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Aurora Kinase B Inhibition: A Potential Therapeutic Strategy for Cancer

Aurora kinase B (AURKB) is a mitotic serine/threonine protein kinase that belongs to the aurora kinase family along with aurora kinase A (AURKA) and aurora kinase C (AURKC). AURKB is a member of the chromosomal passenger protein complex and plays a role in cell cycle progression. Deregulation of AUR...

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Autores principales: Borah, Naheed Arfin, Reddy, Mamatha M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037052/
https://www.ncbi.nlm.nih.gov/pubmed/33915740
http://dx.doi.org/10.3390/molecules26071981
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author Borah, Naheed Arfin
Reddy, Mamatha M.
author_facet Borah, Naheed Arfin
Reddy, Mamatha M.
author_sort Borah, Naheed Arfin
collection PubMed
description Aurora kinase B (AURKB) is a mitotic serine/threonine protein kinase that belongs to the aurora kinase family along with aurora kinase A (AURKA) and aurora kinase C (AURKC). AURKB is a member of the chromosomal passenger protein complex and plays a role in cell cycle progression. Deregulation of AURKB is observed in several tumors and its overexpression is frequently linked to tumor cell invasion, metastasis and drug resistance. AURKB has emerged as an attractive drug target leading to the development of small molecule inhibitors. This review summarizes recent findings pertaining to the role of AURKB in tumor development, therapy related drug resistance, and its inhibition as a potential therapeutic strategy for cancer. We discuss AURKB inhibitors that are in preclinical and clinical development and combination studies of AURKB inhibition with other therapeutic strategies.
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spelling pubmed-80370522021-04-12 Aurora Kinase B Inhibition: A Potential Therapeutic Strategy for Cancer Borah, Naheed Arfin Reddy, Mamatha M. Molecules Review Aurora kinase B (AURKB) is a mitotic serine/threonine protein kinase that belongs to the aurora kinase family along with aurora kinase A (AURKA) and aurora kinase C (AURKC). AURKB is a member of the chromosomal passenger protein complex and plays a role in cell cycle progression. Deregulation of AURKB is observed in several tumors and its overexpression is frequently linked to tumor cell invasion, metastasis and drug resistance. AURKB has emerged as an attractive drug target leading to the development of small molecule inhibitors. This review summarizes recent findings pertaining to the role of AURKB in tumor development, therapy related drug resistance, and its inhibition as a potential therapeutic strategy for cancer. We discuss AURKB inhibitors that are in preclinical and clinical development and combination studies of AURKB inhibition with other therapeutic strategies. MDPI 2021-04-01 /pmc/articles/PMC8037052/ /pubmed/33915740 http://dx.doi.org/10.3390/molecules26071981 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Review
Borah, Naheed Arfin
Reddy, Mamatha M.
Aurora Kinase B Inhibition: A Potential Therapeutic Strategy for Cancer
title Aurora Kinase B Inhibition: A Potential Therapeutic Strategy for Cancer
title_full Aurora Kinase B Inhibition: A Potential Therapeutic Strategy for Cancer
title_fullStr Aurora Kinase B Inhibition: A Potential Therapeutic Strategy for Cancer
title_full_unstemmed Aurora Kinase B Inhibition: A Potential Therapeutic Strategy for Cancer
title_short Aurora Kinase B Inhibition: A Potential Therapeutic Strategy for Cancer
title_sort aurora kinase b inhibition: a potential therapeutic strategy for cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037052/
https://www.ncbi.nlm.nih.gov/pubmed/33915740
http://dx.doi.org/10.3390/molecules26071981
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