Cargando…

Synthesis and Rational Design of New Appended 1,2,3-Triazole-uracil Ensembles as Promising Anti-Tumor Agents via In Silico VEGFR-2 Transferase Inhibition

Angiogenesis inhibition is a key step towards the designing of new chemotherapeutic agents. In a view to preparing new molecular entities for cancer treatment, eighteen 1,2,3-triazole-uracil ensembles 5a–r were designed and synthesized via the click reaction. The ligands were well characterized usin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Reddy, Nadipolla Naresh, Hung, Sung-Jen, Swamy, Merugu Kumara, Sanjeev, Ananthula, Rao, Vankadari Srinivasa, Rohini, Rondla, Raju, Atcha Krishnam, Bhaskar, Kuthati, Hu, Anren, Reddy, Puchakayala Muralidhar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037033/ https://www.ncbi.nlm.nih.gov/pubmed/33808444 http://dx.doi.org/10.3390/molecules26071952

Ejemplares similares

Synthesis, Spectral and Antibacterial Studies of Copper(II) Tetraaza Macrocyclic Complexes
por: Reddy, Puchakayala Muralidhar, et al.
Publicado: (2012)

Molecular Design, Synthesis, and Biological Evaluation of 2-Hydroxy-3-Chrysino Dithiocarbamate Derivatives
por: Ramesh, Pulabala, et al.
Publicado: (2019)

In Situ FTIR Spectroscopic Monitoring of the Formation of the Arene Diazonium Salts and Its Applications to the Heck–Matsuda Reaction
por: Reddy, K. Sateesh, et al.
Publicado: (2020)

Synthesis of New 1,2,3-Triazole Derivatives of Uracil and Thymine with Potential Inhibitory Activity against Acidic Corrosion of Steels
por: Negrón-Silva, Guillermo E., et al.
Publicado: (2013)

Structure of the uracil complex of Vaccinia virus uracil DNA glycosylase
por: Schormann, N., et al.
Publicado: (2013)

A structural determinant in the uracil DNA glycosylase superfamily for the removal of uracil from adenine/uracil base pairs
por: Lee, Dong-Hoon, et al.
Publicado: (2015)

A unique uracil-DNA binding protein of the uracil DNA glycosylase superfamily
por: Sang, Pau Biak, et al.
Publicado: (2015)

Molecular docking analysis of C-phycocyanin with VEGFR2
por: Bannu, Saira M, et al.
Publicado: (2020)

1,2,3-Triazoles
por: Rachwal, S., et al.
Publicado: (2008)

Molecular docking and simulation of Curcumin with Geranylgeranyl Transferase1 (GGTase1) and Farnesyl Transferase (FTase)
por: Subramani, Parasuraman Aiya, et al.
Publicado: (2015)

One-pot three component synthesis of 5-allyl-1,2,3-triazoles using copper(i) acetylides
por: Reddy, Parigi Raghavendar, et al.
Publicado: (2018)

Allenylphosphine oxides as simple scaffolds for phosphinoylindoles and phosphinoylisocoumarins
por: Gangadhararao, G, et al.
Publicado: (2014)

Redetermination of 5-iodouracil
por: Portalone, Gustavo
Publicado: (2008)

Redetermination of 3-deazauracil
por: Portalone, Gustavo
Publicado: (2008)

Detection of Genomic Uracil Patterns
por: Békési, Angéla, et al.
Publicado: (2021)

Novel 1,2,3-Triazole-Coumarin Hybrid Glycosides and Their Tetrazolyl Analogues: Design, Anticancer Evaluation and Molecular Docking Targeting EGFR, VEGFR-2 and CDK-2
por: El-Sayed, Wael A., et al.
Publicado: (2022)

Correction to 14,15-Epoxyeicosa-5,8,11-trienoic Acid (14,15-EET) Surrogates: Carboxylate Modifications
por: Falck, John R., et al.
Publicado: (2014)

The First 5′-Phosphorylated 1,2,3-Triazolyl Nucleoside Analogues with Uracil and Quinazoline-2,4-Dione Moieties: A Synthesis and Antiviral Evaluation
por: Tatarinov, Dmitry A., et al.
Publicado: (2022)

Crystal structure of 4,5-bis(3,4,5-trimethoxyphenyl)-2H-1,2,3-triazole methanol monosolvate
por: Madadi, Nikhil Reddy, et al.
Publicado: (2014)

3-Benzoyl-5-chlorouracil
por: Gainsford, Graeme J., et al.
Publicado: (2009)

Photoprotecting Uracil by Coupling with Lossy Nanocavities
por: Felicetti, Simone, et al.
Publicado: (2020)

Uracil Derivatives for Halogen-Bonded Cocrystals
por: Benito, Mónica, et al.
Publicado: (2021)

Intramolecular Interactions in Derivatives of Uracil Tautomers
por: Wieczorkiewicz, Paweł A., et al.
Publicado: (2022)

Uracil in the carbonaceous asteroid (162173) Ryugu
por: Oba, Yasuhiro, et al.
Publicado: (2023)

Comparison of crystal structures of 4-(benzo[b]thiophen-2-yl)-5-(3,4,5-trimethoxyphenyl)-2H-1,2,3-triazole and 4-(benzo[b]thiophen-2-yl)-2-methyl-5-(3,4,5-trimethoxyphenyl)-2H-1,2,3-triazole
por: Penthala, Narsimha Reddy, et al.
Publicado: (2014)

Efficient Green Synthesis, Anticancer Activity, and Molecular Docking Studies of Indolemethanes Using a Bioglycerol-Based Carbon Sulfonic Acid Catalyst
por: Gogula, Sailam Sri, et al.
Publicado: (2023)

Glutathione S-transferase is a good biomarker in acrylamide induced neurotoxicity and genotoxicity
por: Dasari, Sreenivasulu, et al.
Publicado: (2018)

Rhodium catalyzed diastereoselective synthesis of 2,2,3,3-tetrasubstituted indolines from N-sulfonyl-1,2,3-triazoles and ortho-vinylanilines
por: Yadagiri, Dongari, et al.
Publicado: (2016)

Microwave-assisted synthesis, biological evaluation and molecular docking studies of new coumarin-based 1,2,3-triazoles
por: Dharavath, Ravinder, et al.
Publicado: (2020)

Removal of uracil by uracil DNA glycosylase limits pemetrexed cytotoxicity: overriding the limit with methoxyamine to inhibit base excision repair
por: Bulgar, A D, et al.
Publicado: (2012)

Uracil–DNA glycosylase UNG1 isoform variant supports class switch recombination and repairs nuclear genomic uracil
por: Sarno, Antonio, et al.
Publicado: (2019)

Uracil as a Zn-Binding Bioisostere of the Allergic Benzenesulfonamide in the Design of Quinoline–Uracil Hybrids as Anticancer Carbonic Anhydrase Inhibitors
por: El-Kalyoubi, Samar A., et al.
Publicado: (2022)

Stereotactic Body Radiotherapy Immunological Planning—A Review With a Proposed Theoretical Model
por: Swamy, Kumara
Publicado: (2022)

Vascular normalization and immunotherapy: Spawning a virtuous cycle
por: Swamy, Kumara
Publicado: (2022)

Design, synthesis, and activity of 2-aminochromone core N,N-bis-1,2,3-triazole derivatives using click chemistry
por: Yerrabelly, Jayaprakash Rao, et al.
Publicado: (2022)

Uracil within DNA: an actor of antiviral immunity
por: Sire, Joséphine, et al.
Publicado: (2008)

Dependence of antibody gene diversification on uracil excision
por: Di Noia, Javier M., et al.
Publicado: (2007)

Mitochondrial inhibition of uracil-DNA glycosylase is not mutagenic
por: Kachhap, Sushant, et al.
Publicado: (2004)

An uracil-linked hydroxyflavone probe for the recognition of ATP
por: Bojtár, Márton, et al.
Publicado: (2018)

Uracil moieties in Plasmodium falciparum genomic DNA
por: Molnár, Petra, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_qfigmujq9tmbqtacjh9jmap3ft