The Post-Translational Regulation of Epithelial–Mesenchymal Transition-Inducing Transcription Factors in Cancer Metastasis

Epithelial–mesenchymal transition (EMT) is generally observed in normal embryogenesis and wound healing. However, this process can occur in cancer cells and lead to metastasis. The contribution of EMT in both development and pathology has been studied widely. This transition requires the up- and dow...

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Detalles Bibliográficos
Autores principales: Kang, Eunjeong, Seo, Jihye, Yoon, Haelim, Cho, Sayeon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037257/
https://www.ncbi.nlm.nih.gov/pubmed/33808323
http://dx.doi.org/10.3390/ijms22073591
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author Kang, Eunjeong
Seo, Jihye
Yoon, Haelim
Cho, Sayeon
author_facet Kang, Eunjeong
Seo, Jihye
Yoon, Haelim
Cho, Sayeon
author_sort Kang, Eunjeong
collection PubMed
description Epithelial–mesenchymal transition (EMT) is generally observed in normal embryogenesis and wound healing. However, this process can occur in cancer cells and lead to metastasis. The contribution of EMT in both development and pathology has been studied widely. This transition requires the up- and down-regulation of specific proteins, both of which are regulated by EMT-inducing transcription factors (EMT-TFs), mainly represented by the families of Snail, Twist, and ZEB proteins. This review highlights the roles of key EMT-TFs and their post-translational regulation in cancer metastasis.
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spelling pubmed-80372572021-04-12 The Post-Translational Regulation of Epithelial–Mesenchymal Transition-Inducing Transcription Factors in Cancer Metastasis Kang, Eunjeong Seo, Jihye Yoon, Haelim Cho, Sayeon Int J Mol Sci Review Epithelial–mesenchymal transition (EMT) is generally observed in normal embryogenesis and wound healing. However, this process can occur in cancer cells and lead to metastasis. The contribution of EMT in both development and pathology has been studied widely. This transition requires the up- and down-regulation of specific proteins, both of which are regulated by EMT-inducing transcription factors (EMT-TFs), mainly represented by the families of Snail, Twist, and ZEB proteins. This review highlights the roles of key EMT-TFs and their post-translational regulation in cancer metastasis. MDPI 2021-03-30 /pmc/articles/PMC8037257/ /pubmed/33808323 http://dx.doi.org/10.3390/ijms22073591 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kang, Eunjeong
Seo, Jihye
Yoon, Haelim
Cho, Sayeon
The Post-Translational Regulation of Epithelial–Mesenchymal Transition-Inducing Transcription Factors in Cancer Metastasis
title The Post-Translational Regulation of Epithelial–Mesenchymal Transition-Inducing Transcription Factors in Cancer Metastasis
title_full The Post-Translational Regulation of Epithelial–Mesenchymal Transition-Inducing Transcription Factors in Cancer Metastasis
title_fullStr The Post-Translational Regulation of Epithelial–Mesenchymal Transition-Inducing Transcription Factors in Cancer Metastasis
title_full_unstemmed The Post-Translational Regulation of Epithelial–Mesenchymal Transition-Inducing Transcription Factors in Cancer Metastasis
title_short The Post-Translational Regulation of Epithelial–Mesenchymal Transition-Inducing Transcription Factors in Cancer Metastasis
title_sort post-translational regulation of epithelial–mesenchymal transition-inducing transcription factors in cancer metastasis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037257/
https://www.ncbi.nlm.nih.gov/pubmed/33808323
http://dx.doi.org/10.3390/ijms22073591
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