Cargando…
Polybrominated Diphenyl Ether Serum Concentrations and Depressive Symptomatology in Pregnant African American Women
(1) Polybrominated diphenyl ethers (PBDEs) were widely produced in the United States until 2004 but remain highly persistent in the environment. The potential for PBDEs to disrupt normal neuroendocrine pathways resulting in depression and other neurological symptoms is largely understudied. This stu...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037135/ https://www.ncbi.nlm.nih.gov/pubmed/33807211 http://dx.doi.org/10.3390/ijerph18073614 |
_version_ | 1783677072813588480 |
---|---|
author | Mutic, Abby D. Barr, Dana Boyd Hertzberg, Vicki S. Brennan, Patricia A. Dunlop, Anne L. McCauley, Linda A. |
author_facet | Mutic, Abby D. Barr, Dana Boyd Hertzberg, Vicki S. Brennan, Patricia A. Dunlop, Anne L. McCauley, Linda A. |
author_sort | Mutic, Abby D. |
collection | PubMed |
description | (1) Polybrominated diphenyl ethers (PBDEs) were widely produced in the United States until 2004 but remain highly persistent in the environment. The potential for PBDEs to disrupt normal neuroendocrine pathways resulting in depression and other neurological symptoms is largely understudied. This study examined whether PBDE exposure in pregnant women was associated with antenatal depressive symptomatology. (2) Data were collected from 193 African American pregnant women at 8–14 weeks gestation. Serum PBDEs and depressive symptoms were analyzed and a mixture effect was calculated. (3) Urban pregnant African American women in the Southeastern United States had a high risk of depression (27%) compared to the National average. Increased levels of PBDEs were found. BDE-47 and -99 exposures are significantly associated with depressive symptomatology in the pregnant cohort. The weighted body burden estimate of the PBDE mixture was associated with a higher risk of mild to moderate depression using an Edinburgh Depression Scale cutoff score of ≥10 (OR = 2.93; CI 1.18, 7.82). (4) Since antenatal depression may worsen in postpartum, reducing PBDE exposure may have significant clinical implications. |
format | Online Article Text |
id | pubmed-8037135 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-80371352021-04-12 Polybrominated Diphenyl Ether Serum Concentrations and Depressive Symptomatology in Pregnant African American Women Mutic, Abby D. Barr, Dana Boyd Hertzberg, Vicki S. Brennan, Patricia A. Dunlop, Anne L. McCauley, Linda A. Int J Environ Res Public Health Article (1) Polybrominated diphenyl ethers (PBDEs) were widely produced in the United States until 2004 but remain highly persistent in the environment. The potential for PBDEs to disrupt normal neuroendocrine pathways resulting in depression and other neurological symptoms is largely understudied. This study examined whether PBDE exposure in pregnant women was associated with antenatal depressive symptomatology. (2) Data were collected from 193 African American pregnant women at 8–14 weeks gestation. Serum PBDEs and depressive symptoms were analyzed and a mixture effect was calculated. (3) Urban pregnant African American women in the Southeastern United States had a high risk of depression (27%) compared to the National average. Increased levels of PBDEs were found. BDE-47 and -99 exposures are significantly associated with depressive symptomatology in the pregnant cohort. The weighted body burden estimate of the PBDE mixture was associated with a higher risk of mild to moderate depression using an Edinburgh Depression Scale cutoff score of ≥10 (OR = 2.93; CI 1.18, 7.82). (4) Since antenatal depression may worsen in postpartum, reducing PBDE exposure may have significant clinical implications. MDPI 2021-03-31 /pmc/articles/PMC8037135/ /pubmed/33807211 http://dx.doi.org/10.3390/ijerph18073614 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ). |
spellingShingle | Article Mutic, Abby D. Barr, Dana Boyd Hertzberg, Vicki S. Brennan, Patricia A. Dunlop, Anne L. McCauley, Linda A. Polybrominated Diphenyl Ether Serum Concentrations and Depressive Symptomatology in Pregnant African American Women |
title | Polybrominated Diphenyl Ether Serum Concentrations and Depressive Symptomatology in Pregnant African American Women |
title_full | Polybrominated Diphenyl Ether Serum Concentrations and Depressive Symptomatology in Pregnant African American Women |
title_fullStr | Polybrominated Diphenyl Ether Serum Concentrations and Depressive Symptomatology in Pregnant African American Women |
title_full_unstemmed | Polybrominated Diphenyl Ether Serum Concentrations and Depressive Symptomatology in Pregnant African American Women |
title_short | Polybrominated Diphenyl Ether Serum Concentrations and Depressive Symptomatology in Pregnant African American Women |
title_sort | polybrominated diphenyl ether serum concentrations and depressive symptomatology in pregnant african american women |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037135/ https://www.ncbi.nlm.nih.gov/pubmed/33807211 http://dx.doi.org/10.3390/ijerph18073614 |
work_keys_str_mv | AT muticabbyd polybrominateddiphenyletherserumconcentrationsanddepressivesymptomatologyinpregnantafricanamericanwomen AT barrdanaboyd polybrominateddiphenyletherserumconcentrationsanddepressivesymptomatologyinpregnantafricanamericanwomen AT hertzbergvickis polybrominateddiphenyletherserumconcentrationsanddepressivesymptomatologyinpregnantafricanamericanwomen AT brennanpatriciaa polybrominateddiphenyletherserumconcentrationsanddepressivesymptomatologyinpregnantafricanamericanwomen AT dunlopannel polybrominateddiphenyletherserumconcentrationsanddepressivesymptomatologyinpregnantafricanamericanwomen AT mccauleylindaa polybrominateddiphenyletherserumconcentrationsanddepressivesymptomatologyinpregnantafricanamericanwomen |