Design and In Vitro Evaluation of Splice-Switching Oligonucleotides Bearing Locked Nucleic Acids, Amido-Bridged Nucleic Acids, and Guanidine-Bridged Nucleic Acids

Our group previously developed a series of bridged nucleic acids (BNAs), including locked nucleic acids (LNAs), amido-bridged nucleic acids (AmNAs), and guanidine-bridged nucleic acids (GuNAs), to impart specific characteristics to oligonucleotides such as high-affinity binding and enhanced enzymati...

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Detalles Bibliográficos
Autores principales: Shimo, Takenori, Nakatsuji, Yusuke, Tachibana, Keisuke, Obika, Satoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037388/
https://www.ncbi.nlm.nih.gov/pubmed/33805378
http://dx.doi.org/10.3390/ijms22073526

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037388/
https://www.ncbi.nlm.nih.gov/pubmed/33805378
http://dx.doi.org/10.3390/ijms22073526

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