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The Role of B Cells in PE Pathophysiology: A Potential Target for Perinatal Cell-Based Therapy?

The pathophysiology of preeclampsia (PE) is poorly understood; however, there is a large body of evidence that suggests a role of immune cells in the development of PE. Amongst these, B cells are a dominant element in the pathogenesis of PE, and they have been shown to play an important role in vari...

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Autores principales: Magatti, Marta, Masserdotti, Alice, Cargnoni, Anna, Papait, Andrea, Stefani, Francesca Romana, Silini, Antonietta Rosa, Parolini, Ornella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037408/
https://www.ncbi.nlm.nih.gov/pubmed/33810280
http://dx.doi.org/10.3390/ijms22073405
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author Magatti, Marta
Masserdotti, Alice
Cargnoni, Anna
Papait, Andrea
Stefani, Francesca Romana
Silini, Antonietta Rosa
Parolini, Ornella
author_facet Magatti, Marta
Masserdotti, Alice
Cargnoni, Anna
Papait, Andrea
Stefani, Francesca Romana
Silini, Antonietta Rosa
Parolini, Ornella
author_sort Magatti, Marta
collection PubMed
description The pathophysiology of preeclampsia (PE) is poorly understood; however, there is a large body of evidence that suggests a role of immune cells in the development of PE. Amongst these, B cells are a dominant element in the pathogenesis of PE, and they have been shown to play an important role in various immune-mediated diseases, both as pro-inflammatory and regulatory cells. Perinatal cells are defined as cells from birth-associated tissues isolated from term placentas and fetal annexes and more specifically from the amniotic membrane, chorionic membrane, chorionic villi, umbilical cord (including Wharton’s jelly), the basal plate, and the amniotic fluid. They have drawn particular attention in recent years due to their ability to modulate several aspects of immunity, making them promising candidates for the prevention and treatment of various immune-mediated diseases. In this review we describe main findings regarding the multifaceted in vitro and in vivo immunomodulatory properties of perinatal cells, with a focus on B lymphocytes. Indeed, we discuss evidence on the ability of perinatal cells to inhibit B cell proliferation, impair B cell differentiation, and promote regulatory B cell formation. Therefore, the findings discussed herein unveil the possibility to modulate B cell activation and function by exploiting perinatal immunomodulatory properties, thus possibly representing a novel therapeutic strategy in PE.
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spelling pubmed-80374082021-04-12 The Role of B Cells in PE Pathophysiology: A Potential Target for Perinatal Cell-Based Therapy? Magatti, Marta Masserdotti, Alice Cargnoni, Anna Papait, Andrea Stefani, Francesca Romana Silini, Antonietta Rosa Parolini, Ornella Int J Mol Sci Review The pathophysiology of preeclampsia (PE) is poorly understood; however, there is a large body of evidence that suggests a role of immune cells in the development of PE. Amongst these, B cells are a dominant element in the pathogenesis of PE, and they have been shown to play an important role in various immune-mediated diseases, both as pro-inflammatory and regulatory cells. Perinatal cells are defined as cells from birth-associated tissues isolated from term placentas and fetal annexes and more specifically from the amniotic membrane, chorionic membrane, chorionic villi, umbilical cord (including Wharton’s jelly), the basal plate, and the amniotic fluid. They have drawn particular attention in recent years due to their ability to modulate several aspects of immunity, making them promising candidates for the prevention and treatment of various immune-mediated diseases. In this review we describe main findings regarding the multifaceted in vitro and in vivo immunomodulatory properties of perinatal cells, with a focus on B lymphocytes. Indeed, we discuss evidence on the ability of perinatal cells to inhibit B cell proliferation, impair B cell differentiation, and promote regulatory B cell formation. Therefore, the findings discussed herein unveil the possibility to modulate B cell activation and function by exploiting perinatal immunomodulatory properties, thus possibly representing a novel therapeutic strategy in PE. MDPI 2021-03-26 /pmc/articles/PMC8037408/ /pubmed/33810280 http://dx.doi.org/10.3390/ijms22073405 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Review
Magatti, Marta
Masserdotti, Alice
Cargnoni, Anna
Papait, Andrea
Stefani, Francesca Romana
Silini, Antonietta Rosa
Parolini, Ornella
The Role of B Cells in PE Pathophysiology: A Potential Target for Perinatal Cell-Based Therapy?
title The Role of B Cells in PE Pathophysiology: A Potential Target for Perinatal Cell-Based Therapy?
title_full The Role of B Cells in PE Pathophysiology: A Potential Target for Perinatal Cell-Based Therapy?
title_fullStr The Role of B Cells in PE Pathophysiology: A Potential Target for Perinatal Cell-Based Therapy?
title_full_unstemmed The Role of B Cells in PE Pathophysiology: A Potential Target for Perinatal Cell-Based Therapy?
title_short The Role of B Cells in PE Pathophysiology: A Potential Target for Perinatal Cell-Based Therapy?
title_sort role of b cells in pe pathophysiology: a potential target for perinatal cell-based therapy?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037408/
https://www.ncbi.nlm.nih.gov/pubmed/33810280
http://dx.doi.org/10.3390/ijms22073405
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