Design, Synthesis, Molecular Modeling and Antitumor Evaluation of Novel Indolyl-Pyrimidine Derivatives with EGFR Inhibitory Activity

Scaffolds hybridization is a well-known drug design strategy for antitumor agents. Herein, series of novel indolyl-pyrimidine hybrids were synthesized and evaluated in vitro and in vivo for their antitumor activity. The in vitro antiproliferative activity of all compounds was obtained against MCF-7,...

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Detalles Bibliográficos
Autores principales: Ahmed, Naglaa M., Youns, Mahmoud M., Soltan, Moustafa K., Said, Ahmed M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037142/
https://www.ncbi.nlm.nih.gov/pubmed/33805918
http://dx.doi.org/10.3390/molecules26071838

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037142/
https://www.ncbi.nlm.nih.gov/pubmed/33805918
http://dx.doi.org/10.3390/molecules26071838

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