Cargando…
Fatty Liver Is Associated with Low N-Terminal Pro-B-Type Natriuretic Peptide in a Healthy Population
Fatty liver (FL), insulin resistance (IR) and obesity often coexist, but data on the independent impacts of these factors on N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels are scarce. We examined the impact of FL, IR and obesity on NT-proBNP levels using a large set of cross-sectional...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037377/ https://www.ncbi.nlm.nih.gov/pubmed/33915723 http://dx.doi.org/10.3390/jcm10071402 |
_version_ | 1783677129379020800 |
---|---|
author | Choi, Hyo-In Lee, Mi Yeon Oh, Byeong Kil Lee, Seung Jae Kang, Jeong Gyu Lee, Sung Ho Lee, Jong-Young Kim, Byung Jin Kim, Bum Soo Kang, Jin Ho Sung, Ki-Chul |
author_facet | Choi, Hyo-In Lee, Mi Yeon Oh, Byeong Kil Lee, Seung Jae Kang, Jeong Gyu Lee, Sung Ho Lee, Jong-Young Kim, Byung Jin Kim, Bum Soo Kang, Jin Ho Sung, Ki-Chul |
author_sort | Choi, Hyo-In |
collection | PubMed |
description | Fatty liver (FL), insulin resistance (IR) and obesity often coexist, but data on the independent impacts of these factors on N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels are scarce. We examined the impact of FL, IR and obesity on NT-proBNP levels using a large set of cross-sectional data. The associations of FL, IR and obesity with NT-proBNP were analyzed in 39,923 healthy adult participants. IR was estimated using a homeostasis model assessment-estimated insulin resistance (HOMA-IR) index. A multivariable regression model was conducted to identify associations between NT-proBNP and FL on abdominal ultrasound. FL, IR and obesity showed independent inverse associations with NT-proBNP after multiple adjustments for baseline characteristics. In a multivariable regression model adjusting for IR and obesity, FL was independently associated with lower levels of NT-proBNP (estimates, Exp(β) 0.864, 0.849–0.880). The combination of FL and IR was a powerful dual indicator, lowering NT-proBNP levels approximately 25% in the generally healthy study population. In conclusion, FL was independently associated with lower NT-proBNP levels. FL and a high HOMA-IR index are a powerful indicator combination for lower NT-proBNP levels. Further research is needed to elucidate the mechanism underlying the association between FL and NT-proBNP. |
format | Online Article Text |
id | pubmed-8037377 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-80373772021-04-12 Fatty Liver Is Associated with Low N-Terminal Pro-B-Type Natriuretic Peptide in a Healthy Population Choi, Hyo-In Lee, Mi Yeon Oh, Byeong Kil Lee, Seung Jae Kang, Jeong Gyu Lee, Sung Ho Lee, Jong-Young Kim, Byung Jin Kim, Bum Soo Kang, Jin Ho Sung, Ki-Chul J Clin Med Article Fatty liver (FL), insulin resistance (IR) and obesity often coexist, but data on the independent impacts of these factors on N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels are scarce. We examined the impact of FL, IR and obesity on NT-proBNP levels using a large set of cross-sectional data. The associations of FL, IR and obesity with NT-proBNP were analyzed in 39,923 healthy adult participants. IR was estimated using a homeostasis model assessment-estimated insulin resistance (HOMA-IR) index. A multivariable regression model was conducted to identify associations between NT-proBNP and FL on abdominal ultrasound. FL, IR and obesity showed independent inverse associations with NT-proBNP after multiple adjustments for baseline characteristics. In a multivariable regression model adjusting for IR and obesity, FL was independently associated with lower levels of NT-proBNP (estimates, Exp(β) 0.864, 0.849–0.880). The combination of FL and IR was a powerful dual indicator, lowering NT-proBNP levels approximately 25% in the generally healthy study population. In conclusion, FL was independently associated with lower NT-proBNP levels. FL and a high HOMA-IR index are a powerful indicator combination for lower NT-proBNP levels. Further research is needed to elucidate the mechanism underlying the association between FL and NT-proBNP. MDPI 2021-04-01 /pmc/articles/PMC8037377/ /pubmed/33915723 http://dx.doi.org/10.3390/jcm10071402 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Choi, Hyo-In Lee, Mi Yeon Oh, Byeong Kil Lee, Seung Jae Kang, Jeong Gyu Lee, Sung Ho Lee, Jong-Young Kim, Byung Jin Kim, Bum Soo Kang, Jin Ho Sung, Ki-Chul Fatty Liver Is Associated with Low N-Terminal Pro-B-Type Natriuretic Peptide in a Healthy Population |
title | Fatty Liver Is Associated with Low N-Terminal Pro-B-Type Natriuretic Peptide in a Healthy Population |
title_full | Fatty Liver Is Associated with Low N-Terminal Pro-B-Type Natriuretic Peptide in a Healthy Population |
title_fullStr | Fatty Liver Is Associated with Low N-Terminal Pro-B-Type Natriuretic Peptide in a Healthy Population |
title_full_unstemmed | Fatty Liver Is Associated with Low N-Terminal Pro-B-Type Natriuretic Peptide in a Healthy Population |
title_short | Fatty Liver Is Associated with Low N-Terminal Pro-B-Type Natriuretic Peptide in a Healthy Population |
title_sort | fatty liver is associated with low n-terminal pro-b-type natriuretic peptide in a healthy population |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037377/ https://www.ncbi.nlm.nih.gov/pubmed/33915723 http://dx.doi.org/10.3390/jcm10071402 |
work_keys_str_mv | AT choihyoin fattyliverisassociatedwithlownterminalprobtypenatriureticpeptideinahealthypopulation AT leemiyeon fattyliverisassociatedwithlownterminalprobtypenatriureticpeptideinahealthypopulation AT ohbyeongkil fattyliverisassociatedwithlownterminalprobtypenatriureticpeptideinahealthypopulation AT leeseungjae fattyliverisassociatedwithlownterminalprobtypenatriureticpeptideinahealthypopulation AT kangjeonggyu fattyliverisassociatedwithlownterminalprobtypenatriureticpeptideinahealthypopulation AT leesungho fattyliverisassociatedwithlownterminalprobtypenatriureticpeptideinahealthypopulation AT leejongyoung fattyliverisassociatedwithlownterminalprobtypenatriureticpeptideinahealthypopulation AT kimbyungjin fattyliverisassociatedwithlownterminalprobtypenatriureticpeptideinahealthypopulation AT kimbumsoo fattyliverisassociatedwithlownterminalprobtypenatriureticpeptideinahealthypopulation AT kangjinho fattyliverisassociatedwithlownterminalprobtypenatriureticpeptideinahealthypopulation AT sungkichul fattyliverisassociatedwithlownterminalprobtypenatriureticpeptideinahealthypopulation |