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Fatty Liver Is Associated with Low N-Terminal Pro-B-Type Natriuretic Peptide in a Healthy Population

Fatty liver (FL), insulin resistance (IR) and obesity often coexist, but data on the independent impacts of these factors on N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels are scarce. We examined the impact of FL, IR and obesity on NT-proBNP levels using a large set of cross-sectional...

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Autores principales: Choi, Hyo-In, Lee, Mi Yeon, Oh, Byeong Kil, Lee, Seung Jae, Kang, Jeong Gyu, Lee, Sung Ho, Lee, Jong-Young, Kim, Byung Jin, Kim, Bum Soo, Kang, Jin Ho, Sung, Ki-Chul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037377/
https://www.ncbi.nlm.nih.gov/pubmed/33915723
http://dx.doi.org/10.3390/jcm10071402
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author Choi, Hyo-In
Lee, Mi Yeon
Oh, Byeong Kil
Lee, Seung Jae
Kang, Jeong Gyu
Lee, Sung Ho
Lee, Jong-Young
Kim, Byung Jin
Kim, Bum Soo
Kang, Jin Ho
Sung, Ki-Chul
author_facet Choi, Hyo-In
Lee, Mi Yeon
Oh, Byeong Kil
Lee, Seung Jae
Kang, Jeong Gyu
Lee, Sung Ho
Lee, Jong-Young
Kim, Byung Jin
Kim, Bum Soo
Kang, Jin Ho
Sung, Ki-Chul
author_sort Choi, Hyo-In
collection PubMed
description Fatty liver (FL), insulin resistance (IR) and obesity often coexist, but data on the independent impacts of these factors on N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels are scarce. We examined the impact of FL, IR and obesity on NT-proBNP levels using a large set of cross-sectional data. The associations of FL, IR and obesity with NT-proBNP were analyzed in 39,923 healthy adult participants. IR was estimated using a homeostasis model assessment-estimated insulin resistance (HOMA-IR) index. A multivariable regression model was conducted to identify associations between NT-proBNP and FL on abdominal ultrasound. FL, IR and obesity showed independent inverse associations with NT-proBNP after multiple adjustments for baseline characteristics. In a multivariable regression model adjusting for IR and obesity, FL was independently associated with lower levels of NT-proBNP (estimates, Exp(β) 0.864, 0.849–0.880). The combination of FL and IR was a powerful dual indicator, lowering NT-proBNP levels approximately 25% in the generally healthy study population. In conclusion, FL was independently associated with lower NT-proBNP levels. FL and a high HOMA-IR index are a powerful indicator combination for lower NT-proBNP levels. Further research is needed to elucidate the mechanism underlying the association between FL and NT-proBNP.
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spelling pubmed-80373772021-04-12 Fatty Liver Is Associated with Low N-Terminal Pro-B-Type Natriuretic Peptide in a Healthy Population Choi, Hyo-In Lee, Mi Yeon Oh, Byeong Kil Lee, Seung Jae Kang, Jeong Gyu Lee, Sung Ho Lee, Jong-Young Kim, Byung Jin Kim, Bum Soo Kang, Jin Ho Sung, Ki-Chul J Clin Med Article Fatty liver (FL), insulin resistance (IR) and obesity often coexist, but data on the independent impacts of these factors on N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels are scarce. We examined the impact of FL, IR and obesity on NT-proBNP levels using a large set of cross-sectional data. The associations of FL, IR and obesity with NT-proBNP were analyzed in 39,923 healthy adult participants. IR was estimated using a homeostasis model assessment-estimated insulin resistance (HOMA-IR) index. A multivariable regression model was conducted to identify associations between NT-proBNP and FL on abdominal ultrasound. FL, IR and obesity showed independent inverse associations with NT-proBNP after multiple adjustments for baseline characteristics. In a multivariable regression model adjusting for IR and obesity, FL was independently associated with lower levels of NT-proBNP (estimates, Exp(β) 0.864, 0.849–0.880). The combination of FL and IR was a powerful dual indicator, lowering NT-proBNP levels approximately 25% in the generally healthy study population. In conclusion, FL was independently associated with lower NT-proBNP levels. FL and a high HOMA-IR index are a powerful indicator combination for lower NT-proBNP levels. Further research is needed to elucidate the mechanism underlying the association between FL and NT-proBNP. MDPI 2021-04-01 /pmc/articles/PMC8037377/ /pubmed/33915723 http://dx.doi.org/10.3390/jcm10071402 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Choi, Hyo-In
Lee, Mi Yeon
Oh, Byeong Kil
Lee, Seung Jae
Kang, Jeong Gyu
Lee, Sung Ho
Lee, Jong-Young
Kim, Byung Jin
Kim, Bum Soo
Kang, Jin Ho
Sung, Ki-Chul
Fatty Liver Is Associated with Low N-Terminal Pro-B-Type Natriuretic Peptide in a Healthy Population
title Fatty Liver Is Associated with Low N-Terminal Pro-B-Type Natriuretic Peptide in a Healthy Population
title_full Fatty Liver Is Associated with Low N-Terminal Pro-B-Type Natriuretic Peptide in a Healthy Population
title_fullStr Fatty Liver Is Associated with Low N-Terminal Pro-B-Type Natriuretic Peptide in a Healthy Population
title_full_unstemmed Fatty Liver Is Associated with Low N-Terminal Pro-B-Type Natriuretic Peptide in a Healthy Population
title_short Fatty Liver Is Associated with Low N-Terminal Pro-B-Type Natriuretic Peptide in a Healthy Population
title_sort fatty liver is associated with low n-terminal pro-b-type natriuretic peptide in a healthy population
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037377/
https://www.ncbi.nlm.nih.gov/pubmed/33915723
http://dx.doi.org/10.3390/jcm10071402
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