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Prevalence of COVID-19 Vaccine Side Effects among Healthcare Workers in the Czech Republic

Background: COVID-19 vaccine side effects have a fundamental role in public confidence in the vaccine and its uptake process. Thus far, the evidence on vaccine safety has exclusively been obtained from the manufacturer-sponsored studies; therefore, this study was designed to provide independent evid...

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Autores principales: Riad, Abanoub, Pokorná, Andrea, Attia, Sameh, Klugarová, Jitka, Koščík, Michal, Klugar, Miloslav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037149/
https://www.ncbi.nlm.nih.gov/pubmed/33916020
http://dx.doi.org/10.3390/jcm10071428
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author Riad, Abanoub
Pokorná, Andrea
Attia, Sameh
Klugarová, Jitka
Koščík, Michal
Klugar, Miloslav
author_facet Riad, Abanoub
Pokorná, Andrea
Attia, Sameh
Klugarová, Jitka
Koščík, Michal
Klugar, Miloslav
author_sort Riad, Abanoub
collection PubMed
description Background: COVID-19 vaccine side effects have a fundamental role in public confidence in the vaccine and its uptake process. Thus far, the evidence on vaccine safety has exclusively been obtained from the manufacturer-sponsored studies; therefore, this study was designed to provide independent evidence on Pfizer–BioNTech COVID-19 vaccine side effects. Methods: A cross-sectional survey-based study was carried out between January and February 2021 to collect data on the side effects following the COVID-19 vaccine among healthcare workers in the Czech Republic. The study used a validated questionnaire with twenty-eight multiple-choice items covering the participants’ demographic data, medical anamneses, COVID-19-related anamneses, general, oral, and skin-related side effects. Results: Injection site pain (89.8%), fatigue (62.2%), headache (45.6%), muscle pain (37.1%), and chills (33.9%) were the most commonly reported side effects. All the general side effects were more prevalent among the ≤43-year-old group, and their duration was mainly one day (45.1%) or three days (35.8%) following the vaccine. Antihistamines were the most common drugs associated with side effects, thus requiring further investigation. The people with two doses were generally associated with a higher frequency of side effects. Conclusions: The distribution of side effects among Czech healthcare workers was highly consistent with the manufacturer’s data, especially in terms of their association with the younger age group and the second dose. The overall prevalence of some local and systemic side effects was higher than the manufacturer’s report. Further independent studies on vaccine safety are strongly required to strengthen public confidence in the vaccine.
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spelling pubmed-80371492021-04-12 Prevalence of COVID-19 Vaccine Side Effects among Healthcare Workers in the Czech Republic Riad, Abanoub Pokorná, Andrea Attia, Sameh Klugarová, Jitka Koščík, Michal Klugar, Miloslav J Clin Med Article Background: COVID-19 vaccine side effects have a fundamental role in public confidence in the vaccine and its uptake process. Thus far, the evidence on vaccine safety has exclusively been obtained from the manufacturer-sponsored studies; therefore, this study was designed to provide independent evidence on Pfizer–BioNTech COVID-19 vaccine side effects. Methods: A cross-sectional survey-based study was carried out between January and February 2021 to collect data on the side effects following the COVID-19 vaccine among healthcare workers in the Czech Republic. The study used a validated questionnaire with twenty-eight multiple-choice items covering the participants’ demographic data, medical anamneses, COVID-19-related anamneses, general, oral, and skin-related side effects. Results: Injection site pain (89.8%), fatigue (62.2%), headache (45.6%), muscle pain (37.1%), and chills (33.9%) were the most commonly reported side effects. All the general side effects were more prevalent among the ≤43-year-old group, and their duration was mainly one day (45.1%) or three days (35.8%) following the vaccine. Antihistamines were the most common drugs associated with side effects, thus requiring further investigation. The people with two doses were generally associated with a higher frequency of side effects. Conclusions: The distribution of side effects among Czech healthcare workers was highly consistent with the manufacturer’s data, especially in terms of their association with the younger age group and the second dose. The overall prevalence of some local and systemic side effects was higher than the manufacturer’s report. Further independent studies on vaccine safety are strongly required to strengthen public confidence in the vaccine. MDPI 2021-04-01 /pmc/articles/PMC8037149/ /pubmed/33916020 http://dx.doi.org/10.3390/jcm10071428 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Riad, Abanoub
Pokorná, Andrea
Attia, Sameh
Klugarová, Jitka
Koščík, Michal
Klugar, Miloslav
Prevalence of COVID-19 Vaccine Side Effects among Healthcare Workers in the Czech Republic
title Prevalence of COVID-19 Vaccine Side Effects among Healthcare Workers in the Czech Republic
title_full Prevalence of COVID-19 Vaccine Side Effects among Healthcare Workers in the Czech Republic
title_fullStr Prevalence of COVID-19 Vaccine Side Effects among Healthcare Workers in the Czech Republic
title_full_unstemmed Prevalence of COVID-19 Vaccine Side Effects among Healthcare Workers in the Czech Republic
title_short Prevalence of COVID-19 Vaccine Side Effects among Healthcare Workers in the Czech Republic
title_sort prevalence of covid-19 vaccine side effects among healthcare workers in the czech republic
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037149/
https://www.ncbi.nlm.nih.gov/pubmed/33916020
http://dx.doi.org/10.3390/jcm10071428
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