Cargando…

Biocompatibility and Pharmacological Effects of Innovative Systems for Prolonged Drug Release Containing Dexketoprofen in Rats

The present study reports on the in vivo biocompatibility investigation and evaluation of the effects of liposomes containing dexketoprofen in somatic sensitivity in rats. Method: The liposomes were prepared by entrapping dexketoprofen in vesicular systems stabilized with chitosan. The in vivo bioco...

Descripción completa

Detalles Bibliográficos
Autores principales: Mititelu-Tartau, Liliana, Bogdan, Maria, Pricop, Daniela Angelica, Buca, Beatrice Rozalina, Hilitanu, Loredana, Pauna, Ana-Maria, Dijmarescu, Lorena Anda, Popa, Eliza Gratiela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037047/
https://www.ncbi.nlm.nih.gov/pubmed/33805954
http://dx.doi.org/10.3390/polym13071010
_version_ 1783677052363210752
author Mititelu-Tartau, Liliana
Bogdan, Maria
Pricop, Daniela Angelica
Buca, Beatrice Rozalina
Hilitanu, Loredana
Pauna, Ana-Maria
Dijmarescu, Lorena Anda
Popa, Eliza Gratiela
author_facet Mititelu-Tartau, Liliana
Bogdan, Maria
Pricop, Daniela Angelica
Buca, Beatrice Rozalina
Hilitanu, Loredana
Pauna, Ana-Maria
Dijmarescu, Lorena Anda
Popa, Eliza Gratiela
author_sort Mititelu-Tartau, Liliana
collection PubMed
description The present study reports on the in vivo biocompatibility investigation and evaluation of the effects of liposomes containing dexketoprofen in somatic sensitivity in rats. Method: The liposomes were prepared by entrapping dexketoprofen in vesicular systems stabilized with chitosan. The in vivo biocompatibility was evaluated after oral administration in white Wistar rats: Group I (DW): distilled water 0.3 mL/100 g body weight; Group II (DEX): dexketoprofen 10 mg/kg body weight (kbw); Group III (nano-DEX): liposomes containing dexketoprofen 10 mg/kbw. Blood samples were collected from caudal lateral vein one day and seven days after the substance administration, to assess the eventual hematological, biochemical, and immunological changes. The investigation of somatic pain reactivity was performed using the hot plate test, to count the latency time response evoked by the thermal paws’ noxious stimulation. Results: Original liposomes entrapping dexketoprofen, with mean size of 680 nm and good stability, were designed. Laboratory analysis indicated no substantial variances between the three treated groups. The treatment with liposomes containing dexketoprofen resulted in a prolongation of the latency time response, statistically significant in the interval between 90 min and 10 h, in the hot plate test. Conclusions: The use of liposomes with dexketoprofen proved a good in vivo biocompatibility in rats and prolonged analgesic effects in the hot plate test.
format Online
Article
Text
id pubmed-8037047
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-80370472021-04-12 Biocompatibility and Pharmacological Effects of Innovative Systems for Prolonged Drug Release Containing Dexketoprofen in Rats Mititelu-Tartau, Liliana Bogdan, Maria Pricop, Daniela Angelica Buca, Beatrice Rozalina Hilitanu, Loredana Pauna, Ana-Maria Dijmarescu, Lorena Anda Popa, Eliza Gratiela Polymers (Basel) Article The present study reports on the in vivo biocompatibility investigation and evaluation of the effects of liposomes containing dexketoprofen in somatic sensitivity in rats. Method: The liposomes were prepared by entrapping dexketoprofen in vesicular systems stabilized with chitosan. The in vivo biocompatibility was evaluated after oral administration in white Wistar rats: Group I (DW): distilled water 0.3 mL/100 g body weight; Group II (DEX): dexketoprofen 10 mg/kg body weight (kbw); Group III (nano-DEX): liposomes containing dexketoprofen 10 mg/kbw. Blood samples were collected from caudal lateral vein one day and seven days after the substance administration, to assess the eventual hematological, biochemical, and immunological changes. The investigation of somatic pain reactivity was performed using the hot plate test, to count the latency time response evoked by the thermal paws’ noxious stimulation. Results: Original liposomes entrapping dexketoprofen, with mean size of 680 nm and good stability, were designed. Laboratory analysis indicated no substantial variances between the three treated groups. The treatment with liposomes containing dexketoprofen resulted in a prolongation of the latency time response, statistically significant in the interval between 90 min and 10 h, in the hot plate test. Conclusions: The use of liposomes with dexketoprofen proved a good in vivo biocompatibility in rats and prolonged analgesic effects in the hot plate test. MDPI 2021-03-25 /pmc/articles/PMC8037047/ /pubmed/33805954 http://dx.doi.org/10.3390/polym13071010 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Article
Mititelu-Tartau, Liliana
Bogdan, Maria
Pricop, Daniela Angelica
Buca, Beatrice Rozalina
Hilitanu, Loredana
Pauna, Ana-Maria
Dijmarescu, Lorena Anda
Popa, Eliza Gratiela
Biocompatibility and Pharmacological Effects of Innovative Systems for Prolonged Drug Release Containing Dexketoprofen in Rats
title Biocompatibility and Pharmacological Effects of Innovative Systems for Prolonged Drug Release Containing Dexketoprofen in Rats
title_full Biocompatibility and Pharmacological Effects of Innovative Systems for Prolonged Drug Release Containing Dexketoprofen in Rats
title_fullStr Biocompatibility and Pharmacological Effects of Innovative Systems for Prolonged Drug Release Containing Dexketoprofen in Rats
title_full_unstemmed Biocompatibility and Pharmacological Effects of Innovative Systems for Prolonged Drug Release Containing Dexketoprofen in Rats
title_short Biocompatibility and Pharmacological Effects of Innovative Systems for Prolonged Drug Release Containing Dexketoprofen in Rats
title_sort biocompatibility and pharmacological effects of innovative systems for prolonged drug release containing dexketoprofen in rats
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037047/
https://www.ncbi.nlm.nih.gov/pubmed/33805954
http://dx.doi.org/10.3390/polym13071010
work_keys_str_mv AT mititelutartauliliana biocompatibilityandpharmacologicaleffectsofinnovativesystemsforprolongeddrugreleasecontainingdexketoprofeninrats
AT bogdanmaria biocompatibilityandpharmacologicaleffectsofinnovativesystemsforprolongeddrugreleasecontainingdexketoprofeninrats
AT pricopdanielaangelica biocompatibilityandpharmacologicaleffectsofinnovativesystemsforprolongeddrugreleasecontainingdexketoprofeninrats
AT bucabeatricerozalina biocompatibilityandpharmacologicaleffectsofinnovativesystemsforprolongeddrugreleasecontainingdexketoprofeninrats
AT hilitanuloredana biocompatibilityandpharmacologicaleffectsofinnovativesystemsforprolongeddrugreleasecontainingdexketoprofeninrats
AT paunaanamaria biocompatibilityandpharmacologicaleffectsofinnovativesystemsforprolongeddrugreleasecontainingdexketoprofeninrats
AT dijmaresculorenaanda biocompatibilityandpharmacologicaleffectsofinnovativesystemsforprolongeddrugreleasecontainingdexketoprofeninrats
AT popaelizagratiela biocompatibilityandpharmacologicaleffectsofinnovativesystemsforprolongeddrugreleasecontainingdexketoprofeninrats