Cargando…
Biocompatibility and Pharmacological Effects of Innovative Systems for Prolonged Drug Release Containing Dexketoprofen in Rats
The present study reports on the in vivo biocompatibility investigation and evaluation of the effects of liposomes containing dexketoprofen in somatic sensitivity in rats. Method: The liposomes were prepared by entrapping dexketoprofen in vesicular systems stabilized with chitosan. The in vivo bioco...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037047/ https://www.ncbi.nlm.nih.gov/pubmed/33805954 http://dx.doi.org/10.3390/polym13071010 |
_version_ | 1783677052363210752 |
---|---|
author | Mititelu-Tartau, Liliana Bogdan, Maria Pricop, Daniela Angelica Buca, Beatrice Rozalina Hilitanu, Loredana Pauna, Ana-Maria Dijmarescu, Lorena Anda Popa, Eliza Gratiela |
author_facet | Mititelu-Tartau, Liliana Bogdan, Maria Pricop, Daniela Angelica Buca, Beatrice Rozalina Hilitanu, Loredana Pauna, Ana-Maria Dijmarescu, Lorena Anda Popa, Eliza Gratiela |
author_sort | Mititelu-Tartau, Liliana |
collection | PubMed |
description | The present study reports on the in vivo biocompatibility investigation and evaluation of the effects of liposomes containing dexketoprofen in somatic sensitivity in rats. Method: The liposomes were prepared by entrapping dexketoprofen in vesicular systems stabilized with chitosan. The in vivo biocompatibility was evaluated after oral administration in white Wistar rats: Group I (DW): distilled water 0.3 mL/100 g body weight; Group II (DEX): dexketoprofen 10 mg/kg body weight (kbw); Group III (nano-DEX): liposomes containing dexketoprofen 10 mg/kbw. Blood samples were collected from caudal lateral vein one day and seven days after the substance administration, to assess the eventual hematological, biochemical, and immunological changes. The investigation of somatic pain reactivity was performed using the hot plate test, to count the latency time response evoked by the thermal paws’ noxious stimulation. Results: Original liposomes entrapping dexketoprofen, with mean size of 680 nm and good stability, were designed. Laboratory analysis indicated no substantial variances between the three treated groups. The treatment with liposomes containing dexketoprofen resulted in a prolongation of the latency time response, statistically significant in the interval between 90 min and 10 h, in the hot plate test. Conclusions: The use of liposomes with dexketoprofen proved a good in vivo biocompatibility in rats and prolonged analgesic effects in the hot plate test. |
format | Online Article Text |
id | pubmed-8037047 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-80370472021-04-12 Biocompatibility and Pharmacological Effects of Innovative Systems for Prolonged Drug Release Containing Dexketoprofen in Rats Mititelu-Tartau, Liliana Bogdan, Maria Pricop, Daniela Angelica Buca, Beatrice Rozalina Hilitanu, Loredana Pauna, Ana-Maria Dijmarescu, Lorena Anda Popa, Eliza Gratiela Polymers (Basel) Article The present study reports on the in vivo biocompatibility investigation and evaluation of the effects of liposomes containing dexketoprofen in somatic sensitivity in rats. Method: The liposomes were prepared by entrapping dexketoprofen in vesicular systems stabilized with chitosan. The in vivo biocompatibility was evaluated after oral administration in white Wistar rats: Group I (DW): distilled water 0.3 mL/100 g body weight; Group II (DEX): dexketoprofen 10 mg/kg body weight (kbw); Group III (nano-DEX): liposomes containing dexketoprofen 10 mg/kbw. Blood samples were collected from caudal lateral vein one day and seven days after the substance administration, to assess the eventual hematological, biochemical, and immunological changes. The investigation of somatic pain reactivity was performed using the hot plate test, to count the latency time response evoked by the thermal paws’ noxious stimulation. Results: Original liposomes entrapping dexketoprofen, with mean size of 680 nm and good stability, were designed. Laboratory analysis indicated no substantial variances between the three treated groups. The treatment with liposomes containing dexketoprofen resulted in a prolongation of the latency time response, statistically significant in the interval between 90 min and 10 h, in the hot plate test. Conclusions: The use of liposomes with dexketoprofen proved a good in vivo biocompatibility in rats and prolonged analgesic effects in the hot plate test. MDPI 2021-03-25 /pmc/articles/PMC8037047/ /pubmed/33805954 http://dx.doi.org/10.3390/polym13071010 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ). |
spellingShingle | Article Mititelu-Tartau, Liliana Bogdan, Maria Pricop, Daniela Angelica Buca, Beatrice Rozalina Hilitanu, Loredana Pauna, Ana-Maria Dijmarescu, Lorena Anda Popa, Eliza Gratiela Biocompatibility and Pharmacological Effects of Innovative Systems for Prolonged Drug Release Containing Dexketoprofen in Rats |
title | Biocompatibility and Pharmacological Effects of Innovative Systems for Prolonged Drug Release Containing Dexketoprofen in Rats |
title_full | Biocompatibility and Pharmacological Effects of Innovative Systems for Prolonged Drug Release Containing Dexketoprofen in Rats |
title_fullStr | Biocompatibility and Pharmacological Effects of Innovative Systems for Prolonged Drug Release Containing Dexketoprofen in Rats |
title_full_unstemmed | Biocompatibility and Pharmacological Effects of Innovative Systems for Prolonged Drug Release Containing Dexketoprofen in Rats |
title_short | Biocompatibility and Pharmacological Effects of Innovative Systems for Prolonged Drug Release Containing Dexketoprofen in Rats |
title_sort | biocompatibility and pharmacological effects of innovative systems for prolonged drug release containing dexketoprofen in rats |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037047/ https://www.ncbi.nlm.nih.gov/pubmed/33805954 http://dx.doi.org/10.3390/polym13071010 |
work_keys_str_mv | AT mititelutartauliliana biocompatibilityandpharmacologicaleffectsofinnovativesystemsforprolongeddrugreleasecontainingdexketoprofeninrats AT bogdanmaria biocompatibilityandpharmacologicaleffectsofinnovativesystemsforprolongeddrugreleasecontainingdexketoprofeninrats AT pricopdanielaangelica biocompatibilityandpharmacologicaleffectsofinnovativesystemsforprolongeddrugreleasecontainingdexketoprofeninrats AT bucabeatricerozalina biocompatibilityandpharmacologicaleffectsofinnovativesystemsforprolongeddrugreleasecontainingdexketoprofeninrats AT hilitanuloredana biocompatibilityandpharmacologicaleffectsofinnovativesystemsforprolongeddrugreleasecontainingdexketoprofeninrats AT paunaanamaria biocompatibilityandpharmacologicaleffectsofinnovativesystemsforprolongeddrugreleasecontainingdexketoprofeninrats AT dijmaresculorenaanda biocompatibilityandpharmacologicaleffectsofinnovativesystemsforprolongeddrugreleasecontainingdexketoprofeninrats AT popaelizagratiela biocompatibilityandpharmacologicaleffectsofinnovativesystemsforprolongeddrugreleasecontainingdexketoprofeninrats |