Current Knowledge and Perspectives of Pyrrolizidine Alkaloids in Pharmacological Applications: A Mini-Review

Pyrrolizidine alkaloids (PAs) are a widespread group of secondary metabolites in plants. PAs are notorious for their acute hepatotoxicity, genotoxicity and neurological damage to humans and animals. In recent decades, the application of PAs for beneficial biological activities to cure disease has dr...

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Detalles Bibliográficos
Autores principales: Wei, Xianqin, Ruan, Weibin, Vrieling, Klaas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037423/
https://www.ncbi.nlm.nih.gov/pubmed/33807368
http://dx.doi.org/10.3390/molecules26071970
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author Wei, Xianqin
Ruan, Weibin
Vrieling, Klaas
author_facet Wei, Xianqin
Ruan, Weibin
Vrieling, Klaas
author_sort Wei, Xianqin
collection PubMed
description Pyrrolizidine alkaloids (PAs) are a widespread group of secondary metabolites in plants. PAs are notorious for their acute hepatotoxicity, genotoxicity and neurological damage to humans and animals. In recent decades, the application of PAs for beneficial biological activities to cure disease has drawn greater attention. Here, we review the current knowledge regarding the pharmacological properties of PAs and discuss PAs as promising prototypes for the development of new drugs.
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spelling pubmed-80374232021-04-12 Current Knowledge and Perspectives of Pyrrolizidine Alkaloids in Pharmacological Applications: A Mini-Review Wei, Xianqin Ruan, Weibin Vrieling, Klaas Molecules Review Pyrrolizidine alkaloids (PAs) are a widespread group of secondary metabolites in plants. PAs are notorious for their acute hepatotoxicity, genotoxicity and neurological damage to humans and animals. In recent decades, the application of PAs for beneficial biological activities to cure disease has drawn greater attention. Here, we review the current knowledge regarding the pharmacological properties of PAs and discuss PAs as promising prototypes for the development of new drugs. MDPI 2021-03-31 /pmc/articles/PMC8037423/ /pubmed/33807368 http://dx.doi.org/10.3390/molecules26071970 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wei, Xianqin
Ruan, Weibin
Vrieling, Klaas
Current Knowledge and Perspectives of Pyrrolizidine Alkaloids in Pharmacological Applications: A Mini-Review
title Current Knowledge and Perspectives of Pyrrolizidine Alkaloids in Pharmacological Applications: A Mini-Review
title_full Current Knowledge and Perspectives of Pyrrolizidine Alkaloids in Pharmacological Applications: A Mini-Review
title_fullStr Current Knowledge and Perspectives of Pyrrolizidine Alkaloids in Pharmacological Applications: A Mini-Review
title_full_unstemmed Current Knowledge and Perspectives of Pyrrolizidine Alkaloids in Pharmacological Applications: A Mini-Review
title_short Current Knowledge and Perspectives of Pyrrolizidine Alkaloids in Pharmacological Applications: A Mini-Review
title_sort current knowledge and perspectives of pyrrolizidine alkaloids in pharmacological applications: a mini-review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037423/
https://www.ncbi.nlm.nih.gov/pubmed/33807368
http://dx.doi.org/10.3390/molecules26071970
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