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Correlation between Biomarkers of Pain in Saliva and PAINAD Scale in Elderly People with Cognitive Impairment and Inability to Communicate

The pain assessment in advanced dementia (PAINAD) appears to be a clinically useful tool. However, the salivary determination of tumor necrosis factor receptor type II (sTNF-RII) and secretory IgA (sIgA) as pain biomarkers is still incipient. The aim was to correlate the PAINAD score with sTNF-RII a...

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Autores principales: Cantón-Habas, Vanesa, Rich-Ruiz, Manuel, Moreno-Casbas, María Teresa, Ramírez-Expósito, María Jesús, Martínez-Martos, Jose Manuel, Carrera-González, María Del Pilar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037327/
https://www.ncbi.nlm.nih.gov/pubmed/33915996
http://dx.doi.org/10.3390/jcm10071424
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author Cantón-Habas, Vanesa
Rich-Ruiz, Manuel
Moreno-Casbas, María Teresa
Ramírez-Expósito, María Jesús
Martínez-Martos, Jose Manuel
Carrera-González, María Del Pilar
author_facet Cantón-Habas, Vanesa
Rich-Ruiz, Manuel
Moreno-Casbas, María Teresa
Ramírez-Expósito, María Jesús
Martínez-Martos, Jose Manuel
Carrera-González, María Del Pilar
author_sort Cantón-Habas, Vanesa
collection PubMed
description The pain assessment in advanced dementia (PAINAD) appears to be a clinically useful tool. However, the salivary determination of tumor necrosis factor receptor type II (sTNF-RII) and secretory IgA (sIgA) as pain biomarkers is still incipient. The aim was to correlate the PAINAD score with sTNF-RII and sIgA biomarker levels in the saliva of patients with advanced dementia. In this regard, a cross-sectional study was conducted. The sample consisted of 75 elderly patients with a clinical diagnosis of dementia and a global deterioration scale (GDS) score of 5 to 7. The PAINAD scale was determined by a previously trained professional and the collection of salivary samples was performed using the passive secretion method. Human sTNF-RII and sIgA using ELISA kits. The results showed a correlation between the PAINAD scale (numeric, binary, and recoded) and sTNF-RII and sIgA (p < 0.001). No association between the sociodemographic and clinical variables and the PAINAD scale was found (p > 0.05). Between 97.3% and 96.2% of patients with pain on the PAINAD scale also showed pain based on the sTNF-RII levels; in all of them, sIgA levels did not fit the logistic models. Therefore, the correlation highlights the usefulness of this scale and confirms the usefulness of sTNF-RII and sIgA as biomarkers of pain.
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spelling pubmed-80373272021-04-12 Correlation between Biomarkers of Pain in Saliva and PAINAD Scale in Elderly People with Cognitive Impairment and Inability to Communicate Cantón-Habas, Vanesa Rich-Ruiz, Manuel Moreno-Casbas, María Teresa Ramírez-Expósito, María Jesús Martínez-Martos, Jose Manuel Carrera-González, María Del Pilar J Clin Med Article The pain assessment in advanced dementia (PAINAD) appears to be a clinically useful tool. However, the salivary determination of tumor necrosis factor receptor type II (sTNF-RII) and secretory IgA (sIgA) as pain biomarkers is still incipient. The aim was to correlate the PAINAD score with sTNF-RII and sIgA biomarker levels in the saliva of patients with advanced dementia. In this regard, a cross-sectional study was conducted. The sample consisted of 75 elderly patients with a clinical diagnosis of dementia and a global deterioration scale (GDS) score of 5 to 7. The PAINAD scale was determined by a previously trained professional and the collection of salivary samples was performed using the passive secretion method. Human sTNF-RII and sIgA using ELISA kits. The results showed a correlation between the PAINAD scale (numeric, binary, and recoded) and sTNF-RII and sIgA (p < 0.001). No association between the sociodemographic and clinical variables and the PAINAD scale was found (p > 0.05). Between 97.3% and 96.2% of patients with pain on the PAINAD scale also showed pain based on the sTNF-RII levels; in all of them, sIgA levels did not fit the logistic models. Therefore, the correlation highlights the usefulness of this scale and confirms the usefulness of sTNF-RII and sIgA as biomarkers of pain. MDPI 2021-04-01 /pmc/articles/PMC8037327/ /pubmed/33915996 http://dx.doi.org/10.3390/jcm10071424 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cantón-Habas, Vanesa
Rich-Ruiz, Manuel
Moreno-Casbas, María Teresa
Ramírez-Expósito, María Jesús
Martínez-Martos, Jose Manuel
Carrera-González, María Del Pilar
Correlation between Biomarkers of Pain in Saliva and PAINAD Scale in Elderly People with Cognitive Impairment and Inability to Communicate
title Correlation between Biomarkers of Pain in Saliva and PAINAD Scale in Elderly People with Cognitive Impairment and Inability to Communicate
title_full Correlation between Biomarkers of Pain in Saliva and PAINAD Scale in Elderly People with Cognitive Impairment and Inability to Communicate
title_fullStr Correlation between Biomarkers of Pain in Saliva and PAINAD Scale in Elderly People with Cognitive Impairment and Inability to Communicate
title_full_unstemmed Correlation between Biomarkers of Pain in Saliva and PAINAD Scale in Elderly People with Cognitive Impairment and Inability to Communicate
title_short Correlation between Biomarkers of Pain in Saliva and PAINAD Scale in Elderly People with Cognitive Impairment and Inability to Communicate
title_sort correlation between biomarkers of pain in saliva and painad scale in elderly people with cognitive impairment and inability to communicate
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037327/
https://www.ncbi.nlm.nih.gov/pubmed/33915996
http://dx.doi.org/10.3390/jcm10071424
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