Cargando…

Cytotoxic Activity of LLO Y406A Is Targeted to the Plasma Membrane of Cancer Urothelial Cells

Identification of novel agents for bladder cancer treatment is highly desirable due to the high incidence of tumor recurrence and the risk of progression to muscle-invasive disease. The key feature of the cholesterol-dependent toxin listeriolysin O mutant (LLO Y406A) is its preferential activity at...

Descripción completa

Detalles Bibliográficos
Autores principales:	Resnik, Nataša, Tratnjek, Larisa, Kreft, Mateja Erdani, Kisovec, Matic, Aden, Saša, Bedina Zavec, Apolonija, Anderluh, Gregor, Podobnik, Marjetka, Veranič, Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037347/ https://www.ncbi.nlm.nih.gov/pubmed/33805017 http://dx.doi.org/10.3390/ijms22073305

Ejemplares similares

Design of Protein Logic Gate System Operating on Lipid Membranes
por: Omersa, Neža, et al.
Publicado: (2020)

Listeriolysin O Membrane Damaging Activity Involves Arc Formation and Lineaction -- Implication for Listeria monocytogenes Escape from Phagocytic Vacuole
por: Ruan, Yi, et al.
Publicado: (2016)

Stability of Erythrocyte-Derived Nanovesicles Assessed by Light Scattering and Electron Microscopy
por: Božič, Darja, et al.
Publicado: (2021)

Assessment of Small Cellular Particles from Four Different Natural Sources and Liposomes by Interferometric Light Microscopy
por: Romolo, Anna, et al.
Publicado: (2022)

Highly Selective Anti-Cancer Activity of Cholesterol-Interacting Agents Methyl-β-Cyclodextrin and Ostreolysin A/Pleurotolysin B Protein Complex on Urothelial Cancer Cells
por: Resnik, Nataša, et al.
Publicado: (2015)

Identification of Tomato Infecting Viruses That Co-Isolate with Nanovesicles Using a Combined Proteomics and Electron-Microscopic Approach
por: Mammadova, Ramila, et al.
Publicado: (2021)

Molecular, morphological and functional properties of tunnelling nanotubes between normal and cancer urothelial cells: New insights from the in vitro model mimicking the situation after surgical removal of the urothelial tumor
por: Resnik, Nataša, et al.
Publicado: (2022)

Attachment of Cancer Urothelial Cells to the Bladder Epithelium Occurs on Uroplakin-Negative Cells and Is Mediated by Desmosomal and Not by Classical Cadherins
por: Jerman, Urška Dragin, et al.
Publicado: (2021)

Helical organization of microtubules occurs in a minority of tunneling membrane nanotubes in normal and cancer urothelial cells
por: Resnik, Nataša, et al.
Publicado: (2018)

Interaction between Microalgae P. tricornutum and Bacteria Thalassospira sp. for Removal of Bisphenols from Conditioned Media
por: Škufca, David, et al.
Publicado: (2022)

A Novel Localization in Human Large Extracellular Vesicles for the EGF-CFC Founder Member CRIPTO and Its Biological and Therapeutic Implications
por: Mantile, Francesca, et al.
Publicado: (2022)

Selective targeting of lectins and their macropinocytosis in urothelial tumours: translation from in vitro to ex vivo
por: Resnik, Nataša, et al.
Publicado: (2023)

Human Amniotic Membrane Enriched with Urinary Bladder Fibroblasts Promote the Re-Epithelization of Urothelial Injury
por: Jerman, Urška Dragin, et al.
Publicado: (2020)

The Antibacterial Activity of Human Amniotic Membrane against Multidrug-Resistant Bacteria Associated with Urinary Tract Infections: New Insights from Normal and Cancerous Urothelial Models
por: Ramuta, Taja Železnik, et al.
Publicado: (2021)

In Vitro Ciliotoxicity and Cytotoxicity Testing of Repeated Chronic Exposure to Topical Nasal Formulations for Safety Studies
por: Tratnjek, Larisa, et al.
Publicado: (2021)

A Novel Strain of Porcine Adenovirus Detected in Urinary Bladder Urothelial Cell Culture
por: Jerman, Urška Dragin, et al.
Publicado: (2014)

Comprehensive transcriptome profiling of urothelial cells following TNFα stimulation in an in vitro interstitial cystitis/bladder pain syndrome model
por: Kuret, Tadeja, et al.
Publicado: (2022)

Freeze-Fracture Replica Immunolabelling Reveals Urothelial Plaques in Cultured Urothelial Cells
por: Kreft, Mateja Erdani, et al.
Publicado: (2012)

Inclusion bodies as potential vehicles for recombinant protein delivery into epithelial cells
por: Liovic, Mirjana, et al.
Publicado: (2012)

Standardization of esophageal adenocarcinoma in vitro model and its applicability for model drug testing
por: Tratnjek, Larisa, et al.
Publicado: (2021)

A Biomimetic Porcine Urothelial Model for Assessing Escherichia coli Pathogenicity
por: Predojević, Luka, et al.
Publicado: (2022)

Corrigendum: Plasticity of Listeriolysin O Pores and its Regulation by pH and Unique Histidine
por: Podobnik, Marjetka, et al.
Publicado: (2015)

Plasticity of Listeriolysin O Pores and its Regulation by pH and Unique Histidine
por: Podobnik, Marjetka, et al.
Publicado: (2015)

The Cells and Extracellular Matrix of Human Amniotic Membrane Hinder the Growth and Invasive Potential of Bladder Urothelial Cancer Cells
por: Ramuta, Taja Železnik, et al.
Publicado: (2020)

Engineering a pH responsive pore forming protein
por: Kisovec, Matic, et al.
Publicado: (2017)

Cannabidiol as a Promising Therapeutic Option in IC/BPS: In Vitro Evaluation of Its Protective Effects against Inflammation and Oxidative Stress
por: Kuret, Tadeja, et al.
Publicado: (2023)

Post - prandial rise of microvesicles in peripheral blood of healthy human donors
por: Šuštar, Vid, et al.
Publicado: (2011)

The Golgi complex: An organelle that determines urothelial cell biology in health and disease
por: Kreft, Mateja Erdani, et al.
Publicado: (2022)

Small Cellular Particles from European Spruce Needle Homogenate
por: Jeran, Marko, et al.
Publicado: (2023)

Establishing and functional characterization of an HEK-293 cell line expressing autofluorescently tagged β-actin (pEYFP-ACTIN) and the neurokinin type 1 receptor (NK1-R)
por: Hrovat, Alenka, et al.
Publicado: (2009)

Proposing Urothelial and Muscle In Vitro Cell Models as a Novel Approach for Assessment of Long-Term Toxicity of Nanoparticles
por: Skočaj, Matej, et al.
Publicado: (2020)

Inhibition of Pore-Forming Proteins
por: Omersa, Neža, et al.
Publicado: (2019)

Gold nanoparticles as physiological markers of urine internalization into urothelial cells in vivo
por: Hudoklin, Samo, et al.
Publicado: (2013)

Combined lectin- and immuno-histochemistry (CLIH) for applications in cell biology and cancer diagnosis: Analysis of human urothelial carcinomas
por: Zupančič, Daša, et al.
Publicado: (2020)

Detrimental Effect of Various Preparations of the Human Amniotic Membrane Homogenate on the 2D and 3D Bladder Cancer In vitro Models
por: Janev, Aleksandar, et al.
Publicado: (2021)

Intestinal Cell Barrier Function In Vitro Is Severely Compromised by Keratin 8 and 18 Mutations Identified in Patients with Inflammatory Bowel Disease
por: Zupancic, Tina, et al.
Publicado: (2014)

Uroplakin traffic through the Golgi apparatus induces its fragmentation: new insights from novel in vitro models
por: Višnjar, Tanja, et al.
Publicado: (2017)

Involvement of Potato (Solanum tuberosum L.) MKK6 in Response to Potato virus Y
por: Lazar, Ana, et al.
Publicado: (2014)

Nanoparticles isolated from blood: a reflection of vesiculability of blood cells during the isolation process
por: Šuštar, Vid, et al.
Publicado: (2011)

More than one way to bind to cholesterol: atypical variants of membrane-binding domain of perfringolysin O selected by ribosome display
por: Šakanović, Aleksandra, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_br82m5gaen148lt4jck46gda8e