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Molecular Mechanism of Cannabinoids in Cancer Progression
Cannabinoids are a family of heterogeneous compounds that mostly interact with receptors eliciting several physiological effects both in the central and peripheral nervous systems and in peripheral organs. They exert anticancer action by modulating signaling pathways involved in cancer progression;...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037087/ https://www.ncbi.nlm.nih.gov/pubmed/33916164 http://dx.doi.org/10.3390/ijms22073680 |
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author | Pagano, Cristina Navarra, Giovanna Coppola, Laura Bifulco, Maurizio Laezza, Chiara |
author_facet | Pagano, Cristina Navarra, Giovanna Coppola, Laura Bifulco, Maurizio Laezza, Chiara |
author_sort | Pagano, Cristina |
collection | PubMed |
description | Cannabinoids are a family of heterogeneous compounds that mostly interact with receptors eliciting several physiological effects both in the central and peripheral nervous systems and in peripheral organs. They exert anticancer action by modulating signaling pathways involved in cancer progression; furthermore, the effects induced by their use depend on both the type of tumor and their action on the components of the endocannabinoid system. This review will explore the mechanism of action of the cannabinoids in signaling pathways involved in cancer proliferation, neovascularisation, migration, invasion, metastasis, and tumor angiogenesis. |
format | Online Article Text |
id | pubmed-8037087 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-80370872021-04-12 Molecular Mechanism of Cannabinoids in Cancer Progression Pagano, Cristina Navarra, Giovanna Coppola, Laura Bifulco, Maurizio Laezza, Chiara Int J Mol Sci Review Cannabinoids are a family of heterogeneous compounds that mostly interact with receptors eliciting several physiological effects both in the central and peripheral nervous systems and in peripheral organs. They exert anticancer action by modulating signaling pathways involved in cancer progression; furthermore, the effects induced by their use depend on both the type of tumor and their action on the components of the endocannabinoid system. This review will explore the mechanism of action of the cannabinoids in signaling pathways involved in cancer proliferation, neovascularisation, migration, invasion, metastasis, and tumor angiogenesis. MDPI 2021-04-01 /pmc/articles/PMC8037087/ /pubmed/33916164 http://dx.doi.org/10.3390/ijms22073680 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Pagano, Cristina Navarra, Giovanna Coppola, Laura Bifulco, Maurizio Laezza, Chiara Molecular Mechanism of Cannabinoids in Cancer Progression |
title | Molecular Mechanism of Cannabinoids in Cancer Progression |
title_full | Molecular Mechanism of Cannabinoids in Cancer Progression |
title_fullStr | Molecular Mechanism of Cannabinoids in Cancer Progression |
title_full_unstemmed | Molecular Mechanism of Cannabinoids in Cancer Progression |
title_short | Molecular Mechanism of Cannabinoids in Cancer Progression |
title_sort | molecular mechanism of cannabinoids in cancer progression |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037087/ https://www.ncbi.nlm.nih.gov/pubmed/33916164 http://dx.doi.org/10.3390/ijms22073680 |
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