Cargando…

Effects of the Anti-Tumorigenic Agent AT101 on Human Glioblastoma Cells in the Microenvironmental Glioma Stem Cell Niche

Glioblastoma (GBM) is a barely treatable disease due to its profound chemoresistance. A distinct inter- and intratumoral heterogeneity reflected by specialized microenvironmental niches and different tumor cell subpopulations allows GBMs to evade therapy regimens. Thus, there is an urgent need to de...

Descripción completa

Detalles Bibliográficos
Autores principales:	Caylioglu, Deniz, Meyer, Rieke Johanna, Hellmold, Dana, Kubelt, Carolin, Synowitz, Michael, Held-Feindt, Janka
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037174/ https://www.ncbi.nlm.nih.gov/pubmed/33808494 http://dx.doi.org/10.3390/ijms22073606

Ejemplares similares

Insights into Gene Regulation under Temozolomide-Promoted Cellular Dormancy and Its Connection to Stemness in Human Glioblastoma
por: Kubelt, Carolin, et al.
Publicado: (2023)

Sequential Treatment with Temozolomide Plus Naturally Derived AT101 as an Alternative Therapeutic Strategy: Insights into Chemoresistance Mechanisms of Surviving Glioblastoma Cells
por: Hellmold, Dana, et al.
Publicado: (2023)

Establishment of a Rodent Glioblastoma Partial Resection Model for Chemotherapy by Local Drug Carriers—Sharing Experience
por: Kubelt, Carolin, et al.
Publicado: (2023)

Entry and exit of chemotherapeutically-promoted cellular dormancy in glioblastoma cells is differentially affected by the chemokines CXCL12, CXCL16, and CX3CL1
por: Adamski, Vivian, et al.
Publicado: (2020)

Fabrication and Modelling of a Reservoir-Based Drug Delivery System for Customizable Release
por: Hauck, Margarethe, et al.
Publicado: (2022)

Dormant glioblastoma cells acquire stem cell characteristics and are differentially affected by Temozolomide and AT101 treatment
por: Adamski, Vivian, et al.
Publicado: (2017)

Influence of Simulated Deep Brain Stimulation on the Expression of Inflammatory Mediators by Human Central Nervous System Cells In Vitro
por: Kubelt, Carolin, et al.
Publicado: (2021)

AT101-Loaded Cubosomes as an Alternative for Improved Glioblastoma Therapy
por: Flak, Dorota K, et al.
Publicado: (2020)

Intratumoral Distribution of Lactate and the Monocarboxylate Transporters 1 and 4 in Human Glioblastoma Multiforme and Their Relationships to Tumor Progression-Associated Markers
por: Kubelt, Carolin, et al.
Publicado: (2020)

Contribution of the Microenvironmental Niche to Glioblastoma Heterogeneity
por: Ho, Ivy A. W., et al.
Publicado: (2017)

Isolation and Characterization of Fast-Migrating Human Glioma Cells in the Progression of Malignant Gliomas
por: Adamski, Vivian, et al.
Publicado: (2017)

Tumor cell plasticity, heterogeneity, and resistance in crucial microenvironmental niches in glioma
por: Jung, Erik, et al.
Publicado: (2021)

Modeling treatment-dependent glioma growth including a dormant tumor cell subpopulation
por: Böttcher, Marvin A., et al.
Publicado: (2018)

Evaluation of a Brown Seaweed Extract from Dictyosiphon foeniculaceus as a Potential Therapeutic Agent for the Treatment of Glioblastoma and Uveal Melanoma
por: Dörschmann, Philipp, et al.
Publicado: (2020)

Dormancy and NKG2D system in brain metastases: Analysis of immunogenicity
por: Flüh, Charlotte, et al.
Publicado: (2020)

Thyroid Cancer Stem-Like Cells: From Microenvironmental Niches to Therapeutic Strategies
por: Grassi, Elisa Stellaria, et al.
Publicado: (2021)

Histological Characterization of the Tumorigenic “Peri-Necrotic Niche” Harboring Quiescent Stem-Like Tumor Cells in Glioblastoma
por: Ishii, Aya, et al.
Publicado: (2016)

Implantable pre-metastatic niches for the study of the microenvironmental regulation of disseminated human tumour cells
por: Carpenter, Ryan A., et al.
Publicado: (2018)

Molecular and Microenvironmental Determinants of Glioma Stem-Like Cell Survival and Invasion
por: Roos, Alison, et al.
Publicado: (2017)

The Chemokine Receptor CXCR6 Evokes Reverse Signaling via the Transmembrane Chemokine CXCL16
por: Adamski, Vivian, et al.
Publicado: (2017)

Regulation of Osteosclerosis by Inoculated Cd133(+) PC3 Cells in Bone‐marrow Microenvironmental Niches
por: Kim, Donghwi, et al.
Publicado: (2019)

CCR2 of Tumor Microenvironmental Cells Is a Relevant Modulator of Glioma Biology
por: Felsenstein, Matthäus, et al.
Publicado: (2020)

“Inverse signaling” of the transmembrane chemokine CXCL16 contributes to proliferative and anti-apoptotic effects in cultured human meningioma cells
por: Hattermann, Kirsten, et al.
Publicado: (2016)

The Molecular and Microenvironmental Landscape of Glioblastomas: Implications for the Novel Treatment Choices
por: Di Cintio, Federica, et al.
Publicado: (2020)

Sprouty2 enhances the tumorigenic potential of glioblastoma cells
por: Park, Jong-Whi, et al.
Publicado: (2018)

Microenvironmental niche divergence shapes BRCA1-dysregulated ovarian cancer morphological plasticity
por: Heindl, Andreas, et al.
Publicado: (2018)

The long and winding road: homeostatic and disordered haematopoietic microenvironmental niches: a narrative review
por: Watt, Suzanne M.
Publicado: (2022)

The Three-Layer Concentric Model of Glioblastoma: Cancer Stem Cells, Microenvironmental Regulation, and Therapeutic Implications
por: Persano, Luca, et al.
Publicado: (2011)

Microenvironmental Modulation of Decorin and Lumican in Temozolomide-Resistant Glioblastoma and Neuroblastoma Cancer Stem-Like Cells
por: Farace, Cristiano, et al.
Publicado: (2015)

Microenvironmental Rigidity of 3D Scaffolds and Influence on Glioblastoma Cells: A Biomaterial Design Perspective
por: Palamà, Ilaria Elena, et al.
Publicado: (2018)

Microenvironmental Stiffness Enhances Glioma Cell Proliferation by Stimulating Epidermal Growth Factor Receptor Signaling
por: Umesh, Vaibhavi, et al.
Publicado: (2014)

Microglia/Astrocytes–Glioblastoma Crosstalk: Crucial Molecular Mechanisms and Microenvironmental Factors
por: Matias, Diana, et al.
Publicado: (2018)

Coordination of signalling networks and tumorigenic properties by ABL in glioblastoma cells
por: Lamballe, Fabienne, et al.
Publicado: (2016)

Suppressing Dazl modulates tumorigenicity and stemness in human glioblastoma cells
por: Zhang, Fengyu, et al.
Publicado: (2020)

Microenvironmental regulation of T-cells in pulmonary hypertension
por: Plecitá-Hlavatá, Lydie, et al.
Publicado: (2023)

Snail depletes the tumorigenic potential of glioblastoma
por: Savary, K, et al.
Publicado: (2013)

Targeting PTPRZ inhibits stem cell-like properties and tumorigenicity in glioblastoma cells
por: Fujikawa, Akihiro, et al.
Publicado: (2017)

Thrombospondin-1 Is Downregulated by Anoxia and Suppresses Tumorigenicity of Human Glioblastoma Cells
por: Tenan, Mirna, et al.
Publicado: (2000)

REST Controls Self-Renewal and Tumorigenic Competence of Human Glioblastoma Cells
por: Conti, Luciano, et al.
Publicado: (2012)

Downregulation of ADAMTS3 Suppresses Stemness and Tumorigenicity in Glioma Stem Cell
por: Kim, Hyun‐Jin, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_6k134mj70lf2oegu6ab0fdei97