pubmed/33804827 http://dx.doi.org/10.3390/jcm10071336 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Article
Takahashi, Toshifumi
Somiya, Shinya
Ito, Katsuhiro
Kanno, Toru
Higashi, Yoshihito
Yamada, Hitoshi
The Long-Term Follow-Up of Patients with Cystine Stones: A Single-Center Experience for 13 Years
title The Long-Term Follow-Up of Patients with Cystine Stones: A Single-Center Experience for 13 Years
title_full The Long-Term Follow-Up of Patients with Cystine Stones: A Single-Center Experience for 13 Years
title_fullStr The Long-Term Follow-Up of Patients with Cystine Stones: A Single-Center Experience for 13 Years
title_full_unstemmed The Long-Term Follow-Up of Patients with Cystine Stones: A Single-Center Experience for 13 Years
title_short The Long-Term Follow-Up of Patients with Cystine Stones: A Single-Center Experience for 13 Years
title_sort long-term follow-up of patients with cystine stones: a single-center experience for 13 years
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037008/
https://www.ncbi.nlm.nih.gov/pubmed/33804827
http://dx.doi.org/10.3390/jcm10071336
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