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Long Noncoding RNAs—Crucial Players Organizing the Landscape of the Neuronal Nucleus

The ability to regulate chromatin organization is particularly important in neurons, which dynamically respond to external stimuli. Accumulating evidence shows that lncRNAs play important architectural roles in organizing different nuclear domains like inactive chromosome X, splicing speckles, paras...

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Detalles Bibliográficos
Autores principales: Sas-Nowosielska, Hanna, Magalska, Adriana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037058/
https://www.ncbi.nlm.nih.gov/pubmed/33801737
http://dx.doi.org/10.3390/ijms22073478
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author Sas-Nowosielska, Hanna
Magalska, Adriana
author_facet Sas-Nowosielska, Hanna
Magalska, Adriana
author_sort Sas-Nowosielska, Hanna
collection PubMed
description The ability to regulate chromatin organization is particularly important in neurons, which dynamically respond to external stimuli. Accumulating evidence shows that lncRNAs play important architectural roles in organizing different nuclear domains like inactive chromosome X, splicing speckles, paraspeckles, and Gomafu nuclear bodies. LncRNAs are abundantly expressed in the nervous system where they may play important roles in compartmentalization of the cell nucleus. In this review we will describe the architectural role of lncRNAs in the nuclei of neuronal cells.
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spelling pubmed-80370582021-04-12 Long Noncoding RNAs—Crucial Players Organizing the Landscape of the Neuronal Nucleus Sas-Nowosielska, Hanna Magalska, Adriana Int J Mol Sci Review The ability to regulate chromatin organization is particularly important in neurons, which dynamically respond to external stimuli. Accumulating evidence shows that lncRNAs play important architectural roles in organizing different nuclear domains like inactive chromosome X, splicing speckles, paraspeckles, and Gomafu nuclear bodies. LncRNAs are abundantly expressed in the nervous system where they may play important roles in compartmentalization of the cell nucleus. In this review we will describe the architectural role of lncRNAs in the nuclei of neuronal cells. MDPI 2021-03-27 /pmc/articles/PMC8037058/ /pubmed/33801737 http://dx.doi.org/10.3390/ijms22073478 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Review
Sas-Nowosielska, Hanna
Magalska, Adriana
Long Noncoding RNAs—Crucial Players Organizing the Landscape of the Neuronal Nucleus
title Long Noncoding RNAs—Crucial Players Organizing the Landscape of the Neuronal Nucleus
title_full Long Noncoding RNAs—Crucial Players Organizing the Landscape of the Neuronal Nucleus
title_fullStr Long Noncoding RNAs—Crucial Players Organizing the Landscape of the Neuronal Nucleus
title_full_unstemmed Long Noncoding RNAs—Crucial Players Organizing the Landscape of the Neuronal Nucleus
title_short Long Noncoding RNAs—Crucial Players Organizing the Landscape of the Neuronal Nucleus
title_sort long noncoding rnas—crucial players organizing the landscape of the neuronal nucleus
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037058/
https://www.ncbi.nlm.nih.gov/pubmed/33801737
http://dx.doi.org/10.3390/ijms22073478
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