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Long Noncoding RNAs—Crucial Players Organizing the Landscape of the Neuronal Nucleus
The ability to regulate chromatin organization is particularly important in neurons, which dynamically respond to external stimuli. Accumulating evidence shows that lncRNAs play important architectural roles in organizing different nuclear domains like inactive chromosome X, splicing speckles, paras...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037058/ https://www.ncbi.nlm.nih.gov/pubmed/33801737 http://dx.doi.org/10.3390/ijms22073478 |
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author | Sas-Nowosielska, Hanna Magalska, Adriana |
author_facet | Sas-Nowosielska, Hanna Magalska, Adriana |
author_sort | Sas-Nowosielska, Hanna |
collection | PubMed |
description | The ability to regulate chromatin organization is particularly important in neurons, which dynamically respond to external stimuli. Accumulating evidence shows that lncRNAs play important architectural roles in organizing different nuclear domains like inactive chromosome X, splicing speckles, paraspeckles, and Gomafu nuclear bodies. LncRNAs are abundantly expressed in the nervous system where they may play important roles in compartmentalization of the cell nucleus. In this review we will describe the architectural role of lncRNAs in the nuclei of neuronal cells. |
format | Online Article Text |
id | pubmed-8037058 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-80370582021-04-12 Long Noncoding RNAs—Crucial Players Organizing the Landscape of the Neuronal Nucleus Sas-Nowosielska, Hanna Magalska, Adriana Int J Mol Sci Review The ability to regulate chromatin organization is particularly important in neurons, which dynamically respond to external stimuli. Accumulating evidence shows that lncRNAs play important architectural roles in organizing different nuclear domains like inactive chromosome X, splicing speckles, paraspeckles, and Gomafu nuclear bodies. LncRNAs are abundantly expressed in the nervous system where they may play important roles in compartmentalization of the cell nucleus. In this review we will describe the architectural role of lncRNAs in the nuclei of neuronal cells. MDPI 2021-03-27 /pmc/articles/PMC8037058/ /pubmed/33801737 http://dx.doi.org/10.3390/ijms22073478 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ). |
spellingShingle | Review Sas-Nowosielska, Hanna Magalska, Adriana Long Noncoding RNAs—Crucial Players Organizing the Landscape of the Neuronal Nucleus |
title | Long Noncoding RNAs—Crucial Players Organizing the Landscape of the Neuronal Nucleus |
title_full | Long Noncoding RNAs—Crucial Players Organizing the Landscape of the Neuronal Nucleus |
title_fullStr | Long Noncoding RNAs—Crucial Players Organizing the Landscape of the Neuronal Nucleus |
title_full_unstemmed | Long Noncoding RNAs—Crucial Players Organizing the Landscape of the Neuronal Nucleus |
title_short | Long Noncoding RNAs—Crucial Players Organizing the Landscape of the Neuronal Nucleus |
title_sort | long noncoding rnas—crucial players organizing the landscape of the neuronal nucleus |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037058/ https://www.ncbi.nlm.nih.gov/pubmed/33801737 http://dx.doi.org/10.3390/ijms22073478 |
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